{"id":"https://openalex.org/W2442494471","doi":"https://doi.org/10.20452/pamw.358","title":"Is there relationship between the A1166C polymorphism of the angiotensin II receptor AT1 and plasma renin activity, insulin resistance and reduction of blood pressure after angiotensin\u2011converting enzyme inhibitor therapy?","display_name":"Is there relationship between the A1166C polymorphism of the angiotensin II receptor AT1 and plasma renin activity, insulin resistance and reduction of blood pressure after angiotensin\u2011converting enzyme inhibitor therapy?","publication_year":2008,"publication_date":"2008-04-01","ids":{"openalex":"https://openalex.org/W2442494471","doi":"https://doi.org/10.20452/pamw.358","mag":"2442494471","pmid":"https://pubmed.ncbi.nlm.nih.gov/18575418"},"language":"en","primary_location":{"id":"doi:10.20452/pamw.358","doi":"https://doi.org/10.20452/pamw.358","is_oa":false,"landing_page_url":"https://doi.org/10.20452/pamw.358","pdf_url":null,"source":{"id":"https://openalex.org/S96742272","display_name":"Polskie Archiwum Medycyny Wewn\u0119trznej","issn_l":"0032-3772","issn":["0032-3772","1897-9483"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4322632806","host_organization_name":"Medycyna Praktyczna","host_organization_lineage":["https://openalex.org/P4322632806"],"host_organization_lineage_names":["Medycyna Praktyczna"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polish Archives of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068554685","display_name":"Jerzy G\u0142uszek","orcid":"https://orcid.org/0000-0002-7584-5396","observed_orcids":["https://orcid.org/0000-0002-7584-5396"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jerzy G\u0142uszek","raw_affiliation_strings":["Chair and Clinic of Hypertensiology, Angiology and Internal Diseases, Medical University, Pozna\u0144, Poland. jerzygluszek@o2.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair and Clinic of Hypertensiology, Angiology and Internal Diseases, Medical University, Pozna\u0144, Poland. jerzygluszek@o2.pl","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045157017","display_name":"Karolina Jankowska","orcid":"https://orcid.org/0009-0005-2949-7211","observed_orcids":["https://orcid.org/0009-0005-2949-7211"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karolina Jankowska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8842,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.87599224,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"118","issue":"4","first_page":"194","last_page":"200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.8690000176429749},{"id":"https://openalex.org/keywords/a1166c-polymorphism","display_name":"A1166C polymorphism","score":0.996999979019165},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.8119999766349792},{"id":"https://openalex.org/keywords/perindopril","display_name":"perindopril","score":0.9309999942779541},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9789999723434448},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.875},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":1.0},{"id":"https://openalex.org/keywords/blood-pressure-reduction","display_name":"blood pressure reduction","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pulse-pressure","display_name":"pulse pressure","score":0.9729999899864197},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.5180000066757202},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7554953694343567},{"id":"https://openalex.org/C2779200603","wikidata":"https://www.wikidata.org/wiki/Q277785","display_name":"Perindopril","level":3,"score":0.7488048076629639},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6964266896247864},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.6788134574890137},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6267902851104736},{"id":"https://openalex.org/C149323552","wikidata":"https://www.wikidata.org/wiki/Q3090739","display_name":"Ambulatory blood pressure","level":3,"score":0.6025216579437256},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6014753580093384},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.5882076025009155},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.558803141117096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5342250466346741},{"id":"https://openalex.org/C123915805","wikidata":"https://www.wikidata.org/wiki/Q15332826","display_name":"Angiotensin II receptor type 1","level":4,"score":0.505732536315918},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4874124825000763},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.46525293588638306},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.4102345108985901},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3888675272464752},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3399215638637543},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2638188600540161},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13849565386772156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.062396496534347534}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018660","descriptor_name":"Blood Pressure Monitoring, Ambulatory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020913","descriptor_name":"Perindopril","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044140","descriptor_name":"Receptor, Angiotensin, Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.20452/pamw.358","doi":"https://doi.org/10.20452/pamw.358","is_oa":false,"landing_page_url":"https://doi.org/10.20452/pamw.358","pdf_url":null,"source":{"id":"https://openalex.org/S96742272","display_name":"Polskie Archiwum Medycyny Wewn\u0119trznej","issn_l":"0032-3772","issn":["0032-3772","1897-9483"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4322632806","host_organization_name":"Medycyna Praktyczna","host_organization_lineage":["https://openalex.org/P4322632806"],"host_organization_lineage_names":["Medycyna Praktyczna"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polish Archives of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:18575418","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18575418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polskie Archiwum Medycyny Wewnetrznej","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2088243584","https://openalex.org/W2382607145","https://openalex.org/W2140294673","https://openalex.org/W2122936122","https://openalex.org/W2063167493","https://openalex.org/W2040097961","https://openalex.org/W2357652415","https://openalex.org/W2353414519","https://openalex.org/W1964927312","https://openalex.org/W2369511358"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,72,121,217],"aim":[2],"of":[3,15,23,44,64,85,150,192,206,220,230,253],"this":[4],"study":[5,73],"was":[6,197],"to":[7,40],"assess":[8],"the":[9,12,16,42,61,65,148,221],"relationship":[10],"between":[11,161,186,201,247,268],"A1166C":[13,62,122,218],"polymorphism":[14,63,219],"angiotensin":[17],"AT1":[18,66,222],"receptor":[19,67,223],"gene":[20,224],"and":[21,26,33,47,90,105,112,154,176,190,204,251,271],"reduction":[22,54,153,191,205,229,252],"blood":[24,52,98,107,113,151,194,208,231,255,273],"pressure":[25,28,53,99,108,152,156,209,232,256,274],"pulse":[27,155],"in":[29,128,133,138,147,164,178,211,237,258,276],"patients":[30,76,165,180,212,238,259,277],"with":[31,57,77,81,93,101,159,166,172,213,228,235,239,260,278],"mild":[32],"moderate":[34],"arterial":[35],"hypertension.":[36,241],"Moreover,":[37],"we":[38,181],"sought":[39],"investigate":[41],"impact":[43],"insulin":[45,169,202,269],"resistance":[46,170,203,270],"plasma":[48,187,248],"renin":[49,188,249],"activity":[50,189,250],"on":[51,60],"following":[55],"treatment":[56,92,158,234],"perindopril":[58,160],"depending":[59],"gene.":[68],"PATIENTS":[69],"AND":[70],"METHODS:":[71],"included":[74],"64":[75],"mild-to-moderate":[78],"essential":[79,240],"hypertension,":[80],"a":[82,102,183,244],"mean":[83],"age":[84],"40.5":[86],"+/-16.4":[87],"years.":[88],"Before":[89],"after":[91,157,233],"angiotensin-converting":[94],"enzyme":[95],"inhibitors":[96],"(ACEI)":[97],"measurement":[100],"traditional":[103],"method":[104],"ambulatory":[106],"monitoring":[109],"were":[110,115,142],"performed":[111],"samples":[114],"taken":[116],"for":[117],"laboratory":[118],"investigation.":[119],"RESULTS:":[120],"genotype":[123,167,214,261],"distribution":[124],"was:":[125],"AA":[126,168],"53.1%":[127],"34":[129],"patients,":[130,135],"AC":[131,279],"43.8%":[132],"28":[134],"CC":[136],"3.1%":[137],"2":[139],"patients.":[140],"There":[141,196,242,263],"no":[143],"statistically":[144],"significant":[145,184],"differences":[146],"magnitude":[149],"genotypes.":[162],"Only":[163],"correlated":[171],"body":[173],"mass":[174],"index":[175],"only":[177,210,257,275],"these":[179],"observed":[182],"correlation":[185,200,246,267],"diastolic":[193,254],"pressure.":[195],"an":[198,265],"inverse":[199,266],"systolic":[207,272],"AC.":[215],"CONCLUSIONS:":[216],"is":[225,243,264],"not":[226],"associated":[227],"ACEI":[236],"negative":[245],"AA.":[262],"genotype.":[280]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}