{"id":"https://openalex.org/W2460132622","doi":null,"title":"Parasitemia Induces High Plasma Levels of Interleukin-17 (IL-17) and Low Levels of Interleukin-10 (IL-10) and Transforming Growth Factor-\u00df (TGF-\u00df) in Pregnant Mice Infected with Malaria.","display_name":"Parasitemia Induces High Plasma Levels of Interleukin-17 (IL-17) and Low Levels of Interleukin-10 (IL-10) and Transforming Growth Factor-\u00df (TGF-\u00df) in Pregnant Mice Infected with Malaria.","publication_year":2015,"publication_date":"2015-05-01","ids":{"openalex":"https://openalex.org/W2460132622","mag":"2460132622","pmid":"https://pubmed.ncbi.nlm.nih.gov/26715893","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4681718"},"language":"en","primary_location":{"id":"pmid:26715893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26715893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Malaysian journal of medical sciences : MJMS","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4681718/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001317043","display_name":"Zainabur Rahmah","orcid":"https://orcid.org/0000-0003-0232-6891","observed_orcids":["https://orcid.org/0000-0003-0232-6891"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Zainabur Rahmah","raw_affiliation_strings":["Doctoral Program in Medical Science, Faculty of Medicine, Universitas Brawijaya, Jalan Veteran Malang, East Java 65145, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctoral Program in Medical Science, Faculty of Medicine, Universitas Brawijaya, Jalan Veteran Malang, East Java 65145, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020483435","display_name":"Sujarot Dwi Sasmito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Sujarot Dwi Sasmito","raw_affiliation_strings":["Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Brawijaya, Jalan Veteran Malang, East Java 65145, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Brawijaya, Jalan Veteran Malang, East Java 65145, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019923643","display_name":"Budi Siswanto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Budi Siswanto","raw_affiliation_strings":["Department of Obstetric and Gynecology, Faculty of Medicine Universitas Brawijaya, Jalan Jaksa Agung Suprapto, No. 2 Malang, East Java, 65122, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetric and Gynecology, Faculty of Medicine Universitas Brawijaya, Jalan Jaksa Agung Suprapto, No. 2 Malang, East Java, 65122, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074832481","display_name":"Teguh Wahju Sardjono","orcid":"https://orcid.org/0000-0001-6727-0361","observed_orcids":["https://orcid.org/0000-0001-6727-0361"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Teguh Wahju Sardjono","raw_affiliation_strings":["Department of Parasitology Faculty of Medicine Universitas Brawijaya, Jalan Veteran Malang, East Java, 65145, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Parasitology Faculty of Medicine Universitas Brawijaya, Jalan Veteran Malang, East Java, 65145, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046357013","display_name":"Loeki Enggar Fitri","orcid":"https://orcid.org/0000-0002-4880-1048","observed_orcids":["https://orcid.org/0000-0002-4880-1048"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Loeki Enggar Fitri","raw_affiliation_strings":["Department of Parasitology Faculty of Medicine Universitas Brawijaya, Jalan Veteran Malang, East Java, 65145, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Parasitology Faculty of Medicine Universitas Brawijaya, Jalan Veteran Malang, East Java, 65145, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I177055848"],"apc_list":null,"apc_paid":null,"fwci":1.7183,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.83894767,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"22","issue":"3","first_page":"25","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malaria-in-pregnancy","display_name":"malaria in pregnancy","score":0.8309999704360962},{"id":"https://openalex.org/keywords/plasmodium-berghei","display_name":"Plasmodium berghei","score":0.9700000286102295},{"id":"https://openalex.org/keywords/parasitemia","display_name":"parasitemia","score":0.9589999914169312},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.9959999918937683},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":1.0},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9850000143051147},{"id":"https://openalex.org/keywords/immune-response-to-malaria","display_name":"immune response to malaria","score":0.5070000290870667},{"id":"https://openalex.org/keywords/pregnancy-immunology","display_name":"pregnancy immunology","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C2775867548","wikidata":"https://www.wikidata.org/wiki/Q1897162","display_name":"Parasitemia","level":4,"score":0.8412730693817139},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.680691659450531},{"id":"https://openalex.org/C187316574","wikidata":"https://www.wikidata.org/wiki/Q423698","display_name":"Interleukin 10","level":3,"score":0.5270954370498657},{"id":"https://openalex.org/C2777495146","wikidata":"https://www.wikidata.org/wiki/Q1889778","display_name":"Trophoblast","level":5,"score":0.5157487988471985},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.5059365630149841},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.498913049697876},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4898912310600281},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.4870224595069885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47606414556503296},{"id":"https://openalex.org/C2777237215","wikidata":"https://www.wikidata.org/wiki/Q65021","display_name":"Plasmodium berghei","level":3,"score":0.440534383058548},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4295884966850281},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42712998390197754},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39489489793777466},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3524782061576843},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3489592373371124},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3313426375389099},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2968680262565613},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.13355708122253418},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.13240012526512146},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.08636400103569031},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmid:26715893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26715893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Malaysian journal of medical sciences : MJMS","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4681718","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4681718/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malays J Med Sci","raw_type":"Text"},{"id":"pmh:oai:repository.uin-malang.ac.id:3503","doi":null,"is_oa":false,"landing_page_url":"http://repository.uin-malang.ac.id/3503/1/3503.pdf","pdf_url":"http://repository.uin-malang.ac.id/3503/1/3503.pdf","source":{"id":"https://openalex.org/S4306400437","display_name":"Research Repository Universitas Islam Negeri Maulana Malik Ibrahim (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:cria:bioline:mj:mj15029","doi":null,"is_oa":true,"landing_page_url":"http://www.bioline.org.br/abstract?id=mj15029","pdf_url":"http://www.bioline.org.br/abstract?id=mj15029","source":{"id":"https://openalex.org/S4306402188","display_name":"Bioline International (Bioline International)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Malaysian Journal of Medical Sciences (ISSN: 1394-195X) Vol 22 Num 3","raw_type":"AA"},{"id":"mag:2460132622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26715893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4681718","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4681718/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malays J Med Sci","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323817","display_name":"Universitas Brawijaya","ror":"https://ror.org/01wk3d929"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2460132622.pdf","grobid_xml":"https://content.openalex.org/works/W2460132622.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1498159349","https://openalex.org/W1666957925","https://openalex.org/W1985201708","https://openalex.org/W1987147264","https://openalex.org/W1998858806","https://openalex.org/W2005470158","https://openalex.org/W2007603900","https://openalex.org/W2008775556","https://openalex.org/W2012114706","https://openalex.org/W2022179150","https://openalex.org/W2029393400","https://openalex.org/W2094230544","https://openalex.org/W2096731679","https://openalex.org/W2098423140","https://openalex.org/W2119879093","https://openalex.org/W2120356605","https://openalex.org/W2124232678","https://openalex.org/W2125930156","https://openalex.org/W2138514282","https://openalex.org/W2153366331","https://openalex.org/W2160258620","https://openalex.org/W2166495198","https://openalex.org/W2167223311","https://openalex.org/W2168588771","https://openalex.org/W2191654227"],"related_works":["https://openalex.org/W2045081576","https://openalex.org/W2093780644","https://openalex.org/W2119672443","https://openalex.org/W2118487354","https://openalex.org/W1972185907","https://openalex.org/W2942382741","https://openalex.org/W2553051250","https://openalex.org/W2149610060","https://openalex.org/W1991571057","https://openalex.org/W4386193337"],"abstract_inverted_index":{"BACKGROUND:":[0],"During":[1],"pregnancy,":[2],"the":[3,7,20,25,28,39,50,56,64,123,127,135,145,153,165,178,183,204,209,221,226,231],"balanced":[4],"dominance":[5],"of":[6,22,27,41,52,58,66,109,180,201],"T":[8],"helper17":[9],"response":[10,15],"shifts":[11],"to":[12],"a":[13,198],"Th2":[14],"that":[16,197],"is":[17,36],"characterised":[18],"by":[19,104,116,224],"production":[21],"IL-10,":[23,60,111],"following":[24],"completion":[26,40],"implantation":[29],"process.":[30],"Transforming":[31],"growth":[32],"factor-\u03b2":[33],"(TGF-\u03b2)":[34],"expression":[35],"associated":[37],"with":[38,69,83,220],"trophoblast":[42],"invasion":[43],"and":[44,61,88,112,207,211,229,233],"placental":[45],"growth.":[46],"This":[47],"study":[48],"assessed":[49],"effect":[51],"malaria":[53],"infection":[54,216],"on":[55,97],"levels":[57,108,125,143,167,186,206,228],"IL-17,":[59,110],"TGF-\u03b2":[62,113,166,185,212,234],"in":[63,126,134,144,152,164],"plasma":[65,184],"pregnant":[67,73],"mice":[68,75,81,90,94],"malaria.":[70],"METHODS:":[71],"Seventeen":[72],"BALB/C":[74],"were":[76,95,114,130,148],"divided":[77],"into":[78],"two":[79,172],"groups:":[80],"infected":[82],"Plasmodium":[84],"berghei":[85],"(treatment":[86],"group)":[87],"uninfected":[89],"(control":[91],"group).":[92],"The":[93,107,141],"sacrificed":[96],"day":[98],"18":[99],"post-mating.":[100],"Parasitemia":[101],"was":[102,160],"measured":[103,115],"Giemsa":[105],"staining.":[106],"ELISA.":[117],"RESULTS:":[118],"Using":[119],"independent":[120],"t":[121],"test,":[122],"IL-17":[124,205,227],"treatment":[128,146],"group":[129,137,147,155],"higher":[131],"than":[132,150],"those":[133,151],"control":[136,154],"(=":[138,156,168],"=":[139,157,169,188,192],"0.040).":[140],"IL-10":[142,210,232],"lower":[149],"0.00).":[158],"There":[159],"no":[161],"significant":[162],"difference":[163],"0.055)":[170],"between":[171],"groups.":[173],"However,":[174],"using":[175],"SEM":[176,194],"analysis":[177,195],"degree":[179,200],"parasitemia":[181,202],"decreased":[182,208],"(tcount":[187],"5.148;":[189],"\u2265":[190],"ttable":[191],"1.96).":[193],"showed":[196],"high":[199],"increased":[203],"levels.":[213,235],"CONCLUSION:":[214],"Malaria":[215],"during":[217],"pregnancy":[218],"interferes":[219],"systemic":[222],"balance":[223],"increasing":[225],"decreasing":[230]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-07-22T00:00:00"}