{"id":"https://openalex.org/W2437981697","doi":null,"title":"Acyclo-retinoic acid induces apoptosis in human prostate cancer cells.","display_name":"Acyclo-retinoic acid induces apoptosis in human prostate cancer cells.","publication_year":2002,"publication_date":"2002-03-01","ids":{"openalex":"https://openalex.org/W2437981697","mag":"2437981697","pmid":"https://pubmed.ncbi.nlm.nih.gov/12014638"},"language":"en","primary_location":{"id":"pmid:12014638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12014638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034061204","display_name":"Eiichi Kotake\u2010Nara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eiichi Kotake-Nara","raw_affiliation_strings":["Department of Bioresources Chemistry, Graduate School of Fisheries Science, Hokkaido University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioresources Chemistry, Graduate School of Fisheries Science, Hokkaido University, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055988604","display_name":"Seon\u2010Jae Kim","orcid":"https://orcid.org/0000-0001-5450-9214","observed_orcids":["https://orcid.org/0000-0001-5450-9214"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seon-Jae Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084360405","display_name":"Masuko Kobori","orcid":"https://orcid.org/0000-0003-3281-5872","observed_orcids":["https://orcid.org/0000-0003-3281-5872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masuko Kobori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103167299","display_name":"Kazuo Miyashita","orcid":"https://orcid.org/0000-0001-5143-312X","observed_orcids":["https://orcid.org/0000-0001-5143-312X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuo Miyashita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109144423","display_name":"Akihiko Nagao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akihiko Nagao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0517,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.73818503,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":"2A","first_page":"689","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.6380000114440918},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/retinoids","display_name":"retinoids","score":0.8820000290870667},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.9649999737739563},{"id":"https://openalex.org/keywords/9-cis-retinoic-acid","display_name":"9-cis-retinoic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/n-4-hydroxyphenyl-retinamide","display_name":"N-(4-hydroxyphenyl)retinamide","score":0.996999979019165},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.7720000147819519},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/du145-cells","display_name":"DU145 cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.9185768365859985},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.9005316495895386},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6545383334159851},{"id":"https://openalex.org/C19431177","wikidata":"https://www.wikidata.org/wiki/Q18031041","display_name":"Retinoic acid receptor beta","level":5,"score":0.5491379499435425},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5347638726234436},{"id":"https://openalex.org/C2775954498","wikidata":"https://www.wikidata.org/wiki/Q420418","display_name":"Retinoid","level":4,"score":0.5174663662910461},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.517370879650116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5018534660339355},{"id":"https://openalex.org/C119775778","wikidata":"https://www.wikidata.org/wiki/Q18031040","display_name":"Retinoic acid receptor alpha","level":5,"score":0.49142706394195557},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45479917526245117},{"id":"https://openalex.org/C2780533455","wikidata":"https://www.wikidata.org/wiki/Q5443576","display_name":"Fenretinide","level":5,"score":0.45108187198638916},{"id":"https://openalex.org/C2779963572","wikidata":"https://www.wikidata.org/wiki/Q29417","display_name":"Tretinoin","level":4,"score":0.4395594000816345},{"id":"https://openalex.org/C139522298","wikidata":"https://www.wikidata.org/wiki/Q18031042","display_name":"Retinoic acid receptor gamma","level":5,"score":0.43897637724876404},{"id":"https://openalex.org/C89364313","wikidata":"https://www.wikidata.org/wiki/Q7316795","display_name":"Retinoic acid-inducible orphan G protein-coupled receptor","level":5,"score":0.41690561175346375},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.41288867592811584},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39565375447273254},{"id":"https://openalex.org/C120197328","wikidata":"https://www.wikidata.org/wiki/Q2838685","display_name":"Retinoic acid receptor","level":4,"score":0.31401848793029785},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.30792373418807983},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3046759068965912},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29230403900146484},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.055410146713256836}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012176","descriptor_name":"Retinoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:12014638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12014638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2437981697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12014638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2289706231","https://openalex.org/W2012376396","https://openalex.org/W2322367886","https://openalex.org/W2162269738","https://openalex.org/W1982333546","https://openalex.org/W2360510266","https://openalex.org/W2114515574","https://openalex.org/W2054967090","https://openalex.org/W2077626320","https://openalex.org/W2333294041"],"abstract_inverted_index":{"Acyclo-retinoic":[0],"acid,":[1,8,45,47,88,93],"a":[2,64],"novel":[3],"acyclic":[4],"analogue":[5],"of":[6,15,21,25,31,40,73,86,99,103],"all-trans-retinoic":[7,44,89],"has":[9],"been":[10],"previously":[11],"isolated":[12],"as":[13],"one":[14],"the":[16,29,41,71,74],"in":[17,63,105,118,129,144],"vitro":[18],"oxidation":[19],"products":[20],"lycopene.":[22],"The":[23],"effect":[24,80],"acyclo-retinoic":[26,67,113,136],"acid":[27,49,68,90,114,137],"on":[28],"growth":[30],"human":[32,145],"prostate":[33,53,146],"cancer":[34,54,147],"cells":[35,75,110],"was":[36,81,95,127],"compared":[37],"with":[38,112],"those":[39],"four":[42],"retinoids:":[43],"geranylgeranoic":[46,87],"9-cis-retinoic":[48,92],"and":[50,59,91,107],"N-(4-hydroxyphenyl)retinamide.":[51,100],"When":[52],"cells,":[55],"PC-3,":[56],"DU":[57,108],"145":[58,109],"LNCaP,":[60],"were":[61,115],"cultured":[62],"retinoid-supplemented":[65],"medium,":[66],"remarkably":[69],"reduced":[70,138],"viability":[72,140],"except":[76],"for":[77],"LNCaP.":[78],"This":[79],"significantly":[82],"higher":[83],"than":[84],"that":[85,98,135],"but":[94],"comparable":[96],"to":[97],"DNA":[101,125],"fragmentations":[102],"nuclei":[104],"PC-3":[106,130],"treated":[111],"detected":[116],"by":[117,141],"situ":[119],"TUNEL":[120],"assay.":[121],"Furthermore,":[122],"an":[123],"apoptotic":[124],"ladder":[126],"observed":[128],"cells.":[131,148],"These":[132],"results":[133],"showed":[134],"cell":[139],"inducing":[142],"apoptosis":[143]},"counts_by_year":[{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
