{"id":"https://openalex.org/W2438579496","doi":null,"title":"[Silicosis characterized by increasing serum CA 19-9 in parallel with progression of lung fibrosis].","display_name":"[Silicosis characterized by increasing serum CA 19-9 in parallel with progression of lung fibrosis].","publication_year":2000,"publication_date":"2000-02-01","ids":{"openalex":"https://openalex.org/W2438579496","mag":"2438579496","pmid":"https://pubmed.ncbi.nlm.nih.gov/10774174"},"language":"ja","primary_location":{"id":"pmid:10774174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10774174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113991575","display_name":"Y Totani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Totani","raw_affiliation_strings":["Third Department of Internal Medicine, Fukui Medical University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Fukui Medical University, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063376504","display_name":"Yoshiki Demura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Demura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072192808","display_name":"Shingo Ameshima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Ameshima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069201375","display_name":"Takeshi Ishizaki","orcid":"https://orcid.org/0000-0001-9512-4505","observed_orcids":["https://orcid.org/0000-0001-9512-4505"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Ishizaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076826232","display_name":"Isamu Miyamori","orcid":"https://orcid.org/0000-0002-9362-8395","observed_orcids":["https://orcid.org/0000-0002-9362-8395"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Miyamori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2466,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.58584513,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"38","issue":"2","first_page":"137","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.11289999634027481,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13759","display_name":"Medical Imaging and Pathology Studies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/silicosis","display_name":"silicosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ca19-9","display_name":"CA19-9","score":0.9900000095367432},{"id":"https://openalex.org/keywords/serum-tumor-markers","display_name":"serum tumor markers","score":0.7950000166893005},{"id":"https://openalex.org/keywords/pulmonary-interstitial-fibrosis","display_name":"interstitial pulmonary fibrosis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/idiopathic-interstitial-pneumonia","display_name":"idiopathic interstitial pneumonia","score":0.9459999799728394},{"id":"https://openalex.org/keywords/silicotic-nodules","display_name":"silicotic nodules","score":0.906000018119812},{"id":"https://openalex.org/keywords/lung-epithelial-cells","display_name":"lung epithelial cells","score":0.6970000267028809},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.5960000157356262},{"id":"https://openalex.org/keywords/miners","display_name":"miners","score":0.3540000021457672},{"id":"https://openalex.org/keywords/lung-fibrosis-progression","display_name":"lung fibrosis progression","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8767447471618652},{"id":"https://openalex.org/C2777811718","wikidata":"https://www.wikidata.org/wiki/Q653318","display_name":"Silicosis","level":2,"score":0.8076058626174927},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.6798011660575867},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6169538497924805},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5972089767456055},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.583827018737793},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.5714959502220154},{"id":"https://openalex.org/C2994364436","wikidata":"https://www.wikidata.org/wiki/Q1153419","display_name":"Interstitial pneumonia","level":3,"score":0.566682755947113},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5158990621566772},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4999661445617676},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.49217596650123596},{"id":"https://openalex.org/C2777543607","wikidata":"https://www.wikidata.org/wiki/Q1153419","display_name":"Interstitial lung disease","level":3,"score":0.4821188449859619},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.4750906527042389},{"id":"https://openalex.org/C2908744134","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Lung fibrosis","level":4,"score":0.4556884467601776},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4132017493247986},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.38336217403411865},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3435303270816803}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D012829","descriptor_name":"Silicosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D018395","descriptor_name":"CA-19-9 Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10774174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10774174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society","raw_type":"Case Reports"},{"id":"mag:2438579496","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10774174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2347952142","https://openalex.org/W2327145171","https://openalex.org/W2435766832","https://openalex.org/W2300798818","https://openalex.org/W2410072588","https://openalex.org/W2410022008","https://openalex.org/W1994168603","https://openalex.org/W3031457036","https://openalex.org/W2402277360","https://openalex.org/W2419052318"],"abstract_inverted_index":{"In":[0,41,80,107],"November":[1],"1997,":[2],"a":[3,18,30],"61-year-old":[4],"man":[5],"was":[6,72,105],"admitted":[7],"to":[8],"our":[9,37],"hospital":[10,38],"complaining":[11],"of":[12,32,46,66,86,115,162,165,167,173],"dyspnea.":[13],"He":[14],"had":[15,24,54],"worked":[16],"as":[17],"miner":[19],"for":[20,110],"10":[21],"years":[22],"and":[23],"received":[25],"medical":[26],"treatment":[27],"based":[28],"on":[29,101],"diagnosis":[31],"idiopathic":[33],"interstitial":[34,47,94,155],"pneumonia":[35,156],"at":[36],"since":[39,57],"1984.":[40],"conjunction":[42],"with":[43,96,120,125,154],"the":[44,49,67,83,113,141,163,171],"progression":[45],"pneumonia,":[48],"patient's":[50],"serum":[51,133,148],"CA":[52,111,134,149],"19-9":[53,127,135,150],"gradually":[55],"increased":[56,147],"1992,":[58],"reaching":[59],"9,920":[60],"U/ml":[61],"in":[62,140,152],"1997.":[63],"Though":[64],"cancer":[65],"pancreas":[68],"or":[69],"other":[70],"organs":[71],"suspected,":[73],"an":[74],"extensive":[75],"examination":[76],"revealed":[77],"no":[78],"malignancy.":[79],"April":[81],"1998,":[82],"patient":[84],"died":[85],"bacterial":[87],"pneumonia.":[88],"Lung":[89],"autopsy":[90],"specimens":[91],"disclosed":[92],"severe":[93],"fibrosis":[95],"prominent":[97],"silicotic":[98],"nodules.":[99],"Based":[100],"these":[102],"findings,":[103],"silicosis":[104],"diagnosed.":[106],"immunohistochemical":[108],"staining":[109],"19-9,":[112],"lumina":[114],"severely":[116],"fibrotic":[117],"lesions":[118],"covered":[119],"epithelial":[121,142],"cells":[122],"stained":[123],"positively":[124],"anti-CA":[126],"antibody.":[128],"These":[129],"findings":[130],"suggested":[131],"that":[132,146],"may":[136,157],"have":[137],"been":[138],"produced":[139],"cells.":[143],"We":[144],"speculated":[145],"levels":[151],"patients":[153],"occasionally":[158],"be":[159],"more":[160],"indicative":[161],"magnitude":[164],"destruction":[166],"lung":[168],"architecture":[169],"than":[170],"degree":[172],"disease":[174],"activity.":[175]},"counts_by_year":[{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}