{"id":"https://openalex.org/W2443052573","doi":"https://doi.org/10.1080/00365521.1976.12097076","title":"Effect of Bilateral Nephrectomy on Serum Gastrin Concentration, Gastric Histamine Content, Histidine Decarboxylase Activity, and Acid Secretion in the Rat","display_name":"Effect of Bilateral Nephrectomy on Serum Gastrin Concentration, Gastric Histamine Content, Histidine Decarboxylase Activity, and Acid Secretion in the Rat","publication_year":1976,"publication_date":"1976-01-01","ids":{"openalex":"https://openalex.org/W2443052573","doi":"https://doi.org/10.1080/00365521.1976.12097076","mag":"2443052573","pmid":"https://pubmed.ncbi.nlm.nih.gov/56028"},"language":"en","primary_location":{"id":"doi:10.1080/00365521.1976.12097076","doi":"https://doi.org/10.1080/00365521.1976.12097076","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00365521.1976.12097076","pdf_url":null,"source":{"id":"https://openalex.org/S55592950","display_name":"Scandinavian Journal of Gastroenterology","issn_l":"0036-5521","issn":["0036-5521","1502-7708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111811913","display_name":"H. A. El Munshid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I2801941904","display_name":"Bispebjerg Hospital","ror":"https://ror.org/00td68a17","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801941904","https://openalex.org/I2802567020"]}],"countries":["DK","SE"],"is_corresponding":false,"raw_author_name":"H. A. El Munshid","raw_affiliation_strings":["Depts. of Pharmacology, Surgery and Histology, University of Lund, Lund, Sweden, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depts. of Pharmacology, Surgery and Histology, University of Lund, Lund, Sweden, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I2801941904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079591721","display_name":"G Liedberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I2801941904","display_name":"Bispebjerg Hospital","ror":"https://ror.org/00td68a17","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801941904","https://openalex.org/I2802567020"]}],"countries":["DK","SE"],"is_corresponding":false,"raw_author_name":"G. Liedberg","raw_affiliation_strings":["Depts. of Pharmacology, Surgery and Histology, University of Lund, Lund, Sweden, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depts. of Pharmacology, Surgery and Histology, University of Lund, Lund, Sweden, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I2801941904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072702049","display_name":"J. F. Rehfeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I2801941904","display_name":"Bispebjerg Hospital","ror":"https://ror.org/00td68a17","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801941904","https://openalex.org/I2802567020"]}],"countries":["DK","SE"],"is_corresponding":false,"raw_author_name":"J. F. Rehfeld","raw_affiliation_strings":["Depts. of Pharmacology, Surgery and Histology, University of Lund, Lund, Sweden, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depts. of Pharmacology, Surgery and Histology, University of Lund, Lund, Sweden, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I2801941904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014848806","display_name":"F. Sundler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I2801941904","display_name":"Bispebjerg Hospital","ror":"https://ror.org/00td68a17","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801941904","https://openalex.org/I2802567020"]}],"countries":["DK","SE"],"is_corresponding":false,"raw_author_name":"F. Sundler","raw_affiliation_strings":["Depts. of Pharmacology, Surgery and Histology, University of Lund, Lund, Sweden, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depts. of Pharmacology, Surgery and Histology, University of Lund, Lund, Sweden, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I2801941904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041107223","display_name":"Lars Larsson","orcid":"https://orcid.org/0000-0002-6440-1458","observed_orcids":["https://orcid.org/0000-0002-6440-1458"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I2801941904","display_name":"Bispebjerg Hospital","ror":"https://ror.org/00td68a17","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801941904","https://openalex.org/I2802567020"]}],"countries":["DK","SE"],"is_corresponding":false,"raw_author_name":"L.-I. Larsson","raw_affiliation_strings":["Depts. of Pharmacology, Surgery and Histology, University of Lund, Lund, Sweden, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depts. of Pharmacology, Surgery and Histology, University of Lund, Lund, Sweden, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I2801941904"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111673085","display_name":"Rolf H\u00e5kanson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I2801941904","display_name":"Bispebjerg Hospital","ror":"https://ror.org/00td68a17","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801941904","https://openalex.org/I2802567020"]}],"countries":["DK","SE"],"is_corresponding":false,"raw_author_name":"R. H\u00e5kanson","raw_affiliation_strings":["Depts. of Pharmacology, Surgery and Histology, University of Lund, Lund, Sweden, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depts. of Pharmacology, Surgery and Histology, University of Lund, Lund, Sweden, and Dept. of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I2801941904"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8353,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.70496677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"1","first_page":"87","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.31690001487731934,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.31690001487731934,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.1647000014781952,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.1388999968767166,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bilateral-nephrectomy","display_name":"bilateral nephrectomy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/serum-gastrin","display_name":"serum gastrin","score":0.8360000252723694},{"id":"https://openalex.org/keywords/gastric-acid-secretion","display_name":"gastric acid secretion","score":0.8169999718666077},{"id":"https://openalex.org/keywords/gastric-histamine","display_name":"gastric histamine","score":0.9070000052452087},{"id":"https://openalex.org/keywords/histidine-decarboxylase","display_name":"histidine decarboxylase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pentagastrin","display_name":"pentagastrin","score":0.8040000200271606},{"id":"https://openalex.org/keywords/oxyntic-mucosa","display_name":"oxyntic mucosa","score":0.925000011920929},{"id":"https://openalex.org/keywords/histamine-stimulated-acid-secretion","display_name":"histamine-stimulated acid secretion","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C192233252","wikidata":"https://www.wikidata.org/wiki/Q421869","display_name":"Histidine decarboxylase","level":4,"score":0.9215909242630005},{"id":"https://openalex.org/C2776986829","wikidata":"https://www.wikidata.org/wiki/Q407181","display_name":"Gastrin","level":3,"score":0.888348400592804},{"id":"https://openalex.org/C2779377912","wikidata":"https://www.wikidata.org/wiki/Q423586","display_name":"Pentagastrin","level":4,"score":0.8184287548065186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8117968440055847},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.8019779324531555},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7994561195373535},{"id":"https://openalex.org/C2777504413","wikidata":"https://www.wikidata.org/wiki/Q846270","display_name":"Gastric acid","level":3,"score":0.7486711740493774},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5891767740249634},{"id":"https://openalex.org/C2780227381","wikidata":"https://www.wikidata.org/wiki/Q1357376","display_name":"Nephrectomy","level":3,"score":0.551735520362854},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4887351989746094},{"id":"https://openalex.org/C2781443798","wikidata":"https://www.wikidata.org/wiki/Q383249","display_name":"Gastric mucosa","level":3,"score":0.46025100350379944},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4356663227081299},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.38554635643959045},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.2946587800979614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2786988615989685},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19556602835655212},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1390276849269867}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002262","descriptor_name":"Carboxy-Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005750","descriptor_name":"Gastric Juice","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005755","descriptor_name":"Gastrins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006640","descriptor_name":"Histidine Decarboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009392","descriptor_name":"Nephrectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010418","descriptor_name":"Pentagastrin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/00365521.1976.12097076","doi":"https://doi.org/10.1080/00365521.1976.12097076","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00365521.1976.12097076","pdf_url":null,"source":{"id":"https://openalex.org/S55592950","display_name":"Scandinavian Journal of Gastroenterology","issn_l":"0036-5521","issn":["0036-5521","1502-7708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmid:56028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/56028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of gastroenterology","raw_type":"Journal Article"},{"id":"mag:2031669625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/56028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1970480405","https://openalex.org/W1999928128","https://openalex.org/W2002057953","https://openalex.org/W2058131993","https://openalex.org/W2066191870","https://openalex.org/W2073959471","https://openalex.org/W2084723943","https://openalex.org/W2091516171","https://openalex.org/W2109076327","https://openalex.org/W2130241523","https://openalex.org/W2326711131","https://openalex.org/W2410012516","https://openalex.org/W2411114516","https://openalex.org/W4301330540","https://openalex.org/W4302051390"],"related_works":["https://openalex.org/W2011949923","https://openalex.org/W2032135888","https://openalex.org/W2076510192","https://openalex.org/W1997244088","https://openalex.org/W4302051390","https://openalex.org/W2002057953","https://openalex.org/W1991057261","https://openalex.org/W1997520588","https://openalex.org/W2403696539","https://openalex.org/W2427476480"],"abstract_inverted_index":{"El":[0],"Munshid,":[1],"H.":[2],"A.,":[3],"Liedberg,":[4],"G.,":[5],"Rehfeld,":[6],"J.":[7,37],"F.,":[8,10],"Sundler,":[9],"Larsson,":[11],"L.-I.":[12],"&":[13],"H\u00e5kanson,":[14],"R.":[15],"Effect":[16],"of":[17,49,126,129,132],"bilateral":[18],"nephrectomy":[19,73],"on":[20],"serum":[21],"gastrin":[22,51,94,127],"concentration,":[23],"gastric":[24,68,109],"histamine":[25,64,75],"content,":[26],"histidine":[27,110],"decarboxylase":[28,79],"activity,":[29],"and":[30,65,122],"acid":[31,58,69,100,134],"secretion":[32,135],"in":[33,46,80,90],"the":[34,47,81,91,116],"rat.":[35],"Scand.":[36],"Gastroent.":[38],"1976,":[39],"11,":[40],"87-91.Nephrectomy":[41],"caused":[42],"a":[43],"marked":[44],"increase":[45,56],"concentration":[48],"circulating":[50],"immunoreactivity":[52],"but":[53,71,128],"did":[54],"not":[55,124],"basal":[57],"secretion.":[59],"In":[60],"normal":[61],"rats,":[62],"both":[63],"pentagastrin":[66],"stimulated":[67],"output,":[70],"after":[72],"only":[74,125],"was":[76,84],"effective.":[77],"Histidine":[78],"oxyntic":[82],"mucosa":[83],"greatly":[85],"activated":[86],"following":[87],"nephrectomy.":[88],"Thus,":[89],"nephrectomized":[92],"rat":[93],"(and":[95],"pentagastrin)":[96],"no":[97],"longer":[98],"evoked":[99],"secretion,":[101],"whereas":[102],"it":[103],"retained":[104],"its":[105],"ability":[106],"to":[107],"activate":[108],"decarboxylase.":[111],"The":[112],"results":[113],"suggest":[114],"that":[115],"kidney":[117],"is":[118],"important":[119],"for":[120],"metabolism":[121],"excretion":[123],"humoral":[130],"antagonists":[131],"gastrin-induced":[133],"as":[136],"well.":[137]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}