{"id":"https://openalex.org/W2443250653","doi":null,"title":"Transmigration of breast cancer and melanoma cells through the blood-brain barrier: similarities and differences","display_name":"Transmigration of breast cancer and melanoma cells through the blood-brain barrier: similarities and differences","publication_year":2016,"publication_date":"2016-05-17","ids":{"openalex":"https://openalex.org/W2443250653","mag":"2443250653"},"language":"en","primary_location":{"id":"mag:2443250653","doi":null,"is_oa":false,"landing_page_url":"http://doktori.bibl.u-szeged.hu/id/eprint/2967","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100879927","display_name":"Judit Moln\u00e1r","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Judit Moln\u00e1r","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100879927"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05780875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.8619999885559082},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9419999718666077},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.921999990940094},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9269999861717224},{"id":"https://openalex.org/keywords/rac","display_name":"Rac","score":0.6480000019073486},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9589999914169312},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":0.9900000095367432},{"id":"https://openalex.org/keywords/brain-endothelium","display_name":"brain endothelium","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.763461172580719},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6492700576782227},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5627155900001526},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5604246258735657},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.5535436868667603},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5457288026809692},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4747210741043091},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.47467947006225586},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4526781737804413},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.43053942918777466},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3573780655860901},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3390696048736572},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28662416338920593},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2548139691352844},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1737789511680603},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1685098111629486},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.13310402631759644}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2443250653","doi":null,"is_oa":false,"landing_page_url":"http://doktori.bibl.u-szeged.hu/id/eprint/2967","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":114,"referenced_works":["https://openalex.org/W76264893","https://openalex.org/W1258373536","https://openalex.org/W1486460534","https://openalex.org/W1574220082","https://openalex.org/W1967871589","https://openalex.org/W1968783143","https://openalex.org/W1969082125","https://openalex.org/W1970897882","https://openalex.org/W1974167629","https://openalex.org/W1974473991","https://openalex.org/W1975073476","https://openalex.org/W1975585680","https://openalex.org/W1977055669","https://openalex.org/W1979629373","https://openalex.org/W1981425827","https://openalex.org/W1981672008","https://openalex.org/W1981673516","https://openalex.org/W1985053217","https://openalex.org/W1985649889","https://openalex.org/W1989893172","https://openalex.org/W1990985572","https://openalex.org/W1995010096","https://openalex.org/W1995045473","https://openalex.org/W1995707319","https://openalex.org/W1999476814","https://openalex.org/W2002034430","https://openalex.org/W2002203108","https://openalex.org/W2006486528","https://openalex.org/W2006741643","https://openalex.org/W2007708721","https://openalex.org/W2007772480","https://openalex.org/W2011583083","https://openalex.org/W2012111901","https://openalex.org/W2012890562","https://openalex.org/W2015541518","https://openalex.org/W2016884409","https://openalex.org/W2021827571","https://openalex.org/W2024103532","https://openalex.org/W2028399621","https://openalex.org/W2030154807","https://openalex.org/W2031134972","https://openalex.org/W2033828724","https://openalex.org/W2036544564","https://openalex.org/W2038444072","https://openalex.org/W2039793441","https://openalex.org/W2040536713","https://openalex.org/W2040828315","https://openalex.org/W2041212534","https://openalex.org/W2042264070","https://openalex.org/W2043166238","https://openalex.org/W2046012377","https://openalex.org/W2047074480","https://openalex.org/W2049715526","https://openalex.org/W2051600139","https://openalex.org/W2051696217","https://openalex.org/W2052912902","https://openalex.org/W2054902434","https://openalex.org/W2056298786","https://openalex.org/W2056856515","https://openalex.org/W2058689904","https://openalex.org/W2060205349","https://openalex.org/W2062182733","https://openalex.org/W2064841852","https://openalex.org/W2065165331","https://openalex.org/W2067114155","https://openalex.org/W2068430088","https://openalex.org/W2068900347","https://openalex.org/W2072278357","https://openalex.org/W2077080652","https://openalex.org/W2079316414","https://openalex.org/W2079482620","https://openalex.org/W2083543572","https://openalex.org/W2087666006","https://openalex.org/W2088999149","https://openalex.org/W2092586750","https://openalex.org/W2094094393","https://openalex.org/W2096027508","https://openalex.org/W2096661713","https://openalex.org/W2100308259","https://openalex.org/W2102978104","https://openalex.org/W2103831817","https://openalex.org/W2104290477","https://openalex.org/W2104567497","https://openalex.org/W2107325549","https://openalex.org/W2111807830","https://openalex.org/W2111957505","https://openalex.org/W2114021514","https://openalex.org/W2115515762","https://openalex.org/W2115924220","https://openalex.org/W2118705802","https://openalex.org/W2125640458","https://openalex.org/W2129926378","https://openalex.org/W2132400614","https://openalex.org/W2133314802","https://openalex.org/W2138388493","https://openalex.org/W2148992136","https://openalex.org/W2149037769","https://openalex.org/W2153499980","https://openalex.org/W2155579605","https://openalex.org/W2157179314","https://openalex.org/W2158926036","https://openalex.org/W2159042484","https://openalex.org/W2159821105","https://openalex.org/W2159897971","https://openalex.org/W2160867041","https://openalex.org/W2163788379","https://openalex.org/W2165512112","https://openalex.org/W2167809990","https://openalex.org/W2167920040","https://openalex.org/W2171902538","https://openalex.org/W2178539375","https://openalex.org/W2375169070","https://openalex.org/W2476375029","https://openalex.org/W3116349506"],"related_works":["https://openalex.org/W4256670280","https://openalex.org/W2198185918","https://openalex.org/W7096338688","https://openalex.org/W2913325570","https://openalex.org/W1985649889","https://openalex.org/W7099467250","https://openalex.org/W3089479299","https://openalex.org/W1783602318","https://openalex.org/W7099538341","https://openalex.org/W1990402801"],"abstract_inverted_index":{"Brain":[0],"metastases":[1,17,190],"are":[2,18],"common":[3],"and":[4,11,37,68,111,135,193],"devastating":[5],"complications":[6],"of":[7,92,101,107,121,129,131,139,141,156,188,191],"both":[8],"breast":[9,58,78,108,132,194],"cancer":[10,59,79,109,133],"melanoma.":[12],"Although":[13],"mammary":[14],"carcinoma":[15],"brain":[16,53,74,116,158,189],"more":[19,66],"frequent":[20],"than":[21,77],"those":[22],"originating":[23],"from":[24],"melanoma,":[25],"this":[26],"latter":[27],"has":[28,165],"the":[29,33,52,115,126,136,145,148,153,157,161,176,186],"highest":[30],"tropism":[31],"to":[32,51,57,88,114],"brain.":[34],"Using":[35],"static":[36],"dynamic":[38],"in":[39,55,69,184],"vitro":[40],"approaches,":[41],"here":[42],"we":[43],"show":[44,98],"that":[45,99,174],"melanoma":[46,62,83,112,142,192],"cells":[47,63,84,110,113,134],"have":[48,85],"increased":[49,86],"adhesion":[50,106],"endothelium":[54],"comparison":[56],"cells.":[60,80,95,143],"Moreover,":[61],"can":[64],"transmigrate":[65],"rapidly":[67],"a":[70,181],"higher":[71],"number":[72],"through":[73],"endothelial":[75,94],"monolayers":[76],"In":[81,118],"addition,":[82,119],"ability":[87],"impair":[89],"tight":[90],"junctions":[91],"cerebral":[93],"We":[96,172],"also":[97],"inhibition":[100,120],"Rac":[102,122,149],"or":[103,123],"PI3K":[104,124,162],"impedes":[105],"endothelium.":[117],"inhibits":[125],"late":[127],"phase":[128,138],"transmigration":[130,140],"early":[137],"On":[144],"other":[146],"hand,":[147],"inhibitor":[150,163],"EHT1864":[151],"impairs":[152],"junctional":[154],"integrity":[155],"endothelium,":[159],"while":[160],"LY294002":[164],"no":[166],"damaging":[167],"effect":[168],"on":[169],"interendothelial":[170],"junctions.":[171],"suggest":[173],"targeting":[175],"PI3K/Akt":[177],"pathway":[178],"may":[179],"represent":[180],"novel":[182],"opportunity":[183],"preventing":[185],"formation":[187],"cancer.":[195]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}