{"id":"https://openalex.org/W2461581817","doi":null,"title":"Sex hormone involvement in the induction of experimental systemic lupus erythematosus by a pathogenic anti-DNA idiotype in naive mice.","display_name":"Sex hormone involvement in the induction of experimental systemic lupus erythematosus by a pathogenic anti-DNA idiotype in naive mice.","publication_year":1990,"publication_date":"1990-03-01","ids":{"openalex":"https://openalex.org/W2461581817","mag":"2461581817","pmid":"https://pubmed.ncbi.nlm.nih.gov/2332851"},"language":"en","primary_location":{"id":"pmid:2332851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2332851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102905134","display_name":"Miri Blank","orcid":"https://orcid.org/0000-0001-7248-6853","observed_orcids":["https://orcid.org/0000-0001-7248-6853"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"M Blank","raw_affiliation_strings":["Department of Medicine B, Sheba Medical Center, Tel-Hashomer, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine B, Sheba Medical Center, Tel-Hashomer, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085884949","display_name":"Shlomo Mendlovic","orcid":"https://orcid.org/0000-0002-0587-1169","observed_orcids":["https://orcid.org/0000-0002-0587-1169"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Mendlovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069442514","display_name":"Harald Fricke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Fricke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020352199","display_name":"Edna Mozes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Mozes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027316824","display_name":"Norman Talal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Talal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5074738902","display_name":"Yehuda Shoenfeld","orcid":"https://orcid.org/0000-0003-2802-4090","observed_orcids":["https://orcid.org/0000-0003-2802-4090","https://orcid.org/0000-0003-0185-9637"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Shoenfeld","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4542,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.87595908,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"17","issue":"3","first_page":"311","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-hormones","display_name":"sex hormones","score":0.824999988079071},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.953000009059906},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.6579999923706055},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.9959999918937683},{"id":"https://openalex.org/keywords/orchiectomy","display_name":"orchiectomy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.9240000247955322},{"id":"https://openalex.org/keywords/immune-complexes","display_name":"immune complexes","score":0.8029999732971191},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.3569999933242798},{"id":"https://openalex.org/keywords/lupus-flares","display_name":"lupus flares","score":0.4410000145435333},{"id":"https://openalex.org/keywords/naive-mice","display_name":"naive mice","score":0.5479999780654907},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7372155785560608},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.6935586929321289},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6864622235298157},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6133609414100647},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.6095268726348877},{"id":"https://openalex.org/C74505204","wikidata":"https://www.wikidata.org/wiki/Q1047644","display_name":"Idiotype","level":4,"score":0.5756995677947998},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5279159545898438},{"id":"https://openalex.org/C2780873365","wikidata":"https://www.wikidata.org/wiki/Q496812","display_name":"Leukopenia","level":3,"score":0.43049079179763794},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41199544072151184},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39174652099609375},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007130","descriptor_name":"Immunoglobulin Idiotypes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012739","descriptor_name":"Gonadal Steroid Hormones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2332851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2332851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},{"id":"mag:2461581817","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2332851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1567527922","https://openalex.org/W2934619971","https://openalex.org/W1985675546","https://openalex.org/W4413999936","https://openalex.org/W4290993396","https://openalex.org/W2027288222","https://openalex.org/W2340343168","https://openalex.org/W2007889187","https://openalex.org/W1984927734","https://openalex.org/W1965068360"],"abstract_inverted_index":{"The":[0,63],"effect":[1],"of":[2,8,28,45,65,73,91,94,122,160,166],"sex":[3,161],"hormones":[4,162],"on":[5,163],"the":[6,29,46,57,76,98,120,126,141,158,164],"induction":[7,165],"experimental":[9,167],"systemic":[10],"lupus":[11],"erythematosus":[12],"(SLE)":[13],"with":[14,39,107,172],"a":[15,42,137],"human":[16,142],"anti-DNA":[17,143],"(16/6":[18,145],"Id":[19,146],"+)":[20],"antibody,":[21],"was":[22,68],"studied.":[23],"We":[24],"found":[25],"that":[26],"injection":[27],"pathogenic":[30],"idiotype":[31],"to":[32,78,140,150,176],"BALB/c":[33,131],"females":[34,132],"and":[35,88,115,133],"orchiectomized":[36,134],"males":[37,135],"treated":[38,54,130],"estrogen":[40],"caused":[41],"rapid":[43],"outburst":[44],"disease":[47,58,67,169],"3":[48],"months":[49,60],"after":[50,61],"immunization,":[51],"while":[52],"nonestrogen":[53],"mice":[55,171],"developed":[56,136],"5":[59],"immunization.":[62],"flare":[64],"SLE":[66],"characterized":[69],"by":[70],"raised":[71],"levels":[72,104],"autoantibodies":[74],"in":[75,110,125,170],"sera":[77],"dsDNA,":[79],"histones,":[80],"cardiolipin,":[81],"Sm,":[82],"RNP,":[83],"SSA":[84],"(Ro),":[85],"SSB":[86],"(La)":[87],"an":[89,108],"emergence":[90],"high":[92],"titers":[93],"mouse":[95],"antibody":[96,103,144],"carrying":[97],"16/6":[99],"Id.":[100],"These":[101],"enhanced":[102],"were":[105],"associated":[106],"increase":[109],"erythrocyte":[111],"sedimentation":[112],"rate,":[113],"proteinuria":[114],"leukopenia.":[116],"Immunofluorescent":[117],"studies":[118],"confirmed":[119],"existence":[121],"immune":[123],"complexes":[124],"afflicted":[127],"kidneys.":[128],"Testosterone":[129],"classical":[138],"response":[139],"+),":[147],"but":[148],"failed":[149],"develop":[151],"fulminant":[152],"SLE-like":[153,168],"disease.":[154],"Our":[155],"data":[156],"demonstrate":[157],"importance":[159],"no":[173],"genetic":[174],"tendency":[175],"autoimmunity.":[177]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}