{"id":"https://openalex.org/W2460178047","doi":null,"title":"Effect of quinupristin/dalfopristin alone or in combination with vancomycin on the structure of Enterococcus faecium.","display_name":"Effect of quinupristin/dalfopristin alone or in combination with vancomycin on the structure of Enterococcus faecium.","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2460178047","mag":"2460178047","pmid":"https://pubmed.ncbi.nlm.nih.gov/9675547"},"language":"en","primary_location":{"id":"pmid:9675547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9675547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs under experimental and clinical research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072399662","display_name":"V\u00edctor Lorian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289079397","display_name":"Bronx-Lebanon Hospital Center","ror":"https://ror.org/0107ygt22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289079397"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V Lorian","raw_affiliation_strings":["Department of Epidemiology & Infection Control, Bronx-Lebanon Hospital Center, NY 10457, USA","Department of Epidemiology and Infection Control, Bronx-Lebanon Hospital Center, NY 10457, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology & Infection Control, Bronx-Lebanon Hospital Center, NY 10457, USA","institution_ids":["https://openalex.org/I1289079397"]},{"raw_affiliation_string":"Department of Epidemiology and Infection Control, Bronx-Lebanon Hospital Center, NY 10457, USA","institution_ids":["https://openalex.org/I1289079397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031883428","display_name":"Fleance Fernandes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Fernandes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.32880778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"24","issue":"2","first_page":"73","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.22349999845027924,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.03739999979734421,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enterococcus-faecium","display_name":"Enterococcus faecium","score":0.9549999833106995},{"id":"https://openalex.org/keywords/quinupristin-dalfopristin","display_name":"quinupristin/dalfopristin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/vancomycin-resistance","display_name":"vancomycin resistance","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.5820000171661377},{"id":"https://openalex.org/keywords/cell-size","display_name":"cell size","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ribosome-distribution","display_name":"ribosome distribution","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cross-walls","display_name":"cross walls","score":0.7289999723434448},{"id":"https://openalex.org/keywords/combination-antibiotic-therapy","display_name":"combination antibiotic therapy","score":0.578000009059906},{"id":"https://openalex.org/keywords/dna-fingerprinting","display_name":"DNA fingerprinting","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C2777677444","wikidata":"https://www.wikidata.org/wiki/Q140010","display_name":"Enterococcus faecium","level":3,"score":0.9451695680618286},{"id":"https://openalex.org/C2777874012","wikidata":"https://www.wikidata.org/wiki/Q5210829","display_name":"Dalfopristin","level":5,"score":0.9232183694839478},{"id":"https://openalex.org/C2780944852","wikidata":"https://www.wikidata.org/wiki/Q7272542","display_name":"Quinupristin","level":5,"score":0.8902633190155029},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.7923043370246887},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7498587965965271},{"id":"https://openalex.org/C2780585763","wikidata":"https://www.wikidata.org/wiki/Q517258","display_name":"Enterococcus","level":3,"score":0.5343270897865295},{"id":"https://openalex.org/C2779427427","wikidata":"https://www.wikidata.org/wiki/Q3560696","display_name":"Virginiamycin","level":3,"score":0.508461594581604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4200400710105896},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.4196828007698059},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2407158613204956},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.14179667830467224},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.12663203477859497},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.03618210554122925}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014769","descriptor_name":"Virginiamycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016984","descriptor_name":"Enterococcus faecium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016984","descriptor_name":"Enterococcus faecium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9675547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9675547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs under experimental and clinical research","raw_type":"Journal Article"},{"id":"mag:2460178047","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9675547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1965040120","https://openalex.org/W2098676114","https://openalex.org/W1991432772","https://openalex.org/W2153839778","https://openalex.org/W2077886622","https://openalex.org/W2168795525","https://openalex.org/W2122278405","https://openalex.org/W1501821309","https://openalex.org/W1519064016","https://openalex.org/W2100823325"],"abstract_inverted_index":{"Twenty":[0],"strains":[1,19,112,234],"of":[2,79,110,113,134,137,142,147,163,177,185,204,225],"Enterococcus":[3,114,148,189,221],"faecium":[4,115,149,190],"susceptible":[5,21],"to":[6,14,22,35,59,120,126,151,154,192,195,199,227,230,235,237],"quinupristin/dalfopristin":[7,45,121,205,226],"(<":[8],"2":[9,29],"mg/l)":[10,30],"were":[11,20,33,67,81,105,122,156],"DNA":[12],"fingerprinted":[13],"exclude":[15],"strain":[16],"duplication.":[17],"Ten":[18],"vancomycin":[23,36,152,155,193,196,207,228,238],"(minimal":[24],"inhibitory":[25],"concentration":[26],"[MIC]":[27],"<":[28,172],"and":[31,49,90,103,219],"10":[32,60],"resistant":[34,150],"(MIC":[37],">":[38],"400":[39],"mg/l).":[40],"Vancomycin":[41],"at":[42,46,99],"1/2":[43],"MIC,":[44],"1/4":[47],"MIC":[48],"their":[50],"combination,":[51],"except":[52],"for":[53,87,117],"a":[54],"tube":[55],"control,":[56,128],"was":[57,95],"added":[58],"ml":[61],"trypticase":[62,73],"soy":[63,74],"broth":[64,75],"tubes":[65],"which":[66],"planted":[68],"with":[69,161,211],"the":[70,127,140,143,159,200,232,240,245],"respective":[71],"24-h":[72],"cultures.":[76],"The":[77,108,145,202,223],"products":[78],"incubation":[80],"sampled":[82],"periodically":[83],"throughout":[84],"24":[85],"h":[86,119],"gram":[88],"stain":[89],"electron":[91],"microscopy.":[92],"Cell":[93],"size":[94,125],"measured":[96],"on":[97],"photographs":[98],"20,000x":[100],"final":[101],"magnification":[102],"results":[104],"statistically":[106],"analyzed.":[107],"cells":[109,146,175,210],"all":[111],"exposed":[116,153,194],"12":[118],"comparable":[123,198],"in":[124,139,216,239],"Most":[129],"cells,":[130],"however,":[131],"showed":[132],"areas":[133],"low":[135],"density":[136],"ribosome":[138],"center":[141],"cells.":[144],"larger":[157],"than":[158],"controls":[160],"means":[162],"1.96":[164],"micron":[165,167,170],"-2.07":[166],"versus":[168],"1.16":[169],"(p":[171],"0.001);":[173],"these":[174],"consisted":[176],"individual":[178],"organisms":[179],"connected":[180],"by":[181],"wide":[182],"cross":[183,214],"walls":[184,215],"abnormal":[186,213],"fibrous":[187],"structure.":[188],"sensitive":[191],"remained":[197],"control.":[201],"combination":[203],"plus":[206],"produced":[208],"large":[209],"multiple":[212],"both":[217],"vancomycin-resistant":[218,246],"vancomycin-sensitive":[220],"faecium.":[222],"addition":[224],"appears":[229],"modify":[231],"vancomycin-susceptible":[233],"respond":[236],"same":[241],"manner":[242],"as":[243],"do":[244],"organisms.":[247]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-07-22T00:00:00"}