{"id":"https://openalex.org/W2441663719","doi":null,"title":"Interferon gamma and tumor necrosis factor alpha induce Fas expression and anti-Fas mediated apoptosis in a salivary ductal cell line.","display_name":"Interferon gamma and tumor necrosis factor alpha induce Fas expression and anti-Fas mediated apoptosis in a salivary ductal cell line.","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2441663719","mag":"2441663719","pmid":"https://pubmed.ncbi.nlm.nih.gov/10895367"},"language":"en","primary_location":{"id":"pmid:10895367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10895367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037094720","display_name":"Ryutaro Matsumura","orcid":"https://orcid.org/0000-0002-6644-243X","observed_orcids":["https://orcid.org/0000-0002-6644-243X"]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]},{"id":"https://openalex.org/I4210125448","display_name":"Toho University Medical Center Sakura Hospital","ror":"https://ror.org/02xrm8w90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125448"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R Matsumura","raw_affiliation_strings":["Department of Internal Medicine, Toho University School of Medicine, Sakura Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Toho University School of Medicine, Sakura Hospital, Japan","institution_ids":["https://openalex.org/I129634264","https://openalex.org/I4210125448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020536323","display_name":"Keiko Umemiya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Umemiya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079363553","display_name":"Tetsuhisa Goto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Goto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062513710","display_name":"Takanobu Nakazawa","orcid":"https://orcid.org/0000-0003-4863-1277","observed_orcids":["https://orcid.org/0000-0003-4863-1277"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Nakazawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039817279","display_name":"Kuniyasu Ochiai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Ochiai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113620033","display_name":"Masaru Kagami","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kagami","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040359139","display_name":"Hisao Tomioka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Tomioka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054514625","display_name":"Emiko Tanabe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Tanabe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083668667","display_name":"Toshiro Sugiyama","orcid":"https://orcid.org/0000-0001-8757-432X","observed_orcids":["https://orcid.org/0000-0001-8757-432X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Sugiyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039764681","display_name":"Makoto Sueishi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Sueishi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7186,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.83481726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"3","first_page":"311","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fas-antigen","display_name":"Fas antigen","score":0.7369999885559082},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/sialadenitis","display_name":"sialadenitis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/sjogren-s-syndrome","display_name":"Sj\u00f6gren's syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.8149999976158142},{"id":"https://openalex.org/keywords/infiltrating-lymphocytes","display_name":"infiltrating lymphocytes","score":0.847000002861023},{"id":"https://openalex.org/keywords/hsg-cell-line","display_name":"HSG cell line","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.6548928022384644},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5981271862983704},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5594809055328369},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5496540665626526},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5245647430419922},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4909341633319855},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.44865602254867554},{"id":"https://openalex.org/C3031857","wikidata":"https://www.wikidata.org/wiki/Q1649375","display_name":"Fas receptor","level":4,"score":0.43333080410957336},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.41829726099967957},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40642064809799194},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3778320848941803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36114516854286194},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.335409939289093},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.31091970205307007},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008199","descriptor_name":"Lymphadenitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008199","descriptor_name":"Lymphadenitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012859","descriptor_name":"Sjogren's Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012859","descriptor_name":"Sjogren's Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018987","descriptor_name":"Salivary Ducts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:10895367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10895367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"mag:2441663719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10895367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1558473055","https://openalex.org/W1984696190","https://openalex.org/W2003656326","https://openalex.org/W2010963898","https://openalex.org/W2056924500","https://openalex.org/W2065413461","https://openalex.org/W2069466168","https://openalex.org/W2075809552","https://openalex.org/W2078592790","https://openalex.org/W2094611205","https://openalex.org/W2117420131","https://openalex.org/W2138302361","https://openalex.org/W2162029911","https://openalex.org/W2405962820","https://openalex.org/W2409539114"],"related_works":["https://openalex.org/W2040064371","https://openalex.org/W2405962820","https://openalex.org/W2322083795","https://openalex.org/W2007689145","https://openalex.org/W2409539114","https://openalex.org/W2359357584","https://openalex.org/W1968846845","https://openalex.org/W2097941690","https://openalex.org/W1978471109","https://openalex.org/W2054285048"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1],"previously":[2],"reported":[3],"that":[4,16,56,234],"Fas":[5,23,84,96,148,187,210,215,244],"antigen":[6,85,97,149,216],"was":[7,116,152,170],"strongly":[8],"expressed":[9,183],"on":[10,209],"salivary":[11,18,105,111],"duct":[12,106,112],"epithelial":[13,41],"cells":[14,20,42,46,181,213],"and":[15,43,98,138,190,204,246],"some":[17,44],"infiltrating":[19,45,240],"showed":[21],"the":[22,57,66,75,78,93],"ligand":[24,59],"in":[25,39,65,70,86,102,150,217,249],"patients":[26],"with":[27,89,118,252],"severe":[28],"sialoadenitis":[29,69,87,250],"due":[30],"to":[31,219,225],"Sj\u00f6gren's":[32],"syndrome":[33],"(SS).":[34],"Apoptotic":[35],"changes":[36],"were":[37,223],"observed":[38],"ductal":[40,83,243,247],"by":[47,100,154,167,172,227,239],"DNA":[48,161,173],"nick":[49,174],"end":[50,175],"labeling":[51,176],"methods.":[52,177],"These":[53],"findings":[54,232],"suggest":[55,233],"Fas-Fas":[58],"system":[60],"may":[61],"play":[62],"a":[63,103],"role":[64],"pathogenesis":[67],"of":[68,77,82,95,147,160,186,196],"SS.":[71,253],"OBJECTIVE:":[72],"To":[73],"elucidate":[74],"mechanism":[76],"de":[79],"novo":[80],"expression":[81,146,245],"associated":[88,251],"SS,":[90],"we":[91],"investigated":[92],"induction":[94],"apoptosis":[99,165,226,248],"cytokines":[101],"human":[104],"cell":[107,113,156],"line.":[108],"METHODS:":[109],"Human":[110],"line":[114],"(HSG)":[115],"cultured":[117],"interferon":[119],"gamma":[120],"(IFN-gamma),":[121],"tumor":[122],"necrosis":[123],"factor":[124,143],"alpha":[125],"(TNF-alpha),":[126],"interleukin":[127,132,135],"1":[128],"beta":[129],"(IL-1":[130],"beta),":[131],"2":[133],"(IL-2),":[134],"4":[136],"(IL-4),":[137],"granulocyte":[139],"monocyte":[140],"colony":[141],"stimulating":[142],"(GM-CSF).":[144],"The":[145,158],"HSG":[151,180,212],"examined":[153],"immunoperoxidase":[155],"ELISA.":[157],"appearance":[159],"strand":[162],"breaks":[163],"during":[164],"induced":[166],"anti-Fas":[168,228],"antibody":[169],"detected":[171],"RESULTS:":[178],"Unstimulated":[179],"constitutively":[182],"low":[184],"levels":[185,195],"antigen.":[188],"IFN-gamma":[189,220,235],"TNF-alpha":[191,222,237],"consistently":[192],"upregulated":[193],"constitutive":[194],"Fas.":[197],"In":[198],"contrast,":[199],"IL-1":[200],"beta,":[201],"IL-2,":[202],"IL-4,":[203],"GM-CSF":[205],"had":[206],"no":[207],"effect":[208],"levels.":[211],"expressing":[214],"response":[218],"or":[221,236],"susceptible":[224],"antibody.":[229],"CONCLUSION:":[230],"Our":[231],"secreted":[238],"lymphocytes":[241],"induces":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
