{"id":"https://openalex.org/W2442297550","doi":"https://doi.org/10.1139/cjms53-018","title":"PARALLEL STUDIES OF COMPLEMENT AND BLOOD COAGULATION VIII. THE EFFECT OF CHOLINE AND METHIONINE ON THE CHANGES INDUCED IN GUINEA PIGS BY THE INJECTION OF CARBON TETRACHLORIDE","display_name":"PARALLEL STUDIES OF COMPLEMENT AND BLOOD COAGULATION VIII. THE EFFECT OF CHOLINE AND METHIONINE ON THE CHANGES INDUCED IN GUINEA PIGS BY THE INJECTION OF CARBON TETRACHLORIDE","publication_year":1953,"publication_date":"1953-06-01","ids":{"openalex":"https://openalex.org/W2442297550","doi":"https://doi.org/10.1139/cjms53-018","mag":"2442297550","pmid":"https://pubmed.ncbi.nlm.nih.gov/13059673"},"language":"en","primary_location":{"id":"doi:10.1139/cjms53-018","doi":"https://doi.org/10.1139/cjms53-018","is_oa":false,"landing_page_url":"https://doi.org/10.1139/cjms53-018","pdf_url":null,"source":{"id":"https://openalex.org/S2764838677","display_name":"Canadian Journal of Medical Sciences","issn_l":"0316-4403","issn":["0316-4403","0366-743X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109321971","display_name":"Christine E. Rice","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine E. Rice","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Paul Boulanger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Boulanger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027984887","display_name":"Paul Joseph Plummer","orcid":"https://orcid.org/0000-0002-5784-8382","observed_orcids":["https://orcid.org/0000-0002-5784-8382"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. J. G. Plummer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7009,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.90157155,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"3","first_page":"162","last_page":"172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.7797999978065491,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.7797999978065491,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.10849999636411667,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.02710000053048134,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":0.8889999985694885},{"id":"https://openalex.org/keywords/choline-chloride","display_name":"choline chloride","score":0.9100000262260437},{"id":"https://openalex.org/keywords/methionine","display_name":"methionine","score":1.0},{"id":"https://openalex.org/keywords/ethionine","display_name":"ethionine","score":0.9599999785423279},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.4269999861717224},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/plasma-clotting-time","display_name":"plasma clotting time","score":0.8889999985694885},{"id":"https://openalex.org/keywords/complement-c2","display_name":"complement C2","score":0.4690000116825104},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":1.0},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.8450000286102295},{"id":"https://openalex.org/keywords/prothrombin","display_name":"prothrombin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/alpha-globulin","display_name":"alpha-globulin","score":0.6859999895095825},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8610000014305115},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C2777359374","wikidata":"https://www.wikidata.org/wiki/Q225045","display_name":"Carbon tetrachloride","level":2,"score":0.8386001586914062},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6088211536407471},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.6049214601516724},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.5927073359489441},{"id":"https://openalex.org/C81358767","wikidata":"https://www.wikidata.org/wiki/Q321710","display_name":"Globulin","level":2,"score":0.5316303968429565},{"id":"https://openalex.org/C2992139802","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Clotting factor","level":2,"score":0.5116403698921204},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.4658767879009247},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.45213502645492554},{"id":"https://openalex.org/C2780486903","wikidata":"https://www.wikidata.org/wiki/Q27137089","display_name":"Ethionine","level":4,"score":0.413351833820343},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39465540647506714},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3690252900123596},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35762298107147217},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2830905020236969},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2449454665184021},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.09751641750335693},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.06999608874320984},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002251","descriptor_name":"Carbon Tetrachloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1139/cjms53-018","doi":"https://doi.org/10.1139/cjms53-018","is_oa":false,"landing_page_url":"https://doi.org/10.1139/cjms53-018","pdf_url":null,"source":{"id":"https://openalex.org/S2764838677","display_name":"Canadian Journal of Medical Sciences","issn_l":"0316-4403","issn":["0316-4403","0366-743X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Medical Sciences","raw_type":"journal-article"},{"id":"pmid:13059673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13059673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian journal of medical sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2419982826","https://openalex.org/W4313375475","https://openalex.org/W2022191846","https://openalex.org/W1974094563","https://openalex.org/W1560795060","https://openalex.org/W115003327","https://openalex.org/W2319139383","https://openalex.org/W2010509294","https://openalex.org/W2322332414","https://openalex.org/W2416103559"],"abstract_inverted_index":{"A":[0,38],"marked":[1],"prolongation":[2],"of":[3,8,20,24,47,67,76,79,81,105,123],"the":[4,9,17,48,59,73,77,82,109,118,121,124,128,130,140],"two-stage":[5],"clotting":[6,74],"time":[7,75],"plasma":[10,78],"was":[11,36,135],"produced":[12],"in":[13,41,120,132],"guinea":[14],"pigs":[15],"by":[16,127,143],"repeated":[18],"injection":[19],"small":[21],"weekly":[22],"doses":[23],"carbon":[25,83,144],"tetrachloride.":[26,145],"Ac-globulin":[27],"(labile":[28],"factor),":[29],"as":[30,32],"well":[31],"fibrinogen":[33],"and":[34,55,63,101,113],"prothrombin,":[35],"reduced.":[37],"significant":[39,95],"fall":[40],"whole":[42],"complement":[43,51,98,133],"titer":[44,134],"also":[45],"occurred;":[46],"four":[49],"major":[50],"components,":[52],"C\u2032":[53,56],"2":[54],"3":[57],"were":[58],"most":[60],"affected.":[61],"Subsequent":[62],"concurrent":[64,102],"daily":[65,103],"feedings":[66,104],"choline":[68,106],"chloride":[69,107],"or":[70],"methionine":[71],"reduced":[72],"certain":[80],"tetrachloride":[84],"treated":[85],"animals":[86],"but":[87],"not":[88,136],"to":[89],"normal":[90],"levels;":[91],"they":[92],"had":[93],"no":[94],"influence":[96],"on":[97],"titer.":[99],"Previous":[100],"ameliorated":[108],"fatty":[110],"liver":[111],"condition":[112],"gave":[114],"some":[115],"protection":[116],"against":[117],"decrease":[119],"coagulability":[122],"blood":[125],"induced":[126,142],"drug;":[129],"decline":[131],"prevented.":[137],"Ethionine":[138],"augmented":[139],"changes":[141]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
