{"id":"https://openalex.org/W2443085751","doi":"https://doi.org/10.1038/mto.2016.15","title":"Clinical manufacturing of CAR T cells: foundation of a promising therapy","display_name":"Clinical manufacturing of CAR T cells: foundation of a promising therapy","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2443085751","doi":"https://doi.org/10.1038/mto.2016.15","mag":"2443085751","pmid":"https://pubmed.ncbi.nlm.nih.gov/27347557"},"language":"en","primary_location":{"id":"doi:10.1038/mto.2016.15","doi":"https://doi.org/10.1038/mto.2016.15","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mto.2016.15","pdf_url":"http://www.cell.com/article/S2372770516300390/pdf","source":{"id":"https://openalex.org/S2898235705","display_name":"Molecular Therapy \u2014 Oncolytics","issn_l":"2372-7705","issn":["2372-7705"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Oncolytics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2372770516300390/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101691045","display_name":"Xiuyan Wang","orcid":"https://orcid.org/0000-0002-1551-3330","observed_orcids":["https://orcid.org/0000-0002-1551-3330"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiuyan Wang","raw_affiliation_strings":["Cell Therapy and Cell Engineering Facility, Memorial Sloan-Kettering Cancer Center, New York, New York, USA; Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center, New York, New York, USA; Molecular Pharmacology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","Cell Therapy and Cell Engineering Facility, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","Molecular Pharmacology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Therapy and Cell Engineering Facility, Memorial Sloan-Kettering Cancer Center, New York, New York, USA; Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center, New York, New York, USA; Molecular Pharmacology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Cell Therapy and Cell Engineering Facility, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Molecular Pharmacology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036831073","display_name":"Isabelle Rivi\u00e8re","orcid":"https://orcid.org/0000-0002-7363-3963","observed_orcids":["https://orcid.org/0000-0002-7363-3963"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Isabelle Rivi\u00e8re","raw_affiliation_strings":["Cell Therapy and Cell Engineering Facility, Memorial Sloan-Kettering Cancer Center, New York, New York, USA; Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center, New York, New York, USA; Molecular Pharmacology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","Cell Therapy and Cell Engineering Facility, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","Molecular Pharmacology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Therapy and Cell Engineering Facility, Memorial Sloan-Kettering Cancer Center, New York, New York, USA; Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center, New York, New York, USA; Molecular Pharmacology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Cell Therapy and Cell Engineering Facility, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Molecular Pharmacology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036831073"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":19.9271,"has_fulltext":false,"cited_by_count":636,"citation_normalized_percentile":{"value":0.9956322,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"3","issue":null,"first_page":"16015","last_page":"16015"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.8659999966621399},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"chimeric antigen receptor","score":0.8320000171661377},{"id":"https://openalex.org/keywords/production-standardization","display_name":"production standardization","score":0.6779999732971191},{"id":"https://openalex.org/keywords/product-quality","display_name":"product quality","score":0.6809999942779541},{"id":"https://openalex.org/keywords/product-characterization","display_name":"product characterization","score":0.8880000114440918},{"id":"https://openalex.org/keywords/manufacturing-platforms","display_name":"manufacturing platforms","score":0.6940000057220459},{"id":"https://openalex.org/keywords/adoptive-cellular-therapy","display_name":"adoptive cellular therapy","score":0.7519999742507935},{"id":"https://openalex.org/keywords/autologous-t-cells","display_name":"autologous T cells","score":0.7829999923706055},{"id":"https://openalex.org/keywords/commercialization","display_name":"commercialization","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.7571266889572144},{"id":"https://openalex.org/C2780625559","wikidata":"https://www.wikidata.org/wiki/Q5152592","display_name":"Commercialization","level":2,"score":0.7296134233474731},{"id":"https://openalex.org/C188087704","wikidata":"https://www.wikidata.org/wiki/Q369577","display_name":"Standardization","level":2,"score":0.7183812260627747},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.48852860927581787},{"id":"https://openalex.org/C2779709869","wikidata":"https://www.wikidata.org/wiki/Q1292017","display_name":"Good manufacturing practice","level":3,"score":0.4786873459815979},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.450679749250412},{"id":"https://openalex.org/C117671659","wikidata":"https://www.wikidata.org/wiki/Q11049265","display_name":"Manufacturing engineering","level":1,"score":0.4310700297355652},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40709951519966125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.339143306016922},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.31039953231811523},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3077036738395691},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.22836634516716003},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.22551986575126648},{"id":"https://openalex.org/C108713360","wikidata":"https://www.wikidata.org/wiki/Q1824206","display_name":"Supply chain","level":2,"score":0.09417298436164856},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.08026817440986633},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/mto.2016.15","doi":"https://doi.org/10.1038/mto.2016.15","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mto.2016.15","pdf_url":"http://www.cell.com/article/S2372770516300390/pdf","source":{"id":"https://openalex.org/S2898235705","display_name":"Molecular Therapy \u2014 Oncolytics","issn_l":"2372-7705","issn":["2372-7705"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Oncolytics","raw_type":"journal-article"},{"id":"pmid:27347557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27347557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy oncolytics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4909095","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4909095","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mol Ther Oncolytics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5311327946444c02a2cb7b3e9317382a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5311327946444c02a2cb7b3e9317382a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Therapy: Oncolytics, Vol 3, Iss C (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/mto.2016.15","doi":"https://doi.org/10.1038/mto.2016.15","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mto.2016.15","pdf_url":"http://www.cell.com/article/S2372770516300390/pdf","source":{"id":"https://openalex.org/S2898235705","display_name":"Molecular Therapy \u2014 Oncolytics","issn_l":"2372-7705","issn":["2372-7705"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Oncolytics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6759421960","display_name":"MSKCC Center for Molecular Imaging in Cancer","funder_award_id":"P50CA086438","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320311534","display_name":"Starr Foundation","ror":"https://ror.org/00gqt9c14"},{"id":"https://openalex.org/F4320333670","display_name":"Juno Therapeutics","ror":"https://ror.org/02dq5dx40"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2443085751.pdf"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1750089824","https://openalex.org/W1839053269","https://openalex.org/W1908249423","https://openalex.org/W1964809183","https://openalex.org/W1970943602","https://openalex.org/W1971518635","https://openalex.org/W1975962380","https://openalex.org/W1981464141","https://openalex.org/W1983056774","https://openalex.org/W1984716051","https://openalex.org/W1989273697","https://openalex.org/W1996092614","https://openalex.org/W2000084158","https://openalex.org/W2004131048","https://openalex.org/W2009761723","https://openalex.org/W2012108097","https://openalex.org/W2017718094","https://openalex.org/W2017786183","https://openalex.org/W2021032653","https://openalex.org/W2021122662","https://openalex.org/W2024746352","https://openalex.org/W2033149742","https://openalex.org/W2033952412","https://openalex.org/W2047192675","https://openalex.org/W2051549641","https://openalex.org/W2052011668","https://openalex.org/W2055820960","https://openalex.org/W2058817033","https://openalex.org/W2061499228","https://openalex.org/W2066186103","https://openalex.org/W2077285487","https://openalex.org/W2079766756","https://openalex.org/W2085060041","https://openalex.org/W2085645098","https://openalex.org/W2087209798","https://openalex.org/W2093168673","https://openalex.org/W2099570622","https://openalex.org/W2101107810","https://openalex.org/W2101535233","https://openalex.org/W2105400883","https://openalex.org/W2108131113","https://openalex.org/W2110903678","https://openalex.org/W2122465970","https://openalex.org/W2124513722","https://openalex.org/W2129702476","https://openalex.org/W2129827880","https://openalex.org/W2130011407","https://openalex.org/W2130338247","https://openalex.org/W2130830673","https://openalex.org/W2132042881","https://openalex.org/W2133298966","https://openalex.org/W2144796561","https://openalex.org/W2150630962","https://openalex.org/W2153520524","https://openalex.org/W2155825917","https://openalex.org/W2163766654","https://openalex.org/W2170513194","https://openalex.org/W2170792469","https://openalex.org/W2171082742","https://openalex.org/W2207721475","https://openalex.org/W2219506342","https://openalex.org/W2265134611","https://openalex.org/W2323522715","https://openalex.org/W2331395663","https://openalex.org/W2497706524","https://openalex.org/W2555135979","https://openalex.org/W3004335124","https://openalex.org/W6687982370"],"related_works":["https://openalex.org/W4386136016","https://openalex.org/W4207047620","https://openalex.org/W2590904087","https://openalex.org/W2064673031","https://openalex.org/W2221356301","https://openalex.org/W4391185405","https://openalex.org/W4234093800","https://openalex.org/W3187081175","https://openalex.org/W2976192453","https://openalex.org/W4248078591"],"abstract_inverted_index":{"The":[0],"treatment":[1],"of":[2,17,27,40,52,71,85,88,118],"cancer":[3],"patients":[4],"with":[5],"autologous":[6],"T":[7],"cells":[8],"expressing":[9],"a":[10,34,91],"chimeric":[11],"antigen":[12],"receptor":[13],"(CAR)":[14],"is":[15,33],"one":[16],"the":[18,37,53,59,69,72,83],"most":[19],"promising":[20],"adoptive":[21],"cellular":[22],"therapy":[23,79],"approaches.":[24],"Reproducible":[25],"manufacturing":[26,54,74,100],"high-quality,":[28],"clinical-grade":[29],"CAR-T":[30,77],"cell":[31,78],"products":[32],"prerequisite":[35],"for":[36,90],"wide":[38],"application":[39],"this":[41,119],"technology.":[42],"Product":[43],"quality":[44],"needs":[45],"to":[46,63,99,106,111],"be":[47,64,81,107],"built-in":[48],"within":[49],"every":[50],"step":[51],"process.":[55],"We":[56],"summarize":[57],"herein":[58],"requirements":[60],"and":[61,102,115],"logistics":[62],"considered,":[65],"as":[66,68],"well":[67],"state":[70],"art":[73],"platforms":[75],"available.":[76],"may":[80],"on":[82],"verge":[84],"becoming":[86],"standard":[87],"care":[89],"few":[92],"clinical":[93],"indications.":[94],"Yet,":[95],"many":[96],"challenges":[97],"pertaining":[98],"standardization":[101],"product":[103],"characterization":[104],"remain":[105],"overcome":[108],"in":[109],"order":[110],"achieve":[112],"broad":[113],"usage":[114],"eventual":[116],"commercialization":[117],"therapeutic":[120],"modality.":[121]},"counts_by_year":[{"year":2026,"cited_by_count":58},{"year":2025,"cited_by_count":47},{"year":2024,"cited_by_count":71},{"year":2023,"cited_by_count":64},{"year":2022,"cited_by_count":77},{"year":2021,"cited_by_count":102},{"year":2020,"cited_by_count":87},{"year":2019,"cited_by_count":54},{"year":2018,"cited_by_count":41},{"year":2017,"cited_by_count":28},{"year":2016,"cited_by_count":6},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-22T09:42:04.148104","created_date":"2025-10-10T00:00:00"}