{"id":"https://openalex.org/W246017306","doi":"https://doi.org/10.1182/blood.v76.1.105.105","title":"Receptor expression and functional status of cultured human eosinophils derived from umbilical cord blood mononuclear cells","display_name":"Receptor expression and functional status of cultured human eosinophils derived from umbilical cord blood mononuclear cells","publication_year":1990,"publication_date":"1990-07-01","ids":{"openalex":"https://openalex.org/W246017306","doi":"https://doi.org/10.1182/blood.v76.1.105.105","mag":"246017306","pmid":"https://pubmed.ncbi.nlm.nih.gov/1973060"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v76.1.105.105","doi":"https://doi.org/10.1182/blood.v76.1.105.105","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v76.1.105.105","pdf_url":"https://ashpublications.org/blood/article-pdf/76/1/105/603733/105.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/76/1/105/603733/105.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024936437","display_name":"Garry M. Walsh","orcid":"https://orcid.org/0000-0002-7138-4078","observed_orcids":["https://orcid.org/0000-0002-7138-4078"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"GM Walsh","raw_affiliation_strings":["Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000219202","display_name":"Adele Hartnell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Hartnell","raw_affiliation_strings":["Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086948999","display_name":"Redwan Moqbel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Moqbel","raw_affiliation_strings":["Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074378770","display_name":"Oliver Cromwell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Cromwell","raw_affiliation_strings":["Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112159197","display_name":"L Nagy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Nagy","raw_affiliation_strings":["Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062127205","display_name":"Burton Bradley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Bradley","raw_affiliation_strings":["Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051919501","display_name":"T Furitsu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Furitsu","raw_affiliation_strings":["Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079721068","display_name":"Teruko Ishizaka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Ishizaka","raw_affiliation_strings":["Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113998589","display_name":"A. Barry Kay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AB Kay","raw_affiliation_strings":["Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":5.6471,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.95984497,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"76","issue":"1","first_page":"105","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/umbilical-cord-blood-mononuclear-cells","display_name":"umbilical cord blood mononuclear cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/lfa-1","display_name":"LFA-1","score":0.7480000257492065},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.9259999990463257},{"id":"https://openalex.org/keywords/platelet-activating-factor","display_name":"platelet-activating factor","score":0.8349999785423279},{"id":"https://openalex.org/keywords/eosinophil-chemotaxis","display_name":"eosinophil chemotaxis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/rosette-formation","display_name":"rosette formation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/eosinophil-adhesion","display_name":"eosinophil adhesion","score":0.8209999799728394},{"id":"https://openalex.org/keywords/leukotriene-c4","display_name":"leukotriene C4","score":0.8349999785423279},{"id":"https://openalex.org/keywords/eosinophil-peroxidase","display_name":"eosinophil peroxidase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/eosinophil-function","display_name":"eosinophil function","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6375622749328613},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.568555474281311},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5290231704711914},{"id":"https://openalex.org/C2779020240","wikidata":"https://www.wikidata.org/wiki/Q420577","display_name":"Platelet-activating factor","level":2,"score":0.47949081659317017},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.45400193333625793},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44928431510925293},{"id":"https://openalex.org/C2780914630","wikidata":"https://www.wikidata.org/wiki/Q914952","display_name":"Cord blood","level":2,"score":0.44337964057922363},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.43623876571655273},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4262208342552185},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4216720461845398},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35423582792282104},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2404915988445282},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16029810905456543},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007142","descriptor_name":"Immunoglobulin gamma-Chains","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007142","descriptor_name":"Immunoglobulin gamma-Chains","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012397","descriptor_name":"Rosette Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012550","descriptor_name":"Schistosoma mansoni","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013189","descriptor_name":"SRS-A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015923","descriptor_name":"Complement C1r","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015923","descriptor_name":"Complement C1r","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015926","descriptor_name":"Complement C3a","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015926","descriptor_name":"Complement C3a","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016028","descriptor_name":"Receptors, Leukocyte-Adhesion","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016028","descriptor_name":"Receptors, Leukocyte-Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016167","descriptor_name":"Integrin alphaXbeta2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016169","descriptor_name":"Lymphocyte Function-Associated Antigen-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v76.1.105.105","doi":"https://doi.org/10.1182/blood.v76.1.105.105","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v76.1.105.105","pdf_url":"https://ashpublications.org/blood/article-pdf/76/1/105/603733/105.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v76.1.105.bloodjournal761105","doi":"https://doi.org/10.1182/blood.v76.1.105.bloodjournal761105","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v76.1.105.bloodjournal761105","pdf_url":"https://ashpublications.org/blood/article-pdf/76/1/105/219371/105.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:1973060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1973060","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood.v76.1.105.105","doi":"https://doi.org/10.1182/blood.v76.1.105.105","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v76.1.105.105","pdf_url":"https://ashpublications.org/blood/article-pdf/76/1/105/603733/105.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2601213243","display_name":null,"funder_award_id":"AI10060","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W246017306.pdf","grobid_xml":"https://content.openalex.org/works/W246017306.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1537722281","https://openalex.org/W1572415265","https://openalex.org/W1906008355","https://openalex.org/W1984324451","https://openalex.org/W1990075382","https://openalex.org/W2011658825","https://openalex.org/W2013396311","https://openalex.org/W2032568564","https://openalex.org/W2033790133","https://openalex.org/W2037663265","https://openalex.org/W2066006226","https://openalex.org/W2066609296","https://openalex.org/W2067497365","https://openalex.org/W2072425850","https://openalex.org/W2075357817","https://openalex.org/W2090893983","https://openalex.org/W2099865106","https://openalex.org/W2106068114","https://openalex.org/W2112217048","https://openalex.org/W2146851076","https://openalex.org/W2152311269","https://openalex.org/W2418712387","https://openalex.org/W2463284912","https://openalex.org/W2475267842"],"related_works":["https://openalex.org/W2094986337","https://openalex.org/W2086539029","https://openalex.org/W1963855124","https://openalex.org/W1989506293","https://openalex.org/W2119817843","https://openalex.org/W2092127298","https://openalex.org/W1969295726","https://openalex.org/W2048312858","https://openalex.org/W7100051781","https://openalex.org/W2050708037"],"abstract_inverted_index":{"Selective":[0],"use":[1,26],"of":[2,10,13,24,30,46,59,102,132,139,158,172,204,223,258,264],"recombinant":[3],"human":[4,16],"cytokines":[5,266],"has":[6],"enabled":[7],"the":[8,22,67,152,170,213,262,265],"culture":[9],"large":[11],"numbers":[12,101],"eosinophils":[14,34,42],"from":[15],"cord":[17],"blood":[18,41],"mononuclear":[19],"cells,":[20],"raising":[21],"possibility":[23],"their":[25,47,259,269],"as":[27],"a":[28,93,256],"model":[29],"eosinophil":[31,224],"function.":[32,52],"Cultured":[33],"(CE)":[35],"were":[36],"compared":[37,84],"with":[38,85,163,198,217],"normal-density":[39],"peripheral":[40],"(PBE)":[43],"in":[44,89,92,130,210,247,268],"terms":[45,131],"membrane":[48],"receptor":[49],"expression":[50,58],"and":[51,56,61,77,105,113,119,127,136,145,174,231,239,244],"Fc":[53],"gamma":[54],"R":[55],"CR1":[57],"CE":[60,83,87,98,118,144,159,165,185,196,230,238],"PBE":[62,120,146,240],"was":[63,79,150,160,227],"similar.":[64],"In":[65],"contrast,":[66],"specific":[68],"mean":[69],"fluorescence":[70],"for":[71,82,229],"LFA-1":[72],"alpha,":[73,75],"p150,95":[74],"ICAM-1,":[76],"HLA-DR":[78],"significantly":[80],"elevated":[81],"PBE.":[86,97,117,218,232],"responded":[88],"PAF-induced":[90,137],"chemotaxis":[91],"similar":[94,228],"fashion":[95],"to":[96,124,147,192],"gave":[99],"higher":[100],"both":[103,133],"resting":[104],"platelet":[106],"activating":[107],"factor":[108],"(PAF)-stimulated":[109],"immunoglobulin":[110],"G":[111],"(IgG)-":[112],"C3b-dependent":[114],"rosettes":[115],"than":[116,168],"had":[121],"comparable":[122],"capacity":[123],"kill":[125],"IgG-":[126],"C-opsonized":[128],"schistosomula":[129],"baseline":[134],"values":[135],"enhancement":[138],"cytotoxicity.":[140],"Baseline":[141],"adherence":[142],"by":[143,178],"plasma-coated":[148],"glass":[149],"essentially":[151],"same,":[153],"but":[154],"stimulated":[155,197],"adhesion":[156],"(PAF)":[157],"lower.":[161],"Compared":[162],"PBE,":[164,184],"generated":[166,201],"less":[167],"half":[169,212],"amounts":[171],"extracellular":[173],"cell-associated":[175],"PAF":[176,189],"induced":[177],"calcium":[179],"ionophore":[180],"A23187":[181,207],"stimulation.":[182],"Unlike":[183],"did":[186],"not":[187],"generate":[188],"after":[190],"exposure":[191],"IgG-coated":[193,199],"Sepharose":[194],"particles.":[195],"beads":[200],"small":[202],"quantities":[203],"LTC4,":[205],"while":[206],"stimulation":[208],"resulted":[209],"approximately":[211],"LTC4":[214],"levels":[215],"observed":[216],"The":[219],"total":[220],"cell":[221],"content":[222],"peroxidase":[225],"(EPO)":[226],"These":[233],"data":[234],"suggest":[235],"that":[236,253],"although":[237],"have":[241],"many":[242],"phenotypic":[243],"functional":[245],"properties":[246],"common":[248],"there":[249],"are":[250],"quantitative":[251],"differences":[252],"may":[254],"be":[255],"consequence":[257],"immaturity":[260],"and/or":[261],"influence":[263],"used":[267],"culture.":[270]},"counts_by_year":[{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}