{"id":"https://openalex.org/W2460367148","doi":"https://doi.org/10.1055/s-0038-1646039","title":"Characterization of Na+/H+ Exchange in Platelets","display_name":"Characterization of Na+/H+ Exchange in Platelets","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2460367148","doi":"https://doi.org/10.1055/s-0038-1646039","mag":"2460367148","pmid":"https://pubmed.ncbi.nlm.nih.gov/2832967"},"language":"en","primary_location":{"id":"doi:10.1055/s-0038-1646039","doi":"https://doi.org/10.1055/s-0038-1646039","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1646039","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111547601","display_name":"Avinoam A. Livne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Avinoam Livne","raw_affiliation_strings":["The Division of Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Division of Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063705444","display_name":"Sergio Grinstein","orcid":"https://orcid.org/0000-0002-0795-4160","observed_orcids":["https://orcid.org/0000-0002-0795-4160"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sergio Grinstein","raw_affiliation_strings":["The Division of Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Division of Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108381398","display_name":"Aser Rothstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Aser Rothstein","raw_affiliation_strings":["The Division of Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Division of Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801317318"],"apc_list":null,"apc_paid":null,"fwci":1.2761,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.78456358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"58","issue":"04","first_page":"971","last_page":"977"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/na-h-exchange","display_name":"Na+/H+ exchange","score":0.9179999828338623},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cytoplasmic-acidification","display_name":"cytoplasmic acidification","score":0.8569999933242798},{"id":"https://openalex.org/keywords/intracellular-ph-regulation","display_name":"intracellular pH regulation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/osmotic-swelling","display_name":"osmotic swelling","score":0.699999988079071},{"id":"https://openalex.org/keywords/propionate","display_name":"propionate","score":0.5360000133514404},{"id":"https://openalex.org/keywords/amiloride","display_name":"amiloride","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ouabain","display_name":"ouabain","score":0.656000018119812},{"id":"https://openalex.org/keywords/ion-selectivity","display_name":"ion selectivity","score":0.5649999976158142},{"id":"https://openalex.org/keywords/temperature-coefficient","display_name":"temperature coefficient","score":0.44999998807907104},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C2779608910","wikidata":"https://www.wikidata.org/wiki/Q419995","display_name":"Amiloride","level":3,"score":0.9044480919837952},{"id":"https://openalex.org/C114574056","wikidata":"https://www.wikidata.org/wiki/Q7553395","display_name":"Sodium\u2013hydrogen antiporter","level":3,"score":0.7462166547775269},{"id":"https://openalex.org/C2779133857","wikidata":"https://www.wikidata.org/wiki/Q285911","display_name":"Ouabain","level":3,"score":0.6786324977874756},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6705975532531738},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6604609489440918},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5675836801528931},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.5232530832290649},{"id":"https://openalex.org/C134897140","wikidata":"https://www.wikidata.org/wiki/Q6058355","display_name":"Intracellular pH","level":3,"score":0.5029026865959167},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.49912595748901367},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.44576114416122437},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3808927536010742},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3279646039009094},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.32195988297462463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14635953307151794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10440629720687866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10239756107330322},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000584","descriptor_name":"Amiloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007474","descriptor_name":"Ion Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010042","descriptor_name":"Ouabain","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0038-1646039","doi":"https://doi.org/10.1055/s-0038-1646039","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1646039","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmid:2832967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2832967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and haemostasis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2064568949","https://openalex.org/W2140551122","https://openalex.org/W2025282610","https://openalex.org/W2049601985","https://openalex.org/W2063707452","https://openalex.org/W1592379821","https://openalex.org/W2126335277","https://openalex.org/W2023906117","https://openalex.org/W2417005581","https://openalex.org/W2082522514"],"abstract_inverted_index":{"Acidification":[0],"of":[1,4,11,30,40,53,61,68,106,156],"the":[2,31,38,50,65,157,166],"cytoplasm":[3],"human":[5],"blood":[6],"platelets":[7,41],"leads":[8,56],"to":[9,57,74,82,85,90,117,154],"activation":[10,60],"Na+/H+":[12,62,78,167],"exchange.":[13],"As":[14],"a":[15,47,144,170],"result,":[16],"alkalinization":[17],"occurs":[18],"that":[19,87,165],"is":[20,80,96,115,130,163],"detectable":[21],"by":[22,37,137],"an":[23],"intracellular":[24],"fluorescent":[25],"pH":[26,174],"indicator.":[27],"The":[28,77],"activity":[29,129],"exchanger":[32,79,158,168],"can":[33],"also":[34],"be":[35,91],"measured":[36],"swelling":[39],"suspended":[42],"in":[43,132,151,159,172],"Na-propionate":[44],"medium":[45],"using":[46],"Coulter":[48],"Counter:":[49],"rapid":[51],"entry":[52,67],"propionic":[54,71],"acid":[55,72],"acidification":[58],"and":[59,70,84,100,126,141],"exchange":[63],"with":[64,102,135],"parallel":[66],"Na+":[69,99,114,125,136],"leading":[73],"osmotic":[75],"swelling.":[76],"sensitive":[81],"amiloride":[83],"derivatives":[86],"are":[88,150],"reported":[89],"more":[92],"specific":[93,97],"inhibitors;":[94],"it":[95,120,142],"for":[98,113],"Li+":[101],"no":[103],"measurable":[104],"transfer":[105],"K+,":[107],"Rb+":[108],"or":[109],"Cs+;":[110],"its":[111,128],"Km":[112],"75":[116],"90":[118],"mM;":[119],"displays":[121],"competitive":[122],"behavior":[123],"between":[124],"amiloride;":[127],"decreased":[131],"cells":[133],"loaded":[134],"prolonged":[138],"ouabain":[139],"treatment;":[140],"has":[143],"high":[145],"temperature":[146],"coefficient.":[147],"These":[148],"properties":[149],"general":[152],"similar":[153],"those":[155],"other":[160],"cells.":[161],"It":[162],"suggested":[164],"plays":[169],"role":[171],"platelet":[173],"regulation.":[175]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-07-22T00:00:00"}
