{"id":"https://openalex.org/W2442017649","doi":"https://doi.org/10.14712/fb2013059060246","title":"Association of Gln223Arg Polymorphism of the Leptin Receptor with Hypertensive Left Ventricular Hypertrophy","display_name":"Association of Gln223Arg Polymorphism of the Leptin Receptor with Hypertensive Left Ventricular Hypertrophy","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2442017649","doi":"https://doi.org/10.14712/fb2013059060246","mag":"2442017649","pmid":"https://pubmed.ncbi.nlm.nih.gov/24485307"},"language":"en","primary_location":{"id":"doi:10.14712/fb2013059060246","doi":"https://doi.org/10.14712/fb2013059060246","is_oa":true,"landing_page_url":"https://doi.org/10.14712/fb2013059060246","pdf_url":"https://foliabiologica.lf1.cuni.cz/media/pdf/fb_2013059060246.pdf","source":{"id":"https://openalex.org/S72738211","display_name":"Folia Biologica","issn_l":"0015-5500","issn":["0015-5500","2533-7602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310314351","host_organization_name":"First Faculty of Medicine, Charles University","host_organization_lineage":["https://openalex.org/P4310314351","https://openalex.org/P4310314207"],"host_organization_lineage_names":["First Faculty of Medicine, Charles University","Charles University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Biologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://foliabiologica.lf1.cuni.cz/media/pdf/fb_2013059060246.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101963457","display_name":"Huan Zheng","orcid":"https://orcid.org/0000-0001-5663-7471","observed_orcids":["https://orcid.org/0000-0001-5663-7471"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H. Zheng","raw_affiliation_strings":["Geriatrics Department, Tongji Hospital Affiliated to Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatrics Department, Tongji Hospital Affiliated to Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N. Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"N. Xie","raw_affiliation_strings":["Geriatrics Department, Tongji Hospital Affiliated to Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatrics Department, Tongji Hospital Affiliated to Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H. Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H. Xu","raw_affiliation_strings":["Cardiology Department, Tongji Hospital Affiliated to Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Department, Tongji Hospital Affiliated to Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055950562","display_name":"Jian Huang","orcid":"https://orcid.org/0000-0001-5345-1305","observed_orcids":["https://orcid.org/0000-0001-5345-1305"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Huang","raw_affiliation_strings":["Geriatrics Department, Tongji Hospital Affiliated to Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatrics Department, Tongji Hospital Affiliated to Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100723568","display_name":"Xing Xie","orcid":"https://orcid.org/0000-0002-1636-4816","observed_orcids":["https://orcid.org/0000-0002-1636-4816","https://orcid.org/0000-0002-2426-7944"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X. Xie","raw_affiliation_strings":["Geriatrics Department, Tongji Hospital Affiliated to Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatrics Department, Tongji Hospital Affiliated to Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100440788","display_name":"Min Luo","orcid":"https://orcid.org/0000-0002-6875-7945","observed_orcids":["https://orcid.org/0000-0002-6875-7945"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Luo","raw_affiliation_strings":["Geriatrics Department, Tongji Hospital Affiliated to Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatrics Department, Tongji Hospital Affiliated to Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I116953780"],"apc_list":null,"apc_paid":null,"fwci":0.2683,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.51366436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"59","issue":"6","first_page":"246","last_page":"252"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.21080000698566437,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.21080000698566437,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.18520000576972961,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.17820000648498535,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin-receptor","display_name":"leptin receptor","score":0.9710000157356262},{"id":"https://openalex.org/keywords/gln223arg-polymorphism","display_name":"Gln223Arg polymorphism","score":0.996999979019165},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9909999966621399},{"id":"https://openalex.org/keywords/plasma-leptin","display_name":"plasma leptin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/left-ventricular-mass-index","display_name":"left ventricular mass index","score":0.9079999923706055},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.7289999723434448},{"id":"https://openalex.org/keywords/genotype-distribution","display_name":"genotype distribution","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2776002628","wikidata":"https://www.wikidata.org/wiki/Q1628627","display_name":"Left ventricular hypertrophy","level":3,"score":0.8471293449401855},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.592980146408081},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5580132603645325},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.5187442898750305},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.4958411157131195},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.48162978887557983},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.45184066891670227},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2782060503959656},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.22478815913200378},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.2158564031124115},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1498158872127533},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.13008350133895874},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09610721468925476}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.14712/fb2013059060246","doi":"https://doi.org/10.14712/fb2013059060246","is_oa":true,"landing_page_url":"https://doi.org/10.14712/fb2013059060246","pdf_url":"https://foliabiologica.lf1.cuni.cz/media/pdf/fb_2013059060246.pdf","source":{"id":"https://openalex.org/S72738211","display_name":"Folia Biologica","issn_l":"0015-5500","issn":["0015-5500","2533-7602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310314351","host_organization_name":"First Faculty of Medicine, Charles University","host_organization_lineage":["https://openalex.org/P4310314351","https://openalex.org/P4310314207"],"host_organization_lineage_names":["First Faculty of Medicine, Charles University","Charles University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Biologica","raw_type":"journal-article"},{"id":"pmid:24485307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24485307","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia biologica","raw_type":"Journal Article"},{"id":"mag:2183053427","doi":null,"is_oa":false,"landing_page_url":"https://fb.cuni.cz/file/5708/fb2013a0035.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.14712/fb2013059060246","doi":"https://doi.org/10.14712/fb2013059060246","is_oa":true,"landing_page_url":"https://doi.org/10.14712/fb2013059060246","pdf_url":"https://foliabiologica.lf1.cuni.cz/media/pdf/fb_2013059060246.pdf","source":{"id":"https://openalex.org/S72738211","display_name":"Folia Biologica","issn_l":"0015-5500","issn":["0015-5500","2533-7602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310314351","host_organization_name":"First Faculty of Medicine, Charles University","host_organization_lineage":["https://openalex.org/P4310314351","https://openalex.org/P4310314207"],"host_organization_lineage_names":["First Faculty of Medicine, Charles University","Charles University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Biologica","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2442017649.pdf","grobid_xml":"https://content.openalex.org/works/W2442017649.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W42221693","https://openalex.org/W1631449371","https://openalex.org/W1968755179","https://openalex.org/W1976914007","https://openalex.org/W1983795754","https://openalex.org/W1993088616","https://openalex.org/W1997489762","https://openalex.org/W1998616212","https://openalex.org/W2000262969","https://openalex.org/W2002588192","https://openalex.org/W2008347790","https://openalex.org/W2013143512","https://openalex.org/W2018821331","https://openalex.org/W2037200837","https://openalex.org/W2037529840","https://openalex.org/W2053965920","https://openalex.org/W2068275730","https://openalex.org/W2072367079","https://openalex.org/W2089290114","https://openalex.org/W2115350314","https://openalex.org/W2115719865","https://openalex.org/W2116649734","https://openalex.org/W2118860823","https://openalex.org/W2119801354","https://openalex.org/W2126426760","https://openalex.org/W2127717792","https://openalex.org/W2133747114","https://openalex.org/W2152899311","https://openalex.org/W2156783437","https://openalex.org/W2159721740","https://openalex.org/W2162035813","https://openalex.org/W2169878192","https://openalex.org/W2185753087","https://openalex.org/W2218441948","https://openalex.org/W2325815304","https://openalex.org/W2334337188"],"related_works":["https://openalex.org/W2183053427","https://openalex.org/W7098059991","https://openalex.org/W2353981417","https://openalex.org/W2093817147","https://openalex.org/W2372759471","https://openalex.org/W2374011190","https://openalex.org/W2194089347","https://openalex.org/W2369104327","https://openalex.org/W42221693","https://openalex.org/W1967295386"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,63,116,150,164],"aimed":[3],"to":[4],"determine":[5],"whether":[6],"the":[7,31,38,59,79,144,196,202,217,229,238,242],"leptin":[8,17,32,61,76,184,243,250],"receptor":[9,33,244],"Gln223Arg":[10,34,114,239],"polymorphism":[11,46,115,240],"has":[12],"an":[13,221],"effect":[14],"on":[15,228],"plasma":[16,60,249],"levels":[18,251],"and":[19,27,42,51,69,88,110,119,130,138,141,186,252],"left":[20,96,125,135,169,187,230,253],"ventricular":[21,97,126,136,170,188,231,254],"hypertrophy":[22,98,171,255],"in":[23,47,78,92,121,132,143,166,173,193,207,256],"hypertension.":[24,257],"The":[25,72,106,159],"genotypes":[26],"allelic":[28],"frequencies":[29],"of":[30,58,74,86,113,161,241],"were":[35,82,90,191],"examined":[36],"using":[37],"polymerase":[39],"chain":[40],"reaction":[41],"restriction":[43],"fragment":[44],"length":[45],"190":[48],"hypertensive":[49,80,93,122,208],"patients":[50,81,94,123,133,167,174,194,209],"88":[52],"healthy":[53],"controls.":[54],"Logarithmic":[55],"(log)":[56],"transformation":[57],"level":[62],"carried":[64],"out":[65],"before":[66],"performing":[67],"comparison":[68],"regression":[70,215],"analysis.":[71],"values":[73],"log(plasma":[75],"levels)":[77,185],"higher":[83,91,165,192],"than":[84,99,172,199],"those":[85,100,200],"controls":[87],"they":[89],"with":[95,124,168,195,201,248],"without":[101,134,175],"it":[102,176],"(P":[103,156,210],"<":[104,157,181,211],"0.05).":[105,158,182,212],"genotype":[107,198,206,219],"(AA,":[108],"AG,":[109],"GG)":[111],"distribution":[112],"6.8,":[117],"33.8,":[118],"59.4%":[120],"hypertrophy,":[127,137],"4.3,":[128],"27.6,":[129],"68.1%":[131],"2.3,":[139],"26.1,":[140],"71.6%":[142],"controls,":[145],"respectively.":[146],"A":[147,163],"significant":[148,226],"difference":[149],"found":[151],"among":[152],"these":[153],"three":[154],"groups":[155],"frequency":[160],"allele":[162],"(23.6":[177],"vs.":[178],"18.1%;":[179],"P":[180],"Log(plasma":[183],"mass":[189,232],"index":[190],"AA":[197,218],"AG":[203],"or":[204],"GG":[205],"In":[213],"multivariate":[214],"analysis,":[216],"as":[220],"independent":[222],"predictor":[223],"had":[224],"statistically":[225],"effects":[227],"index.":[233],"Our":[234],"results":[235],"suggest":[236],"that":[237],"is":[245],"significantly":[246],"associated":[247]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
