{"id":"https://openalex.org/W2437800359","doi":null,"title":"Deficient response of IL-6 impaired liver regeneration after hepatectomy in patients with viral hepatitis.","display_name":"Deficient response of IL-6 impaired liver regeneration after hepatectomy in patients with viral hepatitis.","publication_year":2008,"publication_date":"2008-07-01","ids":{"openalex":"https://openalex.org/W2437800359","mag":"2437800359","pmid":"https://pubmed.ncbi.nlm.nih.gov/18795707"},"language":"en","primary_location":{"id":"pmid:18795707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18795707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050545841","display_name":"Naoto Gotohda","orcid":"https://orcid.org/0000-0002-4468-5844","observed_orcids":["https://orcid.org/0000-0002-4468-5844"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoto Gotohda","raw_affiliation_strings":["Department of Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha Kashiwa, 277-8577 Chiba, Japan. ngotohda@east.ncc.go.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha Kashiwa, 277-8577 Chiba, Japan. ngotohda@east.ncc.go.jp","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113910362","display_name":"Hiromi Iwagaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromi Iwagaki","raw_affiliation_strings":["Okayama University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008868788","display_name":"Michitaka Ozaki","orcid":"https://orcid.org/0000-0003-4458-5082","observed_orcids":["https://orcid.org/0000-0003-4458-5082"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michitaka Ozaki","raw_affiliation_strings":["*** Hokkaido University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*** Hokkaido University","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111978021","display_name":"Taira Kinoshit\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taira Kinoshita","raw_affiliation_strings":["National Cancer Center Hospital East"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Center Hospital East","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077055208","display_name":"Masaru Konishi","orcid":"https://orcid.org/0000-0002-5247-2195","observed_orcids":["https://orcid.org/0000-0002-5247-2195"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Konishi","raw_affiliation_strings":["National Cancer Center Hospital East"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Center Hospital East","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085631531","display_name":"Toshio Nakagohri","orcid":"https://orcid.org/0000-0001-6843-8891","observed_orcids":["https://orcid.org/0000-0001-6843-8891"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshio Nakagohri","raw_affiliation_strings":["National Cancer Center Hospital East"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Center Hospital East","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091260536","display_name":"Shinichiro Takahashi","orcid":"https://orcid.org/0000-0002-4828-3965","observed_orcids":["https://orcid.org/0000-0002-4828-3965"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichiro Takahashi","raw_affiliation_strings":["National Cancer Center Hospital East"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Center Hospital East","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shinya Saito","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shinya Saito","raw_affiliation_strings":["Graduate School of Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Health Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101666643","display_name":"Takahito Yagi","orcid":"https://orcid.org/0000-0003-4218-1594","observed_orcids":["https://orcid.org/0000-0003-4218-1594"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takahito Yagi","raw_affiliation_strings":["University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110180983","display_name":"Noriaki Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriaki Tanaka","raw_affiliation_strings":["Okayama University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okayama University","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2172,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.696024,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"55","issue":"85","first_page":"1439","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.7929999828338623},{"id":"https://openalex.org/keywords/liver-resection","display_name":"hepatectomy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/viral-hepatitis","display_name":"viral hepatitis","score":0.7390000224113464},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9869999885559082},{"id":"https://openalex.org/keywords/soluble-fas","display_name":"soluble Fas","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cytokine-response","display_name":"cytokine response","score":0.6140000224113464},{"id":"https://openalex.org/keywords/postoperative-liver-injury","display_name":"postoperative liver injury","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2776909242","wikidata":"https://www.wikidata.org/wiki/Q1514021","display_name":"Hepatectomy","level":3,"score":0.793874204158783},{"id":"https://openalex.org/C2777072776","wikidata":"https://www.wikidata.org/wiki/Q1983841","display_name":"Viral hepatitis","level":2,"score":0.7849554419517517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7757811546325684},{"id":"https://openalex.org/C2776795407","wikidata":"https://www.wikidata.org/wiki/Q19597761","display_name":"Liver regeneration","level":3,"score":0.7320298552513123},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.5588710904121399},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5569568872451782},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.5527582764625549},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5305697321891785},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.5302265286445618},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.5140703916549683},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4800761342048645},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.4378723204135895},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.4129485487937927},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.41196519136428833},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3769225478172302},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33954334259033203},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.2256845235824585},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1577657163143158},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09884744882583618},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D048069","descriptor_name":"Tumor Necrosis Factors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18795707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18795707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Journal Article"},{"id":"mag:2437800359","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18795707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2418958410","https://openalex.org/W2215227074","https://openalex.org/W2774902412","https://openalex.org/W3007118505","https://openalex.org/W2021279231","https://openalex.org/W1826811615","https://openalex.org/W1981936620","https://openalex.org/W3149691249","https://openalex.org/W2051844808","https://openalex.org/W3031807119"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Liver":[1],"regeneration":[2,187],"after":[3,25,188],"surgical":[4],"resection":[5,36],"is":[6,14],"still":[7],"a":[8,181],"serious":[9],"concern.":[10],"The":[11],"present":[12],"study":[13],"designed":[15],"to":[16,70],"understand":[17],"the":[18,71,168],"relations":[19],"between":[20,153],"liver":[21,35,60,93,125,130,140,149,170,186,197],"injury/regeneration":[22],"and":[23,55,82,96,132],"cytokines":[24],"hepatectomy":[26,189],"with":[27,43,49,58,79,99,128,134,141,192],"viral":[28,75,80,86,142,193],"hepatitis.":[29,87],"METHODOLOGY:":[30],"Twenty-one":[31],"consecutive":[32],"patients":[33,42,48,57,78,84,191],"undergoing":[34],"were":[37,63,117],"studied,":[38],"which":[39],"included":[40],"two":[41,67,154],"biliary":[44],"tract":[45],"cancer,":[46,54],"three":[47],"hepatic":[50],"metastases":[51],"from":[52,196],"colorectal":[53],"sixteen":[56],"primary":[59],"tumor.":[61],"They":[62],"also":[64,106],"divided":[65],"into":[66],"groups":[68],"according":[69],"existence":[72],"of":[73,102,110,124,147,174],"chronic":[74],"hepatitis:":[76],"10":[77],"hepatitis":[81,90,194],"11":[83],"without":[85],"RESULTS:":[88],"Viral":[89,157],"reduced":[91,107],"pre-operative":[92],"function":[94],"(ICG-R15":[95],"platelet":[97],"count)":[98],"raised":[100],"levels":[101,121],"sFas.":[103],"Interestingly,":[104],"this":[105],"postoperative":[108,148],"surge":[109],"IL-6,":[111,175],"but":[112,144,164,176],"not":[113,166,177],"HGF,":[114,178],"though":[115],"they":[116],"equally":[118],"at":[119],"basal":[120],"pre-operatively.":[122],"Recovery":[123],"size,":[126],"calculated":[127],"resected":[129],"mass":[131],"volumetry":[133],"CT":[135],"scan,":[136],"was":[137,151],"deteriorated":[138],"in":[139,190],"hepatitis,":[143],"any":[145],"difference":[146],"damage":[150],"observed":[152],"groups.":[155],"CONCLUSIONS:":[156],"infection,":[158],"somehow,":[159],"increased":[160],"sFas":[161],"level":[162],"pre-operatively,":[163],"does":[165],"influence":[167],"post-operative":[169],"injury.":[171,198],"Deficient":[172],"response":[173],"may":[179],"be":[180],"major":[182],"cause":[183],"for":[184],"poor":[185],"independent":[195]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
