{"id":"https://openalex.org/W2441579342","doi":"https://doi.org/10.1016/s0022-5347(17)38770-0","title":"Immunochemotherapy for Murine Bladder Tumor with a New Human Recombinant Tumor Necrosis Factor (rTNF-S), VP-16 and Hyperthermia","display_name":"Immunochemotherapy for Murine Bladder Tumor with a New Human Recombinant Tumor Necrosis Factor (rTNF-S), VP-16 and Hyperthermia","publication_year":1989,"publication_date":"1989-08-01","ids":{"openalex":"https://openalex.org/W2441579342","doi":"https://doi.org/10.1016/s0022-5347(17)38770-0","mag":"2441579342","pmid":"https://pubmed.ncbi.nlm.nih.gov/2746758"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(17)38770-0","doi":"https://doi.org/10.1016/s0022-5347(17)38770-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)38770-0","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113570710","display_name":"Tatsuo Iizumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuo Iizumi","raw_affiliation_strings":["From the Department of Urology, Teikyo University School of Medicine, Tokyo","the Biotechnology Research Center, Teikyo University, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Teikyo University School of Medicine, Tokyo","institution_ids":["https://openalex.org/I87531838"]},{"raw_affiliation_string":"the Biotechnology Research Center, Teikyo University, Kanagawa, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079291727","display_name":"Tsunetada Yazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsunetada Yazaki","raw_affiliation_strings":["From the Department of Urology, Teikyo University School of Medicine, Tokyo","the Biotechnology Research Center, Teikyo University, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Teikyo University School of Medicine, Tokyo","institution_ids":["https://openalex.org/I87531838"]},{"raw_affiliation_string":"the Biotechnology Research Center, Teikyo University, Kanagawa, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085615680","display_name":"Masayoshi Waku","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayoshi Waku","raw_affiliation_strings":["From the Department of Urology, Teikyo University School of Medicine, Tokyo","the Biotechnology Research Center, Teikyo University, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Teikyo University School of Medicine, Tokyo","institution_ids":["https://openalex.org/I87531838"]},{"raw_affiliation_string":"the Biotechnology Research Center, Teikyo University, Kanagawa, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113955234","display_name":"Gen\u2010Ichiro Soma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Gen-Ichiro Soma","raw_affiliation_strings":["From the Department of Urology, Teikyo University School of Medicine, Tokyo","the Biotechnology Research Center, Teikyo University, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Teikyo University School of Medicine, Tokyo","institution_ids":["https://openalex.org/I87531838"]},{"raw_affiliation_string":"the Biotechnology Research Center, Teikyo University, Kanagawa, Japan","institution_ids":["https://openalex.org/I87531838"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I87531838"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":2.8671,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.88656125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"142","issue":"2 Part 1","first_page":"386","last_page":"389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.75},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.8379999995231628},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.6579999923706055},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8069999814033508},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9378608465194702},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6788134574890137},{"id":"https://openalex.org/C2992225637","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder tumor","level":4,"score":0.6689493060112},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.6279937624931335},{"id":"https://openalex.org/C2992454250","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Human bladder","level":4,"score":0.6228660345077515},{"id":"https://openalex.org/C3020084786","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor \u03b1","level":3,"score":0.5986722111701965},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5848152041435242},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.453048437833786},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.45208635926246643},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.41358238458633423},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40668684244155884},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3524646759033203},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.1664307713508606},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.06189417839050293},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-5347(17)38770-0","doi":"https://doi.org/10.1016/s0022-5347(17)38770-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)38770-0","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:2746758","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2746758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1488633144","https://openalex.org/W1494937256","https://openalex.org/W1503094954","https://openalex.org/W1601157041","https://openalex.org/W1731514419","https://openalex.org/W1989783048","https://openalex.org/W2000320798","https://openalex.org/W2034295040","https://openalex.org/W2057123987","https://openalex.org/W2083726090","https://openalex.org/W2099238800","https://openalex.org/W2104199731","https://openalex.org/W2143594378","https://openalex.org/W2150858574","https://openalex.org/W2156551093","https://openalex.org/W2403137753","https://openalex.org/W2410891788"],"related_works":["https://openalex.org/W2396845183","https://openalex.org/W2403137753","https://openalex.org/W2074980223","https://openalex.org/W7145686088","https://openalex.org/W2072138523","https://openalex.org/W2414060246","https://openalex.org/W2424719397","https://openalex.org/W2072823511","https://openalex.org/W2258595633","https://openalex.org/W886869385"],"abstract_inverted_index":{"Effects":[0],"of":[1,13,22,30,45],"a":[2],"new":[3],"recombinant":[4],"human":[5,63,67],"tumor":[6,16,65],"necrosis":[7],"factor":[8],"(rTNF-S)":[9],"on":[10],"the":[11,42],"growth":[12,21],"murine":[14],"bladder":[15,64],"(MBT-2)":[17],"were":[18],"studied.":[19],"The":[20],"MBT-2":[23],"was":[24],"significantly":[25],"inhibited":[26],"by":[27],"intratumor":[28],"injection":[29],"rTNF-S.":[31,46],"Moreover":[32],"etoposide":[33],"(VP-16)":[34],"and":[35],"hyperthermia":[36],"at":[37],"relatively":[38],"low":[39],"temperature":[40],"enhanced":[41],"antitumor":[43],"effect":[44],"Since":[47],"TNF":[48],"is":[49],"considered":[50],"to":[51,60],"have":[52],"species":[53],"preference,":[54],"these":[55],"observations":[56],"may":[57],"be":[58],"relevant":[59],"treatments":[61],"for":[62],"with":[66],"TNF.":[68]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}