{"id":"https://openalex.org/W2458686","doi":null,"title":"Preterm Cervical Ripening in humans.","display_name":"Preterm Cervical Ripening in humans.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2458686","mag":"2458686","pmid":"https://pubmed.ncbi.nlm.nih.gov/24753916","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3987477"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3987477","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3987477/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3987477/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Facts Views Vis Obgyn","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3987477/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013410109","display_name":"Gunvor E. Ekman-Ordeberg","orcid":"https://orcid.org/0000-0002-5182-2317","observed_orcids":["https://orcid.org/0000-0002-5182-2317"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"G Ekman-Ordeberg","raw_affiliation_strings":["Department of Womens and Childrens' Health, Division of Obstetrics and Gynecology, Karolinska Institute, 171 76 Stockholm"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Womens and Childrens' Health, Division of Obstetrics and Gynecology, Karolinska Institute, 171 76 Stockholm","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024865638","display_name":"Aurelija Dubicke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A Dubicke","raw_affiliation_strings":["Department of Womens and Childrens' Health, Division of Obstetrics and Gynecology, Karolinska Institute, 171 76 Stockholm"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Womens and Childrens' Health, Division of Obstetrics and Gynecology, Karolinska Institute, 171 76 Stockholm","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.00033799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"4","issue":"4","first_page":"245","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cervical-ripening","display_name":"cervical ripening","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cervical-epithelium","display_name":"cervical epithelium","score":0.7269999980926514},{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.734000027179718},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9359999895095825},{"id":"https://openalex.org/keywords/crh-receptors","display_name":"CRH receptors","score":0.7670000195503235},{"id":"https://openalex.org/keywords/toll-like-receptors","display_name":"Toll-like receptors","score":0.878000020980835},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9190000295639038},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9980000257492065},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8190000057220459},{"id":"https://openalex.org/keywords/preterm-labour","display_name":"preterm labour","score":0.781000018119812},{"id":"https://openalex.org/keywords/preterm-premature-rupture-of-membranes","display_name":"preterm premature rupture of membranes","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C172353545","wikidata":"https://www.wikidata.org/wiki/Q2121926","display_name":"Ripening","level":2,"score":0.7472162246704102},{"id":"https://openalex.org/C2777740455","wikidata":"https://www.wikidata.org/wiki/Q666412","display_name":"Cervix","level":3,"score":0.649785041809082},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6238588094711304},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5215446949005127},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.4862271845340729},{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.46628451347351074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31692251563072205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24449792504310608},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1089271605014801},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3987477","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3987477/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3987477/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Facts Views Vis Obgyn","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2970597","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3987477","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:24753916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24753916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Facts, views & vision in ObGyn","raw_type":"Journal Article"},{"id":"mag:2458686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24753916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3987477","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3987477/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3987477/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Facts Views Vis Obgyn","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2458686.pdf","grobid_xml":"https://content.openalex.org/works/W2458686.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W11848839","https://openalex.org/W1768003048","https://openalex.org/W1832131361","https://openalex.org/W1968285353","https://openalex.org/W1973429877","https://openalex.org/W1975755498","https://openalex.org/W1983927722","https://openalex.org/W1984650879","https://openalex.org/W1985289222","https://openalex.org/W1990041723","https://openalex.org/W1995446363","https://openalex.org/W1995684652","https://openalex.org/W1995688961","https://openalex.org/W1996272233","https://openalex.org/W1998744636","https://openalex.org/W2003117475","https://openalex.org/W2004011257","https://openalex.org/W2004660440","https://openalex.org/W2005244375","https://openalex.org/W2011567980","https://openalex.org/W2015204889","https://openalex.org/W2018097513","https://openalex.org/W2018653121","https://openalex.org/W2019500639","https://openalex.org/W2019535046","https://openalex.org/W2029795921","https://openalex.org/W2039012256","https://openalex.org/W2040915791","https://openalex.org/W2043985387","https://openalex.org/W2043991526","https://openalex.org/W2045248898","https://openalex.org/W2058717856","https://openalex.org/W2059587221","https://openalex.org/W2065999431","https://openalex.org/W2068372702","https://openalex.org/W2074925828","https://openalex.org/W2075744199","https://openalex.org/W2075915970","https://openalex.org/W2081592120","https://openalex.org/W2082422233","https://openalex.org/W2082887126","https://openalex.org/W2085213100","https://openalex.org/W2090921011","https://openalex.org/W2094539548","https://openalex.org/W2098994805","https://openalex.org/W2101718441","https://openalex.org/W2106620350","https://openalex.org/W2109590683","https://openalex.org/W2111678567","https://openalex.org/W2116628722","https://openalex.org/W2119763663","https://openalex.org/W2125321080","https://openalex.org/W2131923919","https://openalex.org/W2134020942","https://openalex.org/W2138133369","https://openalex.org/W2140338740","https://openalex.org/W2141030191","https://openalex.org/W2145388421","https://openalex.org/W2147688308","https://openalex.org/W2148151469","https://openalex.org/W2149658596","https://openalex.org/W2150365936","https://openalex.org/W2150982004","https://openalex.org/W2158124686","https://openalex.org/W2158482164","https://openalex.org/W2161017032","https://openalex.org/W2161359206","https://openalex.org/W2163861766","https://openalex.org/W2164197794","https://openalex.org/W2164714222","https://openalex.org/W2165380904","https://openalex.org/W2165960320","https://openalex.org/W2166410538","https://openalex.org/W2168878247","https://openalex.org/W2169849048","https://openalex.org/W2171028311","https://openalex.org/W2397515233","https://openalex.org/W2418730583","https://openalex.org/W2421300819","https://openalex.org/W2628053793"],"related_works":["https://openalex.org/W6995828959","https://openalex.org/W7020748322","https://openalex.org/W1501464655","https://openalex.org/W2040752427","https://openalex.org/W2471132029","https://openalex.org/W2041099171","https://openalex.org/W2152244013","https://openalex.org/W4206520815","https://openalex.org/W2165380904","https://openalex.org/W2142179241"],"abstract_inverted_index":{"Preterm":[0],"birth":[1],"(PTB)":[2],"is":[3,40,49,60,168,176,229],"the":[4,13,17,25,32,41,86,111,119,150,193],"leading":[5],"cause":[6],"of":[7,19,31,56,121,155,195,198,208,218],"neonatal":[8],"mortality":[9],"and":[10,34,54,73,77,80,88,134,166,202,204,213,244],"morbidity.":[11],"Despite":[12],"current":[14],"treatment":[15,65],"procedures,":[16],"incidence":[18],"PTB":[20],"has":[21],"not":[22],"changed":[23],"in":[24,85,92,110,118,149,192,210,242],"past":[26],"thirty":[27],"years.":[28],"Incomplete":[29],"understanding":[30,55],"biological":[33],"patophysiological":[35],"mechanisms":[36],"underlying":[37],"preterm":[38,57,133,167,179,222,226,246],"delivery":[39,53,227],"major":[42,145],"obstacle":[43],"to":[44],"prevent":[45],"PTB.":[46],"Cervical":[47],"ripening":[48,59,123,162,181],"necessary":[50],"for":[51,62,190],"vaginal":[52],"cervical":[58,112,122,136,161,180,188,211,219,223],"required":[61],"developing":[63],"new":[64],"strategies.":[66],"Several":[67],"important":[68,95],"substances":[69],"such":[70,97],"as":[71,98],"HMGB1":[72],"its":[74,78],"receptors,":[75],"CRH":[76,127],"receptors":[79,200],"numerous":[81],"cytokines":[82],"are":[83,108,236],"localized":[84,109],"cervix":[87,151],"undergo":[89],"distinct":[90],"changes":[91,147],"labour.":[93,125,247],"Other":[94],"-molecules,":[96],"CRH,":[99],"CRH-BP,":[100],"CRH-R1,":[101],"CRH-R2,":[102],"HMGB1,":[103],"TLR2,":[104],"TLR4,":[105],"IL-10,":[106],"IL-12,":[107,205],"epithelium,":[113,212],"also":[114],"indicating":[115],"their":[116],"role":[117],"process":[120,171],"during":[124],"Furthermore,":[126],"stimulates":[128],"IL-8":[129],"secretion":[130,216],"from":[131,140,186,239],"both":[132,164],"term":[135,165,187],"fibroblasts.":[137,220],"Recent":[138],"studies":[139],"our":[141],"group":[142],"show":[143],"that":[144,160],"-inflammatory":[146],"occur":[148],"at":[152,163],"labour":[153],"irrespective":[154],"gestational":[156],"age.":[157],"This":[158],"indicates":[159],"an":[169],"inflammatory":[170],"even":[172],"if":[173],"no":[174],"infection":[175],"present.":[177],"However,":[178],"still":[182],"entails":[183],"some":[184],"differences":[185],"ripening,":[189,224],"example":[191],"down-regulation":[194],"mRNA":[196],"expression":[197],"Toll-like":[199],"(TLR-2":[201],"TLR-4)":[203],"higher":[206],"levels":[207],"IL-10":[209],"presents":[214],"different":[215,238],"patterns":[217],"Moreover,":[221],"like":[225],"itself,":[228],"a":[230],"multifactorial":[231],"disorder":[232],"with":[233],"pathways":[234],"which":[235],"partly":[237],"those":[240],"involved":[241],"PPROM":[243],"infected":[245]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
