{"id":"https://openalex.org/W2460782880","doi":"https://doi.org/10.1097/gox.0000000000000734","title":"A Clinical Evaluation of Efficacy and Safety of Hyaluronan Sponge with Vitamin C Versus Placebo for Scar Reduction","display_name":"A Clinical Evaluation of Efficacy and Safety of Hyaluronan Sponge with Vitamin C Versus Placebo for Scar Reduction","publication_year":2016,"publication_date":"2016-07-01","ids":{"openalex":"https://openalex.org/W2460782880","doi":"https://doi.org/10.1097/gox.0000000000000734","mag":"2460782880","pmid":"https://pubmed.ncbi.nlm.nih.gov/27536471","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4977120"},"language":"en","primary_location":{"id":"doi:10.1097/gox.0000000000000734","doi":"https://doi.org/10.1097/gox.0000000000000734","is_oa":true,"landing_page_url":"https://doi.org/10.1097/gox.0000000000000734","pdf_url":null,"source":{"id":"https://openalex.org/S2754281505","display_name":"Plastic & Reconstructive Surgery Global Open","issn_l":"2169-7574","issn":["2169-7574"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery - Global Open","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/gox.0000000000000734","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008051027","display_name":"Bardia Amirlak","orcid":"https://orcid.org/0000-0002-2261-2011","observed_orcids":["https://orcid.org/0000-0002-2261-2011"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bardia Amirlak","raw_affiliation_strings":["Department of Plastic Surgery, University of Texas Southwestern School of Medicine, Dallas, Tex","Bardia Amirlak, MD, Department of Plastic Surgery, University of Texas Southwestern Medical Center, 1801 Inwood Rd, Dallas, TX 75390, [email\u00a0protected]","the Department of Plastic Surgery, University of Texas Southwestern School of Medicine, Dallas, Tex"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, University of Texas Southwestern School of Medicine, Dallas, Tex","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Bardia Amirlak, MD, Department of Plastic Surgery, University of Texas Southwestern Medical Center, 1801 Inwood Rd, Dallas, TX 75390, [email\u00a0protected]","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"the Department of Plastic Surgery, University of Texas Southwestern School of Medicine, Dallas, Tex","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053568611","display_name":"Monali Mahedia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monali Mahedia","raw_affiliation_strings":["Department of Plastic Surgery, University of Texas Southwestern School of Medicine, Dallas, Tex","the Department of Plastic Surgery, University of Texas Southwestern School of Medicine, Dallas, Tex"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, University of Texas Southwestern School of Medicine, Dallas, Tex","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"the Department of Plastic Surgery, University of Texas Southwestern School of Medicine, Dallas, Tex","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041424888","display_name":"Nilay D. Shah","orcid":"https://orcid.org/0000-0002-8597-3447","observed_orcids":["https://orcid.org/0000-0002-8597-3447"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nilay Shah","raw_affiliation_strings":["Department of Plastic Surgery, University of Texas Southwestern School of Medicine, Dallas, Tex","the Department of Plastic Surgery, University of Texas Southwestern School of Medicine, Dallas, Tex"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, University of Texas Southwestern School of Medicine, Dallas, Tex","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"the Department of Plastic Surgery, University of Texas Southwestern School of Medicine, Dallas, Tex","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008051027"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":2195,"currency":"USD","value_usd":2195},"apc_paid":{"value":2195,"currency":"USD","value_usd":2195},"fwci":1.6023,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.83087102,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":"7","first_page":"e792","last_page":"e792"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11322","display_name":"Facial Rejuvenation and Surgery Techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surgical-scar","display_name":"postoperative scarring","score":0.7120000123977661},{"id":"https://openalex.org/keywords/scar-reduction","display_name":"scar reduction","score":0.871999979019165},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.8999999761581421},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9570000171661377},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.753000020980835},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.48100000619888306},{"id":"https://openalex.org/keywords/patient-satisfaction","display_name":"patient satisfaction","score":0.9340000152587891}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.660475492477417},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.6273592710494995},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.5366712212562561},{"id":"https://openalex.org/C2780022331","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Vitamin C","level":2,"score":0.48403114080429077},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4550337791442871},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.44578707218170166},{"id":"https://openalex.org/C2778849931","wikidata":"https://www.wikidata.org/wiki/Q18960","display_name":"Sponge","level":2,"score":0.4181773066520691},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35518890619277954},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3260643482208252},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32511135935783386},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1537448763847351},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.15275079011917114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14838755130767822},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.12715557217597961},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0858289897441864},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1097/gox.0000000000000734","doi":"https://doi.org/10.1097/gox.0000000000000734","is_oa":true,"landing_page_url":"https://doi.org/10.1097/gox.0000000000000734","pdf_url":null,"source":{"id":"https://openalex.org/S2754281505","display_name":"Plastic & Reconstructive Surgery Global Open","issn_l":"2169-7574","issn":["2169-7574"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery - Global Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4977120","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4977120","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plast Reconstr Surg Glob Open","raw_type":"Text"},{"id":"pmid:27536471","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27536471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and reconstructive surgery. Global open","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/gox.0000000000000734","doi":"https://doi.org/10.1097/gox.0000000000000734","is_oa":true,"landing_page_url":"https://doi.org/10.1097/gox.0000000000000734","pdf_url":null,"source":{"id":"https://openalex.org/S2754281505","display_name":"Plastic & Reconstructive Surgery Global Open","issn_l":"2169-7574","issn":["2169-7574"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery - Global Open","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6499999761581421}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W48001675","https://openalex.org/W88708713","https://openalex.org/W216561038","https://openalex.org/W1582833462","https://openalex.org/W1875180226","https://openalex.org/W1972159087","https://openalex.org/W1980426365","https://openalex.org/W1980935556","https://openalex.org/W1982668498","https://openalex.org/W1987680851","https://openalex.org/W1988546919","https://openalex.org/W1989021197","https://openalex.org/W1989247281","https://openalex.org/W1989357445","https://openalex.org/W2007910143","https://openalex.org/W2010404817","https://openalex.org/W2025548094","https://openalex.org/W2047705770","https://openalex.org/W2053263072","https://openalex.org/W2056064788","https://openalex.org/W2066269968","https://openalex.org/W2070995184","https://openalex.org/W2071889889","https://openalex.org/W2078992526","https://openalex.org/W2083480349","https://openalex.org/W2083726368","https://openalex.org/W2085155766","https://openalex.org/W2097560755","https://openalex.org/W2100856679","https://openalex.org/W2123924347","https://openalex.org/W2138806959","https://openalex.org/W2144437151","https://openalex.org/W2146063109","https://openalex.org/W2147038478","https://openalex.org/W2158580742","https://openalex.org/W2158581886","https://openalex.org/W2173154466","https://openalex.org/W2321154548","https://openalex.org/W2331036897","https://openalex.org/W4235941377","https://openalex.org/W4237769345","https://openalex.org/W4243231451","https://openalex.org/W4301263623"],"related_works":["https://openalex.org/W2475120034","https://openalex.org/W2908597609","https://openalex.org/W4282918288","https://openalex.org/W3179446726","https://openalex.org/W108725695","https://openalex.org/W2898174299","https://openalex.org/W4400352089","https://openalex.org/W3119952025","https://openalex.org/W2007572254","https://openalex.org/W2740480724"],"abstract_inverted_index":{"BACKGROUND:":[0],"Scar":[1],"formation":[2],"after":[3,66,277],"injury":[4],"or":[5,14,86,110],"surgery":[6],"is":[7,256],"a":[8,130,169,244,274],"major":[9],"clinical":[10],"problem.":[11],"Individually,":[12],"hyaluronan,":[13],"hyaluronic":[15],"acid":[16],"(HA),":[17],"and":[18,37,61,64,125,150],"vitamin":[19,49,114,208,234,254],"C":[20,50,209,235,255],"have":[21,239],"been":[22],"shown":[23],"to":[24,51,107,238,258,282,288,290],"reduce":[25],"scarring":[26,65],"by":[27,76],"means":[28],"of":[29,39,48,56,121,165,171,181,295],"different":[30],"mechanisms.":[31],"The":[32,196,230,249,279],"authors":[33],"evaluated":[34],"the":[35,54,77,122,127,159,166,214,219,284,293,296],"efficacy":[36],"safety":[38],"an":[40,45],"HA":[41,111,205,231,250],"sponge":[42,112,206,232,251],"system":[43,252],"containing":[44],"active":[46],"derivative":[47],"determine":[52],"whether":[53],"use":[55,259,289],"this":[57],"product":[58,285],"promotes":[59],"healing":[60],"reduces":[62],"inflammation":[63],"surgery.":[67,278],"METHODS:":[68],"This":[69],"double-blind,":[70],"randomized,":[71],"prospective":[72],"study":[73],"was":[74,138,183,192,210,221,236,286],"approved":[75],"local":[78],"institutional":[79],"review":[80],"board.":[81],"Participants":[82,141],"who":[83],"had":[84],"unilateral":[85],"bilateral":[87],"surgical":[88],"scars":[89,103,128,203,215,262],"more":[90],"than":[91,96,213,264],"1":[92,151],"month":[93],"but":[94,218],"less":[95],"18":[97],"months":[98],"old":[99],"were":[100,104,142,156],"enrolled.":[101],"Surgical":[102],"randomly":[105],"assigned":[106],"receive":[108],"placebo":[109],"with":[113,207,233,253],"C.":[115],"Three":[116],"blinded":[117],"evaluators":[118],"reviewed":[119],"photographs":[120],"incision":[123],"lines":[124],"assessed":[126],"using":[129],"visual":[131,198],"analog":[132,199],"scale.":[133],"A":[134],"patient":[135,182,245,270],"satisfaction":[136,246,271],"survey":[137],"also":[139],"administered.":[140],"followed":[143],"up":[144],"at":[145],"4":[146,265],"weeks,":[147,149],"12":[148],"year.":[152],"RESULTS:":[153],"Twenty-three":[154],"patients":[155,162,173],"enrolled":[157],"in":[158,175,260,272,298],"study.":[160],"Six":[161],"dropped":[163],"out":[164],"study,":[167],"for":[168,202],"total":[170],"17":[172],"included":[174],"final":[176],"analysis.":[177],"Mean":[178,187],"(range)":[179,188],"age":[180],"43.5":[184],"(25-67)":[185],"years.":[186],"body":[189],"mass":[190],"index":[191],"27.4":[193],"(18-36.9)":[194],"kg/m(2).":[195],"mean":[197],"scale":[200],"score":[201],"receiving":[204,216],"slightly":[211],"lower":[212],"placebo,":[217],"difference":[220],"not":[222],"statistically":[223],"significant":[224,240],"(t":[225],"test;":[226],"P":[227],"=":[228],"0.9).":[229],"found":[237],"positive":[241],"findings":[242],"on":[243],"survey.":[247],"CONCLUSIONS:":[248],"safe":[257],"any":[261],"older":[263,299],"weeks.":[266],"It":[267],"has":[268],"high":[269],"achieving":[273],"better":[275],"scar":[276],"micro-roller":[280],"used":[281],"apply":[283],"easy":[287],"potentially":[291],"increase":[292],"spread":[294],"medication":[297],"scars.":[300]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-07-22T00:00:00"}
