{"id":"https://openalex.org/W2437388755","doi":"https://doi.org/10.1007/978-1-61779-382-0_4","title":"High-Throughput Analysis of Mitochondrial Oxygen Consumption","display_name":"High-Throughput Analysis of Mitochondrial Oxygen Consumption","publication_year":2011,"publication_date":"2011-10-03","ids":{"openalex":"https://openalex.org/W2437388755","doi":"https://doi.org/10.1007/978-1-61779-382-0_4","mag":"2437388755","pmid":"https://pubmed.ncbi.nlm.nih.gov/22057560"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-61779-382-0_4","doi":"https://doi.org/10.1007/978-1-61779-382-0_4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-61779-382-0_4","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4242419874","display_name":"Mitochondrial Bioenergetics"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"James Hynes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"James Hynes","raw_affiliation_strings":["Luxcel Biosciences, BioInnovation Centre, UCC, Cork, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Luxcel Biosciences, BioInnovation Centre, UCC, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012930546","display_name":"Rachel L. Swiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel L. Swiss","raw_affiliation_strings":["Cell Based Assays and Mitochondrial Biology, Compound Safety Prediction \u2013 WWMC, Pfizer R&D, Eastern Point Rd, Groton, CT, 0634, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Based Assays and Mitochondrial Biology, Compound Safety Prediction \u2013 WWMC, Pfizer R&D, Eastern Point Rd, Groton, CT, 0634, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082106270","display_name":"Yvonne Will","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yvonne Will","raw_affiliation_strings":["Cell Based Assays and Mitochondrial Biology, Compound Safety Prediction \u2013 WWMC, Pfizer R&D, 558 Eastern Point Rd, Groton, CT, 06340, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Based Assays and Mitochondrial Biology, Compound Safety Prediction \u2013 WWMC, Pfizer R&D, 558 Eastern Point Rd, Groton, CT, 06340, USA","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082106270"],"corresponding_institution_ids":["https://openalex.org/I180857899"],"apc_list":null,"apc_paid":null,"fwci":3.3167,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.92425168,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1782","issue":null,"first_page":"59","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-oxygen-consumption","display_name":"mitochondrial oxygen consumption","score":0.984000027179718},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.921999990940094},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.8790000081062317},{"id":"https://openalex.org/keywords/isolated-mitochondria","display_name":"isolated mitochondria","score":0.8629999756813049},{"id":"https://openalex.org/keywords/microtiter-plate-assay","display_name":"microtiter plate assay","score":0.7379999756813049},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.6980000138282776},{"id":"https://openalex.org/keywords/compound-screening","display_name":"compound screening","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.5276452302932739},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.49913883209228516},{"id":"https://openalex.org/C30772137","wikidata":"https://www.wikidata.org/wiki/Q5164762","display_name":"Consumption (sociology)","level":2,"score":0.453576922416687},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.44261133670806885},{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.4416918158531189},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4178202450275421},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4069169759750366},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3676260709762573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3166024088859558},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2864148020744324},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21767854690551758},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.1297265589237213},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0767008364200592},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/978-1-61779-382-0_4","doi":"https://doi.org/10.1007/978-1-61779-382-0_4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-61779-382-0_4","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},{"id":"pmid:22057560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22057560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Journal Article"},{"id":"pmid:29850994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29850994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W2014414496","https://openalex.org/W2022132013","https://openalex.org/W2086034778","https://openalex.org/W2104933086","https://openalex.org/W2129968561","https://openalex.org/W2139974425"],"related_works":["https://openalex.org/W2022132013","https://openalex.org/W2166142530","https://openalex.org/W4395083261","https://openalex.org/W1826890559","https://openalex.org/W7097827571","https://openalex.org/W2018422556","https://openalex.org/W1993612120","https://openalex.org/W2549015149","https://openalex.org/W4206179465","https://openalex.org/W4385703422"],"abstract_inverted_index":{"Interest":[0],"in":[1,21,38,50],"the":[2,16,42,70,87],"investigation":[3],"of":[4,18,28,45],"mitochondrial":[5],"dysfunction":[6,20],"has":[7],"seen":[8],"a":[9,26,34,51,55],"resurgence":[10],"over":[11],"recent":[12],"years":[13],"due":[14],"to":[15,36],"implication":[17],"such":[19,39],"both":[22],"drug-induced":[23],"toxicity":[24],"and":[25,62,77,97],"variety":[27],"disease":[29],"states.":[30],"Here,":[31],"we":[32],"describe":[33,69],"methodology":[35],"assist":[37],"investigations":[40],"whereby":[41],"oxygen":[43],"consumption":[44],"isolated":[46],"mitochondria":[47],"is":[48,83],"assessed":[49],"high-throughput":[52],"fashion":[53],"using":[54],"phosphorescent":[56],"oxygen-sensitive":[57],"probe,":[58],"standard":[59],"microtitre":[60],"plates,":[61],"plate":[63,95],"reader":[64],"detection.":[65],"The":[66],"protocols":[67],"provided":[68,85],"required":[71],"isolation":[72],"procedures,":[73],"initial":[74],"assay":[75],"optimization,":[76],"subsequent":[78],"compound":[79],"screening.":[80],"Typical":[81],"data":[82,98],"also":[84],"illustrating":[86],"expected":[88],"activity":[89],"levels":[90],"as":[91,93],"well":[92],"recommended":[94],"maps":[96],"analysis":[99],"approaches.":[100]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
