{"id":"https://openalex.org/W2439905200","doi":null,"title":"A linear model relating breath concentrations to environmental exposures: application to a chamber study of four volunteers exposed to volatile organic chemicals.","display_name":"A linear model relating breath concentrations to environmental exposures: application to a chamber study of four volunteers exposed to volatile organic chemicals.","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2439905200","mag":"2439905200","pmid":"https://pubmed.ncbi.nlm.nih.gov/8518547"},"language":"en","primary_location":{"id":"pmid:8518547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8518547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of exposure analysis and environmental epidemiology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000860525","display_name":"Lance Arthur Wallace","orcid":"https://orcid.org/0000-0002-6635-2303","observed_orcids":["https://orcid.org/0000-0002-6635-2303"]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Wallace","raw_affiliation_strings":["U.S. Environmental Protection Agency, Warrenton, Virginia 22091"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Environmental Protection Agency, Warrenton, Virginia 22091","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000369709","display_name":"Edo D. Pellizzari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Pellizzari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5056122538","display_name":"S. Gordon","orcid":"https://orcid.org/0009-0005-7002-490X","observed_orcids":["https://orcid.org/0009-0005-7002-490X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Gordon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2222,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.91514501,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"3","issue":"1","first_page":"75","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11002","display_name":"Indoor Air Quality and Microbial Exposure","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/volatile-organic-compounds","display_name":"volatile organic compounds","score":0.777999997138977},{"id":"https://openalex.org/keywords/mass-balance-modeling","display_name":"mass balance model","score":0.6700000166893005},{"id":"https://openalex.org/keywords/compartmental-model","display_name":"compartmental model","score":0.6949999928474426},{"id":"https://openalex.org/keywords/residence-time","display_name":"residence time","score":0.8370000123977661},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.5609999895095825},{"id":"https://openalex.org/keywords/tetrachloroethylene","display_name":"tetrachloroethylene","score":0.8080000281333923},{"id":"https://openalex.org/keywords/xylene","display_name":"xylene","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ethylbenzene","display_name":"ethylbenzene","score":0.9879999756813049}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5545604228973389},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.5405662655830383},{"id":"https://openalex.org/C3020341094","wikidata":"https://www.wikidata.org/wiki/Q9530","display_name":"Exhaled air","level":2,"score":0.5347105264663696},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.5049312710762024},{"id":"https://openalex.org/C2775913793","wikidata":"https://www.wikidata.org/wiki/Q3030793","display_name":"Residence time (fluid dynamics)","level":2,"score":0.5037252306938171},{"id":"https://openalex.org/C195289149","wikidata":"https://www.wikidata.org/wiki/Q2256694","display_name":"Toxicokinetics","level":3,"score":0.5002069473266602},{"id":"https://openalex.org/C2779777708","wikidata":"https://www.wikidata.org/wiki/Q6033622","display_name":"Inhalation exposure","level":3,"score":0.4951426088809967},{"id":"https://openalex.org/C2778150766","wikidata":"https://www.wikidata.org/wiki/Q910267","display_name":"Volatile organic compound","level":2,"score":0.4929513931274414},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.4643023610115051},{"id":"https://openalex.org/C2987845665","wikidata":"https://www.wikidata.org/wiki/Q17072363","display_name":"Occupational exposure","level":2,"score":0.4526521861553192},{"id":"https://openalex.org/C2778863792","wikidata":"https://www.wikidata.org/wiki/Q16909918","display_name":"TRACER","level":2,"score":0.431466281414032},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.303966224193573},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.20378971099853516},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.1449393630027771},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.13167604804039001},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12744736671447754},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09936237335205078},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001273","descriptor_name":"Atmosphere Exposure Chambers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001822","descriptor_name":"Body Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001944","descriptor_name":"Breath Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006838","descriptor_name":"Hydrocarbons","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006838","descriptor_name":"Hydrocarbons","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006838","descriptor_name":"Hydrocarbons","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8518547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8518547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of exposure analysis and environmental epidemiology","raw_type":"Journal Article"},{"id":"mag:2439905200","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8518547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W37029581","https://openalex.org/W153617108","https://openalex.org/W1972613513","https://openalex.org/W1979339992","https://openalex.org/W1979610882","https://openalex.org/W1991081533","https://openalex.org/W1993575199","https://openalex.org/W2049752809","https://openalex.org/W2055360296","https://openalex.org/W2077979734","https://openalex.org/W2078134333","https://openalex.org/W2114889097","https://openalex.org/W2475251991"],"related_works":["https://openalex.org/W1967653944","https://openalex.org/W37016008","https://openalex.org/W1994794188","https://openalex.org/W7095574220","https://openalex.org/W1488265491","https://openalex.org/W2425097143","https://openalex.org/W3106144910","https://openalex.org/W2416992846","https://openalex.org/W37029581","https://openalex.org/W1547178219"],"abstract_inverted_index":{"A":[0],"linear":[1],"model":[2,39,67,100,128,242],"relating":[3],"levels":[4,21],"of":[5,31,37,44,52,63,116,145,175,213,227,231,240,254,259,265,271],"volatile":[6],"organic":[7],"chemicals":[8],"(VOCs)":[9],"in":[10,27,47,72,86,96,119,126,135,217,223],"exhaled":[11,64,151],"breath":[12,263],"to":[13,41,56,113,169,199,280],"personal":[14,260],"exposures":[15,261],"at":[16,76,92],"environmental":[17],"(parts":[18],"per":[19],"billion)":[20],"has":[22,250],"been":[23],"developed":[24],"and":[25,141,163,186,220,262,278],"evaluated":[26],"a":[28,61,104,176,181,187,214,246],"chamber":[29,205,233,248],"study":[30,206,234,249],"four":[32],"human":[33],"volunteers.":[34],"The":[35,66,99,122,155,204,229],"purpose":[36],"the":[38,48,117,120,127,130,136,142,146,159,173,211,218,224,232,241],"is":[40,101,150],"allow":[42,237],"estimation":[43],"VOC":[45],"concentrations":[46,80,94,264],"body":[49],"from":[50,60,69,274],"measurements":[51],"exposure,":[53,180,185],"or":[54,78,89,110],"conversely":[55],"estimate":[57,239],"previous":[58,70],"exposure":[59,91,190,202],"measurement":[62],"breath.":[65],"differs":[68],"models":[71],"considering":[73],"long-term":[74],"inhalation":[75],"low":[77,184],"moderate":[79],"rather":[81],"than":[82],"instantaneous":[83],"intake":[84],"(as":[85,95],"drug":[87],"administration)":[88],"intermittent":[90],"high":[93,179],"occupational":[97],"situations).":[98],"based":[102],"on":[103,210],"mass":[105],"balance":[106],"approach":[107],"using":[108],"one":[109],"more":[111,200],"compartments":[112],"represent":[114],"distribution":[115],"chemical":[118],"body.":[121],"main":[123],"observable":[124],"parameters":[125,243],"are":[129,166,191],"residence":[131,208],"times":[132,209],"tau":[133],"1":[134],"compartments,":[137],"their":[138],"\"capacities\"":[139],"Ai,":[140],"fraction":[143],"f":[144,272],"parent":[147],"compound":[148],"that":[149],"under":[152],"equilibrium":[153],"conditions.":[154],"basic":[156],"equations":[157,171],"for":[158,172,244,276,283],"one-,":[160],"two-,":[161],"three-,":[162],"n-compartment":[164],"cases":[165,174],"derived.":[167],"Solutions":[168],"these":[170],"sudden":[177,182],"constant":[178,183],"linearly":[188],"increasing":[189],"provided.":[192],"These":[193],"solutions":[194],"can":[195],"be":[196],"readily":[197],"applied":[198],"complex":[201],"scenarios.":[203],"suggests":[207],"order":[212],"few":[215],"minutes":[216],"blood":[219],"1-2":[221],"hr":[222],"vessel-rich":[225],"group":[226],"tissues.":[228],"design":[230],"did":[235],"not":[236],"an":[238],"fat;":[245],"subsequent":[247],"provided":[251],"initial":[252],"estimates":[253],"50-100":[255],"hr.":[256],"Field":[257],"studies":[258],"several":[266],"hundred":[267],"persons":[268],"suggest":[269],"values":[270],"ranging":[273],"0.1":[275],"xylenes":[277],"ethylbenzene":[279],"about":[281],"0.9":[282],"tetrachloroethylene.":[284]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}