{"id":"https://openalex.org/W2444196643","doi":null,"title":"Sorting of CD4 and the SIV envelope glycoprotein in the endocytic pathway","display_name":"Sorting of CD4 and the SIV envelope glycoprotein in the endocytic pathway","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2444196643","mag":"2444196643"},"language":"en","primary_location":{"id":"pmh:hdl:10068/612817","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/612817","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087632400","display_name":"Katherine Bowers","orcid":"https://orcid.org/0000-0001-5085-5208","observed_orcids":["https://orcid.org/0000-0001-5085-5208"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Katherine Bowers","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5085-5208","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5087632400"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd4","display_name":"CD4","score":0.9639999866485596},{"id":"https://openalex.org/keywords/clathrin-mediated-endocytosis","display_name":"clathrin-mediated endocytosis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tyrosine-based-sorting-signal","display_name":"tyrosine-based sorting signal","score":0.8199999928474426},{"id":"https://openalex.org/keywords/ap2-adaptor-complex","display_name":"AP2 adaptor complex","score":0.8830000162124634},{"id":"https://openalex.org/keywords/endosomal-sorting","display_name":"endosomal sorting","score":0.652999997138977},{"id":"https://openalex.org/keywords/membrane-recycling","display_name":"membrane recycling","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.8189677000045776},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.79099440574646},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.7731307744979858},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6515111923217773},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5749413967132568},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.5550529956817627},{"id":"https://openalex.org/C63162447","wikidata":"https://www.wikidata.org/wiki/Q21100804","display_name":"Clathrin","level":4,"score":0.5398058891296387},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.4303596317768097},{"id":"https://openalex.org/C559089031","wikidata":"https://www.wikidata.org/wiki/Q658882","display_name":"Protein targeting","level":4,"score":0.423566073179245},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.25425463914871216},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.19540449976921082},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1394226849079132},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12625080347061157},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.07206439971923828},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:hdl:10068/612817","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/612817","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10099810","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10099810/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:2444196643","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/286733","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2010342138","https://openalex.org/W2079232939","https://openalex.org/W2058032164","https://openalex.org/W7100742099","https://openalex.org/W2005476021","https://openalex.org/W2163519490","https://openalex.org/W3140140981","https://openalex.org/W2034988569","https://openalex.org/W4283023969","https://openalex.org/W2009205890"],"abstract_inverted_index":{"Two":[0],"main":[1],"classes":[2],"of":[3,19,21,33,60,69,82,94,132,216,236],"molecular":[4],"signals":[5,23,88,114],"for":[6,105],"clathrin-mediated":[7],"endocytosis":[8,85,93,101,113],"have":[9,28,48,74,184,197],"been":[10,186],"identified:":[11],"tyrosine-based":[12,38,53],"and":[13,40,77,108,111,160,263],"dileucine-based.":[14],"To":[15],"understand":[16],"the":[17,30,51,57,61,79,130,137,144,170,208,214,222],"modes":[18],"action":[20],"these":[22],"in":[24,56,89,188,207,218,258],"more":[25,98],"detail,":[26],"I":[27,47,73,125,196],"analysed":[29],"envelope":[31,63],"protein":[32,65,189,210,226],"SIV,":[34],"which":[35,42],"contains":[36,43],"a":[37,44,70,199,203,254,270],"signal,":[39,102],"CD4,":[41],"dileucine-based":[45,112],"signal.":[46],"determined":[49],"that":[50,157],"membrane-proximal":[52],"internalisation":[54],"signal":[55,86],"cytoplasmic":[58],"domain":[59],"SIV":[62],"transmembrane":[64],"(SIV-TM)":[66],"is":[67,233],"part":[68],"YXX0":[71],"motif.":[72],"also":[75,242],"identified":[76],"mapped":[78],"approximate":[80],"location":[81],"an":[83,244,259,265],"additional":[84],"or":[87,134,143],"SIV-TM.":[90],"The":[91,247],"efficient":[92],"SIV-TM,":[95],"mediated":[96],"by":[97,119],"than":[99],"one":[100],"has":[103],"implications":[104],"viral":[106],"assembly":[107],"pathogenesis.":[109],"Tyrosine-":[110],"are":[115,177],"thought":[116],"to":[117,128,136,167,193,212,230,240,252,268],"function":[118],"interaction":[120],"with":[121,202],"clathrin-associated":[122],"adaptor":[123,139],"complexes.":[124],"was":[126],"unable":[127],"demonstrate":[129],"binding":[131],"CD4":[133,159,176,219],"SIV-TM":[135,161],"AP2":[138],"using":[140,152],"co-immunoprecipitation":[141],"techniques":[142],"yeast":[145],"2":[146],"hybrid":[147],"system.":[148],"However,":[149],"preliminary":[150],"experiments":[151],"surface":[153],"plasmon":[154],"resonance":[155],"suggest":[156],"both":[158],"do":[162],"bind":[163],"AP2.":[164],"In":[165,221],"addition":[166],"sorting":[168],"at":[169],"plasma":[171],"membrane,":[172],"molecules":[173],"such":[174],"as":[175],"sorted":[178],"within":[179],"endosomes.":[180,195],"COPI":[181,209],"coat":[182],"proteins":[183],"recently":[185],"implicated":[187],"transport":[190,227],"from":[191,228],"early":[192,229,260],"late":[194,231],"used":[198],"cell":[200],"line":[201],"temperature":[204],"sensitive":[205],"mutation":[206],"eCOP,":[211],"investigate":[213],"role":[215],"eCOP":[217,223,237],"sorting.":[220],"mutant":[224,238,248],"cells,":[225],"endosomes":[232],"inhibited.":[234],"Exposure":[235],"cells":[239,249],"stress":[241],"causes":[243],"interesting":[245],"phenotype.":[246],"appear":[250],"able":[251],"accumulate":[253],"fluid":[255],"phase":[256],"marker":[257],"endosome":[261],"compartment,":[262],"show":[264],"apparent":[266],"inability":[267],"recycle":[269],"bulk":[271],"membrane":[272],"marker.":[273]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}