{"id":"https://openalex.org/W2437164522","doi":null,"title":"Interplay of transcriptomics and proteomics.","display_name":"Interplay of transcriptomics and proteomics.","publication_year":2004,"publication_date":"2004-01-15","ids":{"openalex":"https://openalex.org/W2437164522","mag":"2437164522","pmid":"https://pubmed.ncbi.nlm.nih.gov/23573645"},"language":"en","primary_location":{"id":"pmid:23573645","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23573645","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug discovery today","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110860414","display_name":"Priti S. Hegde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priti S Hegde","raw_affiliation_strings":["Department of Transcriptome Analysis, GlaxoSmithKline Pharmaceutical Research & Development, 1250 South Collegeville Road, Collegeville, PA 19426, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transcriptome Analysis, GlaxoSmithKline Pharmaceutical Research & Development, 1250 South Collegeville Road, Collegeville, PA 19426, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ian R White","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ian R White","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049868099","display_name":"Christine M. Debouck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christine Debouck","raw_affiliation_strings":["(GlaxoSmithKline)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(GlaxoSmithKline)","institution_ids":["https://openalex.org/I188950975"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5399,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.54061281,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"2 Suppl","first_page":"S53","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.19589999318122864,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.9929999709129333},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":1.0},{"id":"https://openalex.org/keywords/mrna-quantification","display_name":"mRNA quantification","score":0.7789999842643738},{"id":"https://openalex.org/keywords/protein-levels","display_name":"protein abundance","score":0.5389999747276306},{"id":"https://openalex.org/keywords/differential-splicing","display_name":"differential splicing","score":0.8299999833106995},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.9980000257492065},{"id":"https://openalex.org/keywords/data-integration","display_name":"data integration","score":0.6890000104904175},{"id":"https://openalex.org/keywords/omics-profiling","display_name":"omics profiling","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.7134966850280762},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6971695423126221},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6382063627243042},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.5435419678688049},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.494490385055542},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.475167453289032},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4734225571155548},{"id":"https://openalex.org/C2775992057","wikidata":"https://www.wikidata.org/wiki/Q16956568","display_name":"Translational efficiency","level":5,"score":0.4516125023365021},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.44503509998321533},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.4449905753135681},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3923891484737396},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34766125679016113},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.33511728048324585},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.21973916888237},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16640722751617432},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15883424878120422},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.14456039667129517},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13270145654678345},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0696149468421936},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:23573645","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23573645","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug discovery today","raw_type":"Journal Article"},{"id":"mag:2437164522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23573645","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1970357063","https://openalex.org/W2001552323","https://openalex.org/W2002396315","https://openalex.org/W2015628902","https://openalex.org/W2063333517","https://openalex.org/W2076510291","https://openalex.org/W2093772131","https://openalex.org/W2096301110","https://openalex.org/W2097846458","https://openalex.org/W2099009022","https://openalex.org/W2099317703","https://openalex.org/W2102878034","https://openalex.org/W2104820327","https://openalex.org/W2113002145","https://openalex.org/W2117736493","https://openalex.org/W2118577784","https://openalex.org/W2119908867","https://openalex.org/W2125323026","https://openalex.org/W2128424000","https://openalex.org/W2134389439","https://openalex.org/W2137983743","https://openalex.org/W2138218344","https://openalex.org/W2155470210","https://openalex.org/W2160450758","https://openalex.org/W2160930114","https://openalex.org/W2164954378","https://openalex.org/W2165454153","https://openalex.org/W2168846334","https://openalex.org/W2170949754","https://openalex.org/W2171776912","https://openalex.org/W2197805617"],"related_works":["https://openalex.org/W4409951725","https://openalex.org/W4243462007","https://openalex.org/W2463887981","https://openalex.org/W2144342921","https://openalex.org/W2032964150","https://openalex.org/W3105610505","https://openalex.org/W2014769842","https://openalex.org/W7095961351","https://openalex.org/W4284994656","https://openalex.org/W2045623213"],"abstract_inverted_index":{"Despite":[0],"the":[1,86,104],"obvious":[2],"attractions":[3],"of":[4,7,35,39,41,62,103],"parallel":[5],"profiling":[6],"transcripts":[8],"and":[9,19,60,73,77,83,91,97],"proteins":[10],"on":[11],"a":[12,29,46],"global":[13],"'omic'":[14],"scale,":[15],"there":[16],"are":[17,88,100],"practical":[18],"biological":[20],"differences":[21],"involved":[22],"in":[23,45,58,67],"their":[24],"application.":[25],"Transcriptomics":[26],"is":[27,53],"now":[28],"robust,":[30],"high-throughput,":[31],"cost-effective":[32],"technology":[33],"capable":[34],"simultaneously":[36],"quantifying":[37],"tens":[38],"thousands":[40],"defined":[42],"mRNA":[43],"species":[44],"miniaturized,":[47],"automated":[48],"format.":[49],"Conversely,":[50],"proteomic":[51,78],"analysis":[52],"currently":[54],"much":[55],"more":[56],"limited":[57],"breadth":[59],"depth":[61],"coverage":[63],"owing":[64],"to":[65,107],"variations":[66],"protein":[68],"abundance,":[69],"hydrophobicity,":[70],"stability,":[71],"size":[72],"charge.":[74],"Nevertheless,":[75],"transcriptomic":[76],"data":[79,98],"can":[80],"be":[81],"compared":[82],"contrasted":[84],"provided":[85],"studies":[87],"carefully":[89],"designed":[90],"interpreted.":[92],"Differential":[93],"splicing,":[94],"post-translational":[95],"modifications":[96],"integration":[99],"among":[101],"some":[102],"future":[105],"challenges":[106],"tackle.":[108]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
