{"id":"https://openalex.org/W2437178430","doi":null,"title":"HLA-binding peptides as a therapeutic approach for chronic HIV infection.","display_name":"HLA-binding peptides as a therapeutic approach for chronic HIV infection.","publication_year":2000,"publication_date":"2000-06-01","ids":{"openalex":"https://openalex.org/W2437178430","mag":"2437178430","pmid":"https://pubmed.ncbi.nlm.nih.gov/16096927"},"language":"en","primary_location":{"id":"pmid:16096927","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16096927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IDrugs : the investigational drugs journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010966529","display_name":"Alessandro Sette","orcid":"https://orcid.org/0000-0001-7013-2250","observed_orcids":["https://orcid.org/0000-0001-7013-2250"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Sette","raw_affiliation_strings":["Epimmune Inc, 6555 Nacy Ridge Drive, Suite 100, San Diego, CA 92121, USA. asette@epimmune.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epimmune Inc, 6555 Nacy Ridge Drive, Suite 100, San Diego, CA 92121, USA. asette@epimmune.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062001150","display_name":"Robert W. Chesnut","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Chesnut","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"B Livingston","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Livingston","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C Wilson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Wilson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088019995","display_name":"Mark J. Newman","orcid":"https://orcid.org/0000-0002-0433-6690","observed_orcids":["https://orcid.org/0000-0002-0433-6690"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Newman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1118,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.39378238,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"3","issue":"6","first_page":"643","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.13259999454021454,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-infection","display_name":"HIV-1 infection","score":0.7609999775886536},{"id":"https://openalex.org/keywords/multiepitope-vaccine","display_name":"multi-epitope vaccine","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.7429999709129333},{"id":"https://openalex.org/keywords/t-helper-cells","display_name":"T helper cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/dna-vaccine-delivery","display_name":"DNA vaccine delivery","score":0.6340000033378601},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.7110000252723694},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.9235782623291016},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.824813723564148},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.6429129838943481},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.634255051612854},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.6325668096542358},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5742037892341614},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5586002469062805},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5447001457214355},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5312865376472473},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5002548694610596},{"id":"https://openalex.org/C2909828532","wikidata":"https://www.wikidata.org/wiki/Q1479804","display_name":"AIDS Vaccines","level":4,"score":0.48593083024024963},{"id":"https://openalex.org/C2780195530","wikidata":"https://www.wikidata.org/wiki/Q1479804","display_name":"HIV vaccine","level":4,"score":0.45725104212760925},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4560011923313141},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.447317898273468},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43200910091400146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3504810929298401},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3269526958465576},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.2141067087650299},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13500770926475525},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.09822911024093628},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08298879861831665},{"id":"https://openalex.org/C2778190748","wikidata":"https://www.wikidata.org/wiki/Q7907956","display_name":"Vaccine trial","level":3,"score":0.07002881169319153},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:16096927","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16096927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IDrugs : the investigational drugs journal","raw_type":"Journal Article"},{"id":"mag:2437178430","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16096927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2006291622","https://openalex.org/W2150408362","https://openalex.org/W2916591029","https://openalex.org/W71889116","https://openalex.org/W2504417067","https://openalex.org/W4414493261","https://openalex.org/W2138829684","https://openalex.org/W2943966859","https://openalex.org/W2080154837","https://openalex.org/W2094690486"],"abstract_inverted_index":{"Herein,":[0],"we":[1],"describe":[2],"the":[3,64,79],"Epimmune":[4],"approach":[5],"to":[6,26,60],"prophylaxis":[7],"and":[8,34,45,53,56,62,70,74,90],"development":[9],"of":[10,16,22,48,78,85],"a":[11],"multi-epitope":[12],"vaccine":[13,89,96],"for":[14,39,72,93,99],"immunotherapy":[15],"HIV-1":[17,51],"infection.":[18],"The":[19,50,82],"central":[20],"strategy":[21],"our":[23],"program":[24],"is":[25],"induce":[27],"cellular":[28],"immune":[29],"responses,":[30],"cytotoxic":[31],"T-lymphocytes":[32],"(CTL)":[33],"helper":[35],"Tlymphocytes":[36],"(HTL),":[37],"specific":[38],"conserved":[40],"epitopes":[41,58],"from":[42],"both":[43],"structural":[44],"regulatory":[46],"proteins":[47],"HIV-1.":[49],"derived":[52],"HLA-restricted":[54],"CTL":[55],"HTL":[57],"needed":[59],"design":[61,83],"construct":[63],"experimental":[65],"vaccines":[66],"are":[67,105],"now":[68],"known":[69],"allow":[71],"broad":[73],"non-ethnically":[75],"biased":[76],"coverage":[77],"human":[80],"population.":[81],"optimization":[84],"an":[86],"epitope-based":[87],"DNA":[88,95],"evaluating":[91],"methods":[92],"various":[94],"delivery":[97],"technologies":[98],"possible":[100],"use":[101],"in":[102],"clinical":[103],"trials":[104],"addressed.":[106]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
