{"id":"https://openalex.org/W2442862586","doi":"https://doi.org/10.1158/1557-3125.rasonc14-ia09","title":"Abstract IA09: Copper is required for oncogenic BRAF signaling and tumorigenesis","display_name":"Abstract IA09: Copper is required for oncogenic BRAF signaling and tumorigenesis","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W2442862586","doi":"https://doi.org/10.1158/1557-3125.rasonc14-ia09","mag":"2442862586"},"language":"en","primary_location":{"id":"doi:10.1158/1557-3125.rasonc14-ia09","doi":"https://doi.org/10.1158/1557-3125.rasonc14-ia09","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3125.rasonc14-ia09","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046979544","display_name":"Donita C. Brady","orcid":"https://orcid.org/0000-0002-2786-2802","observed_orcids":["https://orcid.org/0000-0002-2786-2802"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donita Brady","raw_affiliation_strings":["1DUMC, Durham, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1DUMC, Durham, NC,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053521865","display_name":"Matt Crowe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matt Crowe","raw_affiliation_strings":["1DUMC, Durham, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1DUMC, Durham, NC,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042721180","display_name":"Michelle L. Turski","orcid":"https://orcid.org/0009-0007-2287-3637","observed_orcids":["https://orcid.org/0009-0007-2287-3637"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle Turski","raw_affiliation_strings":["1DUMC, Durham, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1DUMC, Durham, NC,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038184404","display_name":"Aaron Hobbs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Hobbs","raw_affiliation_strings":["2UNC at Chapel Hill, Chapel Hill, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2UNC at Chapel Hill, Chapel Hill, NC,","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050947319","display_name":"Xiao-Jie Yao","orcid":"https://orcid.org/0009-0000-0604-8206","observed_orcids":["https://orcid.org/0009-0000-0604-8206"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaojie Yao","raw_affiliation_strings":["1DUMC, Durham, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1DUMC, Durham, NC,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075097409","display_name":"A. Chaikuad","orcid":"https://orcid.org/0000-0003-1120-2209","observed_orcids":["https://orcid.org/0000-0003-1120-2209"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Apirat Chaikuad","raw_affiliation_strings":["3University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013336817","display_name":"Stefan Knapp","orcid":"https://orcid.org/0000-0001-5995-6494","observed_orcids":["https://orcid.org/0000-0001-5995-6494"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stefan Knapp","raw_affiliation_strings":["3University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103280382","display_name":"Kun\u2010Hong Xiao","orcid":"https://orcid.org/0000-0001-9424-5460","observed_orcids":["https://orcid.org/0000-0001-9424-5460"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kunhong Xiao","raw_affiliation_strings":["1DUMC, Durham, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1DUMC, Durham, NC,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sharon Campbell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon Campbell","raw_affiliation_strings":["2UNC at Chapel Hill, Chapel Hill, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2UNC at Chapel Hill, Chapel Hill, NC,","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062686245","display_name":"Dennis J. Thiele","orcid":"https://orcid.org/0000-0001-7549-0145","observed_orcids":["https://orcid.org/0000-0001-7549-0145"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennis Thiele","raw_affiliation_strings":["1DUMC, Durham, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1DUMC, Durham, NC,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087099776","display_name":"Christopher M. Counter","orcid":"https://orcid.org/0000-0003-0748-3079","observed_orcids":["https://orcid.org/0000-0003-0748-3079"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chris Counter","raw_affiliation_strings":["1DUMC, Durham, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1DUMC, Durham, NC,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"12_Supplement","first_page":"IA09","last_page":"IA09"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copper","display_name":"copper","score":0.9860000014305115},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/mek1","display_name":"MEK1","score":0.7250000238418579},{"id":"https://openalex.org/keywords/mek2","display_name":"MEK2","score":0.859000027179718},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9309999942779541},{"id":"https://openalex.org/keywords/copper-chelation-therapy","display_name":"copper chelation therapy","score":0.7710000276565552},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.5550000071525574},{"id":"https://openalex.org/keywords/braf-inhibitor-resistance","display_name":"BRAF inhibitor resistance","score":0.75},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.75},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.758069634437561},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7142885327339172},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6530670523643494},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5909497737884521},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5610358119010925},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5002632141113281},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44286802411079407},{"id":"https://openalex.org/C2776131300","wikidata":"https://www.wikidata.org/wiki/Q423111","display_name":"Vemurafenib","level":4,"score":0.42695915699005127},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3818703889846802},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37733182311058044},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1907360851764679},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13231274485588074},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.11782890558242798}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1557-3125.rasonc14-ia09","doi":"https://doi.org/10.1158/1557-3125.rasonc14-ia09","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3125.rasonc14-ia09","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2065687131","https://openalex.org/W2916655572","https://openalex.org/W4298021322","https://openalex.org/W3025050232","https://openalex.org/W2586911664","https://openalex.org/W2021978908","https://openalex.org/W2763277172","https://openalex.org/W2943955737","https://openalex.org/W2063084308","https://openalex.org/W2957907911"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"BRAF":[2,56,88,184,231],"serine/threonine":[3],"kinase":[4],"is":[5,82,227],"mutated,":[6],"typically":[7],"at":[8],"V600,":[9],"to":[10,27,49,78,86,183,197,248],"induce":[11],"an":[12,66,158],"active":[13],"oncogenic":[14,55,137,230],"state":[15],"in":[16,63,127,165],"a":[17,28,31,60,83,108,148],"large":[18],"fraction":[19],"of":[20,34,54,101,118,141,155,168,174,238],"melanoma,":[21,65],"thyroid,":[22],"hairy":[23],"cell":[24],"leukemia,":[25],"and":[26,42,57,105,136,233],"lesser":[29],"extent,":[30],"wide":[32],"spectrum":[33],"other":[35],"cancers.":[36,90,201],"BRAFV600E":[37,199],"activates":[38],"the":[39,46,119,166,239],"kinases":[40],"MEK1":[41,99,128],"MEK2,":[43],"which":[44],"stimulate":[45],"MAPK":[47,80,134],"pathway":[48],"promote":[50],"cancer.":[51],"ATP":[52],"inhibitors":[53],"MEK1/2":[58],"provide":[59],"survival":[61],"advantage":[62],"metastatic":[64],"effect":[67],"enhanced":[68],"by":[69,146],"co-administering":[70],"two":[71],"such":[72],"inhibitors.":[73],"Thus,":[74],"combining":[75],"multiple":[76],"approaches":[77],"inhibit":[79],"signaling":[81,135,232],"promising":[84],"strategy":[85],"treat":[87,198],"mutation-positive":[89,200],"We":[91,111],"previously":[92],"found":[93],"that":[94,115,129,151,191],"copper":[95],"(Cu)":[96],"influx":[97],"enhances":[98],"phosphorylation":[100],"its":[102],"substrates":[103],"ERK1":[104],"ERK2":[106],"through":[107],"Cu-MEK1":[109],"interaction.":[110],"now":[112],"show":[113],"here":[114],"genetic":[116],"loss":[117],"high":[120],"affinity":[121],"Cu":[122,131,156,162],"transporter":[123],"Ctr1":[124],"or":[125,157],"mutations":[126],"disrupt":[130],"binding":[132],"reduced":[133,171],"BRAFV600E-mediated":[138],"tumorigenesis.":[139,234],"Loss":[140],"tumor":[142,172],"growth":[143,173],"was":[144],"rescued":[145],"expressing":[147],"MEK1/5":[149],"chimera":[150],"phosphorylates":[152],"ERK1/2":[153],"independent":[154],"activated":[159],"ERK2.":[160],"Importantly,":[161],"chelators":[163],"used":[164],"treatment":[167],"Wilson":[169],"disease":[170],"not":[175],"only":[176],"BRAFV600E-transformed":[177],"cells,":[178],"but":[179],"also":[180],"cells":[181],"resistant":[182],"inhibition.":[185],"Taken":[186],"together,":[187],"these":[188],"results":[189],"suggest":[190],"Cu-chelation":[192],"therapy":[193],"could":[194],"be":[195],"repurposed":[196],"Citation":[202],"Format:":[203],"Donita":[204],"Brady,":[205],"Matt":[206],"Crowe,":[207],"Michelle":[208],"Turski,":[209],"Aaron":[210],"Hobbs,":[211],"Xiaojie":[212],"Yao,":[213],"Apirat":[214],"Chaikuad,":[215],"Stefan":[216],"Knapp,":[217],"Kunhong":[218],"Xiao,":[219],"Sharon":[220],"Campbell,":[221],"Dennis":[222],"Thiele,":[223],"Chris":[224],"Counter.":[225],"Copper":[226],"required":[228],"for":[229],"[abstract].":[235],"In:":[236],"Proceedings":[237],"AACR":[240],"Special":[241],"Conference":[242],"on":[243],"RAS":[244],"Oncogenes:":[245],"From":[246],"Biology":[247],"Therapy;":[249],"Feb":[250],"24-27,":[251],"2014;":[252],"Lake":[253],"Buena":[254],"Vista,":[255],"FL.":[256],"Philadelphia":[257],"(PA):":[258],"AACR;":[259],"Mol":[260],"Cancer":[261],"Res":[262],"2014;12(12":[263],"Suppl):Abstract":[264],"nr":[265],"IA09.":[266],"doi:":[267],"10.1158/1557-3125.RASONC14-IA09":[268]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
