{"id":"https://openalex.org/W2440036655","doi":null,"title":"Ageing of the human entorhinal cortex and subicular complex.","display_name":"Ageing of the human entorhinal cortex and subicular complex.","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2440036655","mag":"2440036655","pmid":"https://pubmed.ncbi.nlm.nih.gov/1576431"},"language":"en","primary_location":{"id":"pmid:1576431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1576431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histology and histopathology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10201/18291","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058688601","display_name":"Ludwig Trillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"L Trillo","raw_affiliation_strings":["Department of Anatomy, University of Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059208519","display_name":"Gonzalo Lm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L M Gonzalo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5715,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.67378395,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"7","issue":"1","first_page":"17","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14134","display_name":"Classical Anatomy and Histology","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2702","display_name":"Anatomy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/entorhinal-cortex","display_name":"entorhinal cortex","score":0.9490000009536743},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.6600000262260437},{"id":"https://openalex.org/keywords/neuronal-loss","display_name":"neuronal loss","score":0.8360000252723694},{"id":"https://openalex.org/keywords/subiculum","display_name":"subiculum","score":0.7839999794960022},{"id":"https://openalex.org/keywords/presubiculum","display_name":"presubiculum","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nuclear-area","display_name":"nuclear area","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cortical-layers","display_name":"cortical layers","score":0.3959999978542328},{"id":"https://openalex.org/keywords/human-brain","display_name":"human brain","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C2778499278","wikidata":"https://www.wikidata.org/wiki/Q1499420","display_name":"Subiculum","level":4,"score":0.9138060808181763},{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.8263435363769531},{"id":"https://openalex.org/C37753355","wikidata":"https://www.wikidata.org/wiki/Q911877","display_name":"Nissl body","level":3,"score":0.7008056640625},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.5723901987075806},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5239413380622864},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.43362730741500854},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.4122604727745056},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3813171982765198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3694499433040619},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3510781228542328},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3495628833770752},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.305350124835968},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2779634892940521},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.25595909357070923},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21357986330986023},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.1848389208316803}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013702","descriptor_name":"Temporal Lobe","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"pmid:1576431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1576431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histology and histopathology","raw_type":"Comparative Study"},{"id":"pmh:oai:dnet:digitum_____::dc40d40fd5fafe6006bd529464f669f6","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/18291","pdf_url":"http://hdl.handle.net/10201/18291","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digitum.um.es:10201/18291","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/18291","pdf_url":null,"source":{"id":"https://openalex.org/S4306401267","display_name":"Digitum: Institutional Repository of the University of Murcia (University of Murcia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80180929","host_organization_name":"Universidad de Murcia","host_organization_lineage":["https://openalex.org/I80180929"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:hispana.mcu.es:61679998","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/18291","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2440036655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1576431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:dnet:digitum_____::dc40d40fd5fafe6006bd529464f669f6","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/18291","pdf_url":"http://hdl.handle.net/10201/18291","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320329373","display_name":"Fundaci\u00f3n Echebano","ror":"https://ror.org/01w69ev48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2440036655.pdf","grobid_xml":"https://content.openalex.org/works/W2440036655.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1704778993","https://openalex.org/W1971466598","https://openalex.org/W1981309775","https://openalex.org/W1996583890","https://openalex.org/W2003302766","https://openalex.org/W2008657099","https://openalex.org/W2014762631","https://openalex.org/W2042010146","https://openalex.org/W2046276171","https://openalex.org/W2064409479","https://openalex.org/W2071006250","https://openalex.org/W2072406115","https://openalex.org/W2093831489","https://openalex.org/W2126974689","https://openalex.org/W2151674905","https://openalex.org/W2584138911","https://openalex.org/W2739075832","https://openalex.org/W3034752398"],"related_works":["https://openalex.org/W7045002132","https://openalex.org/W6979786626","https://openalex.org/W3035308271","https://openalex.org/W2170537094","https://openalex.org/W2013853453","https://openalex.org/W2128340731","https://openalex.org/W2061082762","https://openalex.org/W4383956063","https://openalex.org/W4383906744","https://openalex.org/W2105788981"],"abstract_inverted_index":{"Age-dependent":[0],"changes":[1,229],"in":[2,13,41,46,74,87,96,176,230],"the":[3,81,85,88,92,100,124,132,143,160,165,177,193,205,215,224,228,231,241],"entorhinal":[4],"cortex":[5],"(EC)":[6],"and":[7,22,34,44,53,68,78,95,149,199,227],"subicular":[8],"complex":[9],"(SC)":[10],"were":[11,39,58,72],"studied":[12,73,106],"30":[14],"brains":[15,38],"of":[16,25,50,80,84,91,99,145,163,243],"patients":[17],"who":[18],"died":[19],"between":[20],"14":[21],"86":[23],"years":[24,123,131,157,202],"age,":[26],"without":[27],"CNS":[28],"impairment,":[29],"as":[30],"determined":[31],"by":[32,60],"macro-":[33],"microscopic":[35],"examination.":[36],"The":[37,137],"fixed":[40],"10%":[42],"formalin":[43],"embedded":[45],"paraffin.":[47],"Three":[48],"series":[49],"coronal":[51],"EC":[52,104],"SC":[54],"sections":[55],"(7":[56],"microns)":[57],"stained":[59],"Nissl,":[61],"PAS":[62],"or":[63],"hematoxylin-eosin.":[64],"Using":[65],"neuronal":[66,133,182,186],"count":[67],"Kariometry,":[69],"age-dependent":[70],"modifications":[71],"layers":[75,105],"II,":[76],"III":[77],"V":[79],"lateral":[82],"area":[83,139,167,195,233],"EC;":[86],"pyramidal":[89,174],"layer":[90,97,175,217],"subiculum":[93],"(S),":[94],"II":[98,218],"presubiculum":[101],"(PS).":[102],"All":[103],"presented":[107],"a":[108,180,220],"slight":[109],"(11-20%)":[110],"although":[111],"significant":[112,181],"reduction":[113,187],"up":[114,141,154,203],"to":[115,121,142,155,204,240],"35":[116,120,201],"years,":[117,147,173,192],"but":[118],"from":[119,151,200],"75":[122,130,156],"decrease":[125],"was":[126,188],"not":[127,169,235],"significant.":[128],"After":[129],"loss":[134,183,222],"increased":[135,211],"slightly.":[136],"nuclear":[138,166,194,232],"decreased":[140,196],"age":[144,153,208],"40-45":[146],"(10-18%)":[148],"augmented":[150],"this":[152],"(10-14%).":[158],"During":[159],"last":[161],"period":[162],"life,":[164],"did":[168,234],"change.":[170],"From":[171],"30-60":[172],"S":[178],"showed":[179],"(30%),":[184],"thereafter,":[185],"less.":[189],"At":[190],"early":[191],"insignificantly":[197],"(15%),":[198],"most":[206],"advanced":[207],"studied,":[209],"it":[210],"significantly":[212],"(13%).":[213],"In":[214],"PS,":[216],"manifested":[219],"cell":[221],"throughout":[223],"lifespan":[225],"(32.9%)":[226],"reach":[236],"statistical":[237],"significance":[238],"due":[239],"dispersions":[242],"its":[244],"values.(ABSTRACT":[245],"TRUNCATED":[246],"AT":[247],"250":[248],"WORDS)":[249]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}