{"id":"https://openalex.org/W245860210","doi":"https://doi.org/10.1016/0016-5085(85)90002-2","title":"Degradative intracellular transport of antisecretory component in cultured hepatocytes","display_name":"Degradative intracellular transport of antisecretory component in cultured hepatocytes","publication_year":1985,"publication_date":"1985-06-01","ids":{"openalex":"https://openalex.org/W245860210","doi":"https://doi.org/10.1016/0016-5085(85)90002-2","mag":"245860210","pmid":"https://pubmed.ncbi.nlm.nih.gov/3873370"},"language":"en","primary_location":{"id":"doi:10.1016/0016-5085(85)90002-2","doi":"https://doi.org/10.1016/0016-5085(85)90002-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0016-5085(85)90002-2","pdf_url":"https://doi.org/10.1016/0016-5085(85)90002-2","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/0016-5085(85)90002-2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100728167","display_name":"Edward Jae-Hoon Kim","orcid":"https://orcid.org/0000-0002-8660-7465","observed_orcids":["https://orcid.org/0000-0002-8660-7465"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Kim","raw_affiliation_strings":["Cell Biology and Aging Section and the Intestinal Immunology Research Center, Veterans Administration Medical Center, Departments of Anatomy and Medicine and the Liver Center, University of California, San Francisco, California","Cell Biology and Aging Section (15lE), Veterans Administration Hospital, 4150 Clement Street, San Francisco, California 94121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Aging Section and the Intestinal Immunology Research Center, Veterans Administration Medical Center, Departments of Anatomy and Medicine and the Liver Center, University of California, San Francisco, California","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191"]},{"raw_affiliation_string":"Cell Biology and Aging Section (15lE), Veterans Administration Hospital, 4150 Clement Street, San Francisco, California 94121","institution_ids":["https://openalex.org/I1315708478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111577972","display_name":"Gary T. Hradek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary T. Hradek","raw_affiliation_strings":["Cell Biology and Aging Section and the Intestinal Immunology Research Center, Veterans Administration Medical Center, Departments of Anatomy and Medicine and the Liver Center, University of California, San Francisco, California","Cell Biology and Aging Section (15lE), Veterans Administration Hospital, 4150 Clement Street, San Francisco, California 94121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Aging Section and the Intestinal Immunology Research Center, Veterans Administration Medical Center, Departments of Anatomy and Medicine and the Liver Center, University of California, San Francisco, California","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191"]},{"raw_affiliation_string":"Cell Biology and Aging Section (15lE), Veterans Administration Hospital, 4150 Clement Street, San Francisco, California 94121","institution_ids":["https://openalex.org/I1315708478"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109319134","display_name":"Albert L. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert L. Jones","raw_affiliation_strings":["Cell Biology and Aging Section (15lE), Veterans Administration Hospital, 4150 Clement Street, San Francisco, California 94121","Cell Biology and Aging Section and the Intestinal Immunology Research Center, Veterans Administration Medical Center, Departments of Anatomy and Medicine and the Liver Center, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Aging Section (15lE), Veterans Administration Hospital, 4150 Clement Street, San Francisco, California 94121","institution_ids":["https://openalex.org/I1315708478"]},{"raw_affiliation_string":"Cell Biology and Aging Section and the Intestinal Immunology Research Center, Veterans Administration Medical Center, Departments of Anatomy and Medicine and the Liver Center, University of California, San Francisco, California","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":null,"fwci":0.1659,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.41065483,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"88","issue":"6","first_page":"1791","last_page":"1798"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secretory-component","display_name":"secretory component","score":0.9829999804496765},{"id":"https://openalex.org/keywords/bile-secretion","display_name":"bile secretion","score":0.5519999861717224},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.7739999890327454},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.828000009059906},{"id":"https://openalex.org/keywords/coated-vesicles","display_name":"coated vesicles","score":0.8980000019073486},{"id":"https://openalex.org/keywords/multivesicular-bodies","display_name":"multivesicular bodies","score":0.8870000243186951},{"id":"https://openalex.org/keywords/secretory-iga","display_name":"secretory IgA","score":0.6629999876022339},{"id":"https://openalex.org/keywords/antibody-internalization","display_name":"antibody internalization","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C2777676563","wikidata":"https://www.wikidata.org/wiki/Q413665","display_name":"Horseradish peroxidase","level":3,"score":0.8748025298118591},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6536644697189331},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.6307413578033447},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.5963649749755859},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5204130411148071},{"id":"https://openalex.org/C2777068557","wikidata":"https://www.wikidata.org/wiki/Q7444455","display_name":"Secretory component","level":3,"score":0.5100758671760559},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5045937299728394},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4897606372833252},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.46975067257881165},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.46814873814582825},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.4678279757499695},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3991287350654602},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3875257670879364},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.348366916179657},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1590573787689209},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1465432345867157},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10849472880363464}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000888","descriptor_name":"Antibodies, Anti-Idiotypic","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001666","descriptor_name":"Binding Sites, Antibody","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001826","descriptor_name":"Body Fluids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007071","descriptor_name":"Immunoglobulin A, Secretory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007128","descriptor_name":"Immunoglobulin Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012635","descriptor_name":"Secretory Component","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/0016-5085(85)90002-2","doi":"https://doi.org/10.1016/0016-5085(85)90002-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0016-5085(85)90002-2","pdf_url":"https://doi.org/10.1016/0016-5085(85)90002-2","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},{"id":"pmid:3873370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3873370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"Journal Article"},{"id":"mag:3026593801","doi":null,"is_oa":false,"landing_page_url":"http://linkinghub.elsevier.com/retrieve/pii/0016508585900022","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Gastroenterology","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/0016-5085(85)90002-2","doi":"https://doi.org/10.1016/0016-5085(85)90002-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0016-5085(85)90002-2","pdf_url":"https://doi.org/10.1016/0016-5085(85)90002-2","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3014545475","display_name":"LIVER CORE CENTER","funder_award_id":"2p30am026743-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3732600681","display_name":"INTESTINAL IMMUNE RESPONSE: REGULATION AND MECHANISMS","funder_award_id":"5p01am033004-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5068650954","display_name":"SUBCELLULAR STUDY OF BILE SECRETION","funder_award_id":"5r01am025878-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320311351","display_name":"American Gastroenterological Association","ror":"https://ror.org/00y65x556"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W245860210.pdf","grobid_xml":"https://content.openalex.org/works/W245860210.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W9029289","https://openalex.org/W297921291","https://openalex.org/W1542726031","https://openalex.org/W1775749144","https://openalex.org/W1803989168","https://openalex.org/W1966940381","https://openalex.org/W1971389550","https://openalex.org/W1973301075","https://openalex.org/W1981284040","https://openalex.org/W1986208323","https://openalex.org/W1990040067","https://openalex.org/W1997171790","https://openalex.org/W2006387884","https://openalex.org/W2013772013","https://openalex.org/W2029287429","https://openalex.org/W2030655780","https://openalex.org/W2046846652","https://openalex.org/W2046890061","https://openalex.org/W2073143598","https://openalex.org/W2074381499","https://openalex.org/W2076651840","https://openalex.org/W2079687293","https://openalex.org/W2079772188","https://openalex.org/W2085112043","https://openalex.org/W2085649019","https://openalex.org/W2086134276","https://openalex.org/W2088396190","https://openalex.org/W2100075764","https://openalex.org/W2119726256","https://openalex.org/W2141376249","https://openalex.org/W2157505237","https://openalex.org/W2164188238","https://openalex.org/W2275166293"],"related_works":["https://openalex.org/W1804141833","https://openalex.org/W1973301075","https://openalex.org/W2136726013","https://openalex.org/W1997060445","https://openalex.org/W1974429500","https://openalex.org/W2013772013","https://openalex.org/W2111278472","https://openalex.org/W2155795884","https://openalex.org/W1975518422","https://openalex.org/W1986208323"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}