{"id":"https://openalex.org/W245217128","doi":null,"title":"Targeting histone deacetylase in lung cancer for early diagnosis: (18)F-FAHA PET/CT imaging of NNK-treated A/J mice model.","display_name":"Targeting histone deacetylase in lung cancer for early diagnosis: (18)F-FAHA PET/CT imaging of NNK-treated A/J mice model.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W245217128","mag":"245217128","pmid":"https://pubmed.ncbi.nlm.nih.gov/24982818","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4074498"},"language":"en","primary_location":{"id":"pmid:24982818","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24982818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of nuclear medicine and molecular imaging","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4074498/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112179461","display_name":"Wayland Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayland Tang","raw_affiliation_strings":["Preclinical Imaging, Department of Radiological Sciences, University of California Irvine, California 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Imaging, Department of Radiological Sciences, University of California Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062337137","display_name":"Sharon A. Kuruvilla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon A Kuruvilla","raw_affiliation_strings":["Preclinical Imaging, Department of Radiological Sciences, University of California Irvine, California 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Imaging, Department of Radiological Sciences, University of California Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012958347","display_name":"Valentin Galitovskiy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valentin Galitovskiy","raw_affiliation_strings":["Cancer Center and Research Institute, University of California Irvine, California 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center and Research Institute, University of California Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100870412","display_name":"Min\u2010Liang Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min-Liang Pan","raw_affiliation_strings":["Preclinical Imaging, Department of Radiological Sciences, University of California Irvine, California 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Imaging, Department of Radiological Sciences, University of California Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059337810","display_name":"Sergei A. Grando","orcid":"https://orcid.org/0000-0001-5769-8938","observed_orcids":["https://orcid.org/0000-0001-5769-8938"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergei A Grando","raw_affiliation_strings":["Department of Dermatology, University of California Irvine, California 92697, USA ; Cancer Center and Research Institute, University of California Irvine, California 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of California Irvine, California 92697, USA ; Cancer Center and Research Institute, University of California Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111560124","display_name":"Jogeshwar Mukherjee","orcid":"https://orcid.org/0000-0003-1009-877X","observed_orcids":["https://orcid.org/0000-0003-1009-877X"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jogeshwar Mukherjee","raw_affiliation_strings":["Preclinical Imaging, Department of Radiological Sciences, University of California Irvine, California 92697, USA ; Cancer Center and Research Institute, University of California Irvine, California 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Imaging, Department of Radiological Sciences, University of California Irvine, California 92697, USA ; Cancer Center and Research Institute, University of California Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":null,"apc_paid":null,"fwci":0.7711,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.65835647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"4","issue":"4","first_page":"324","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.7182999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.7182999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.1281999945640564,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.08330000191926956,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7789999842643738},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/a-j-mice","display_name":"A/J mice","score":0.8159999847412109},{"id":"https://openalex.org/keywords/pet-ct","display_name":"PET/CT","score":0.8799999952316284},{"id":"https://openalex.org/keywords/radiosynthesis","display_name":"radiotracer synthesis","score":0.843999981880188},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.800000011920929},{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":0.8500000238418579},{"id":"https://openalex.org/keywords/pulmonary-nodules","display_name":"pulmonary nodules","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.858745813369751},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5441009998321533},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5279794335365295},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5006387233734131},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4646185636520386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2345612347126007}],"mesh":[],"locations_count":4,"locations":[{"id":"pmid:24982818","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24982818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of nuclear medicine and molecular imaging","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4074498","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4074498/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Nucl Med Mol Imaging","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8k0810gr","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/8k0810gr","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American journal of nuclear medicine and molecular imaging, vol 4, iss 4","raw_type":"article"},{"id":"mag:245217128","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24982818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4074498","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4074498/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Nucl Med Mol Imaging","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2441501596","display_name":"PET Imaging Agents for a4b2 Nicotinic Receptors","funder_award_id":"R01AG029479","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5154744214","display_name":"Nicotinic Receptor Ligands and Tobacco-induced Lung Cancer","funder_award_id":"R01ES017009","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6664103498","display_name":"Small Animal MicroCT","funder_award_id":"S10RR024546","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G734119170","display_name":"Small Animal PET (microPET)","funder_award_id":"S10RR019269","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8432661809","display_name":"PET Imaging agents for a4b2 Nicotinic Receptors","funder_award_id":"RF1AG029479","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W35527855","https://openalex.org/W140287985","https://openalex.org/W1955756746","https://openalex.org/W1964473274","https://openalex.org/W1972100007","https://openalex.org/W1976447570","https://openalex.org/W1977004529","https://openalex.org/W1979743501","https://openalex.org/W1982555880","https://openalex.org/W1988030523","https://openalex.org/W1991660464","https://openalex.org/W2000685180","https://openalex.org/W2029148944","https://openalex.org/W2044943027","https://openalex.org/W2064801613","https://openalex.org/W2065437875","https://openalex.org/W2091304009","https://openalex.org/W2102650381","https://openalex.org/W2115593774","https://openalex.org/W2118416526","https://openalex.org/W2164713773","https://openalex.org/W2334867674"],"related_works":["https://openalex.org/W2135565304","https://openalex.org/W1004468826","https://openalex.org/W2314360077","https://openalex.org/W3151024962","https://openalex.org/W2792015766","https://openalex.org/W2280959624","https://openalex.org/W2334867674","https://openalex.org/W836642015","https://openalex.org/W1972100007","https://openalex.org/W2497569838"],"abstract_inverted_index":{"Elevated":[0],"levels":[1],"of":[2,12,33,42,49,63,111,132,147,151,168,177,187,190,224],"histone":[3],"deacetylases":[4],"(HDACs)":[5],"have":[6],"been":[7,17],"indicated":[8],"in":[9,38,60,98,135,155,165,200,228,231],"the":[10,39,116,156,166,178,201,222,232],"development":[11],"some":[13],"cancers.":[14],"HDAC":[15,118],"has":[16],"imaged":[18],"using":[19,45,103],"(18)F-FAHA":[20,34,46,55,94,112,152,162,199,218],"and":[21,95,108,181,196],"may":[22,220],"serve":[23],"as":[24,35],"a":[25,36],"marker":[26],"to":[27,137],"study":[28,223],"epigenetics.":[29],"We":[30],"report":[31],"evaluation":[32],"probe":[37],"early":[40],"diagnosis":[41],"lung":[43,133,191,214],"cancer":[44,215],"PET/CT":[47,100],"studies":[48,210],"A/J":[50,66,212],"mice":[51,67,141,144,158,170,183,203,213],"treated":[52],"with":[53,79,123,171,204,211],"NNK.":[54],"radiosynthesis":[56],"was":[57,113,153],"carried":[58],"out":[59],"specific":[61],"activity":[62,127],"~2":[64],"Ci/\u03bcmol.":[65],"were":[68,89,145],"divided":[69],"into":[70],"2":[71],"groups:":[72],"1.":[73],"Controls;":[74],"2.":[75],"NNK":[76,80,140,180,202],"treatment":[77],"group":[78],"(100":[81],"mg/kg,":[82],"ip,":[83],"weekly":[84],"for":[85],"4":[86],"wks).":[87],"Mice":[88],"injected":[90],"100-200":[91],"\u03bcCi":[92],"i.v.":[93],"then":[96],"scanned":[97],"Inveon":[99],"under":[101],"anesthesia":[102],"2.0%":[104],"isoflurane.":[105],"Midbrain,":[106],"cerebellum":[107],"brainstem":[109],"uptake":[110,150,163],"displaced":[114],"by":[115,194,198],"known":[117],"inhibitor,":[119],"suberanilohydroxamic":[120],"acid":[121],"(SAHA)":[122],"less":[124],"than":[125],"10%":[126],"remaining.":[128],"CT":[129,195],"revealed":[130],"presence":[131,186],"nodules":[134,192],"8":[136],"10-month":[138],"old":[139],"while":[142,160],"control":[143,157,182],"free":[146],"tumors.":[148],"Little":[149],"observed":[154],"lungs":[159,167,184],"significant":[161],"occurred":[164],"NNK-treated":[169],"tumor/nontumor":[172,205],">2.0.":[173],"Ex":[174],"vivo":[175],"scans":[176],"excised":[179],"confirmed":[185,197],"extensive":[188],"amounts":[189],"seen":[193],">6.0.":[206],"Our":[207],"preliminary":[208],"imaging":[209],"model":[216],"suggest":[217],"PET":[219],"allow":[221],"epigenetic":[225],"mechanisms":[226],"involved":[227],"NNK-induced":[229],"tumorigenesis":[230],"lungs.":[233]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}