{"id":"https://openalex.org/W2437004909","doi":"https://doi.org/10.1097/01.fbp.0000129748.60495.85","title":"Caffeine withdrawal syndrome in social interaction test in mice: Effects of the NMDA receptor channel blockers, memantine and neramexane","display_name":"Caffeine withdrawal syndrome in social interaction test in mice: Effects of the NMDA receptor channel blockers, memantine and neramexane","publication_year":2004,"publication_date":"2004-05-01","ids":{"openalex":"https://openalex.org/W2437004909","doi":"https://doi.org/10.1097/01.fbp.0000129748.60495.85","mag":"2437004909","pmid":"https://pubmed.ncbi.nlm.nih.gov/15187578"},"language":"en","primary_location":{"id":"doi:10.1097/01.fbp.0000129748.60495.85","doi":"https://doi.org/10.1097/01.fbp.0000129748.60495.85","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.fbp.0000129748.60495.85","pdf_url":null,"source":{"id":"https://openalex.org/S9181514","display_name":"Behavioural Pharmacology","issn_l":"0955-8810","issn":["0955-8810","1473-5849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045614941","display_name":"Irina A. Sukhotina","orcid":"https://orcid.org/0000-0001-7056-0925","observed_orcids":["https://orcid.org/0000-0001-7056-0925"]},"institutions":[{"id":"https://openalex.org/I193619901","display_name":"Constructor University","ror":"https://ror.org/02yrs2n53","country_code":"DE","type":"education","lineage":["https://openalex.org/I193619901"]},{"id":"https://openalex.org/I2799540354","display_name":"First Pavlov State Medical University of St. Petersburg","ror":"https://ror.org/04g525b43","country_code":"RU","type":"education","lineage":["https://openalex.org/I2799540354"]}],"countries":["DE","RU"],"is_corresponding":false,"raw_author_name":"I. A. Sukhotina","raw_affiliation_strings":["Current address: School of Engineering and Science, International University of Bremen, Research II, Campus Ring 6, PO Box 750561, D-28759 Bremen, Germany","Laboratory of Behavioral Pharmacology, Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, St. Petersburg 197089, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: School of Engineering and Science, International University of Bremen, Research II, Campus Ring 6, PO Box 750561, D-28759 Bremen, Germany","institution_ids":["https://openalex.org/I193619901"]},{"raw_affiliation_string":"Laboratory of Behavioral Pharmacology, Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, St. Petersburg 197089, Russia","institution_ids":["https://openalex.org/I2799540354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028959450","display_name":"Edwin E. Zvartau","orcid":"https://orcid.org/0000-0002-3597-7482","observed_orcids":["https://orcid.org/0000-0002-3597-7482"]},"institutions":[{"id":"https://openalex.org/I2799540354","display_name":"First Pavlov State Medical University of St. Petersburg","ror":"https://ror.org/04g525b43","country_code":"RU","type":"education","lineage":["https://openalex.org/I2799540354"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. E. Zvartau","raw_affiliation_strings":["Laboratory of Behavioral Pharmacology, Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, St. Petersburg 197089, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Behavioral Pharmacology, Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, St. Petersburg 197089, Russia","institution_ids":["https://openalex.org/I2799540354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060706996","display_name":"Wojciech Danysz","orcid":"https://orcid.org/0000-0003-2375-0210","observed_orcids":["https://orcid.org/0000-0003-2375-0210"]},"institutions":[{"id":"https://openalex.org/I4210113494","display_name":"Merz (Germany)","ror":"https://ror.org/025f1e779","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210113494"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W. Danysz","raw_affiliation_strings":["Preclinical R&D, Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical R&D, Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210113494"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061270034","display_name":"Anton Bespalov","orcid":"https://orcid.org/0000-0003-3730-1395","observed_orcids":["https://orcid.org/0000-0003-3730-1395"]},"institutions":[{"id":"https://openalex.org/I2799540354","display_name":"First Pavlov State Medical University of St. Petersburg","ror":"https://ror.org/04g525b43","country_code":"RU","type":"education","lineage":["https://openalex.org/I2799540354"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"A. Y. Bespalov","raw_affiliation_strings":["Laboratory of Behavioral Pharmacology, Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, St. Petersburg 197089, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Behavioral Pharmacology, Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, St. Petersburg 197089, Russia","institution_ids":["https://openalex.org/I2799540354"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061270034"],"corresponding_institution_ids":["https://openalex.org/I2799540354"],"apc_list":null,"apc_paid":null,"fwci":0.4442,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.5321374,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"15","issue":"3","first_page":"207","last_page":"214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.49459999799728394,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.49459999799728394,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":0.336899995803833,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.14710000157356262,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.9409999847412109},{"id":"https://openalex.org/keywords/memantine","display_name":"memantine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/social-interaction-test","display_name":"social interaction test","score":0.6200000047683716},{"id":"https://openalex.org/keywords/defensive-behavior","display_name":"defensive behavior","score":0.9319999814033508},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/caffeine-dependence","display_name":"caffeine dependence","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C2779484449","wikidata":"https://www.wikidata.org/wiki/Q412189","display_name":"Memantine","level":4,"score":0.9251601099967957},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.904029130935669},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.8454612493515015},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.5630110502243042},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5491806864738464},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4784524440765381},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41347578167915344},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3567904233932495},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2956666648387909}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008559","descriptor_name":"Memantine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008559","descriptor_name":"Memantine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012919","descriptor_name":"Social Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.fbp.0000129748.60495.85","doi":"https://doi.org/10.1097/01.fbp.0000129748.60495.85","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.fbp.0000129748.60495.85","pdf_url":null,"source":{"id":"https://openalex.org/S9181514","display_name":"Behavioural Pharmacology","issn_l":"0955-8810","issn":["0955-8810","1473-5849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Pharmacology","raw_type":"journal-article"},{"id":"pmid:15187578","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15187578","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W267545785","https://openalex.org/W1515108121","https://openalex.org/W1526412808","https://openalex.org/W1843777457","https://openalex.org/W1948376754","https://openalex.org/W1973325800","https://openalex.org/W1974574229","https://openalex.org/W1974914006","https://openalex.org/W1979201558","https://openalex.org/W1984327929","https://openalex.org/W1993609033","https://openalex.org/W1995972006","https://openalex.org/W2003311687","https://openalex.org/W2003671623","https://openalex.org/W2009547216","https://openalex.org/W2010921174","https://openalex.org/W2021162474","https://openalex.org/W2023230131","https://openalex.org/W2029045430","https://openalex.org/W2032997748","https://openalex.org/W2037508520","https://openalex.org/W2039717701","https://openalex.org/W2039994072","https://openalex.org/W2044829832","https://openalex.org/W2047020260","https://openalex.org/W2052673193","https://openalex.org/W2061506085","https://openalex.org/W2062096098","https://openalex.org/W2080664461","https://openalex.org/W2083333337","https://openalex.org/W2084578574","https://openalex.org/W2095126144","https://openalex.org/W2095171239","https://openalex.org/W2096375567","https://openalex.org/W2099210712","https://openalex.org/W2103878500","https://openalex.org/W2117520655","https://openalex.org/W2118926295","https://openalex.org/W2136717001","https://openalex.org/W2163111889","https://openalex.org/W2169992401","https://openalex.org/W2170085655","https://openalex.org/W2202736130","https://openalex.org/W2271325994","https://openalex.org/W2617002364","https://openalex.org/W6656240528","https://openalex.org/W6688013521"],"related_works":["https://openalex.org/W2063232113","https://openalex.org/W2003311687","https://openalex.org/W1982666112","https://openalex.org/W7097041619","https://openalex.org/W2160400737","https://openalex.org/W2094202482","https://openalex.org/W2035993896","https://openalex.org/W1178944438","https://openalex.org/W2942130775","https://openalex.org/W2278185779"],"abstract_inverted_index":{"Antagonists":[0],"acting":[1],"at":[2],"N-methyl-D-aspartate":[3],"(NMDA)":[4],"receptors":[5],"have":[6],"been":[7],"demonstrated":[8],"repeatedly":[9],"to":[10,24,120],"attenuate":[11],"the":[12,26,33,44,70,110,121,157,165,183],"expression":[13,34,166],"of":[14,28,35,38,57,73,83,103,112,130,138,167,187],"drug":[15],"and":[16,81,116],"alcohol":[17],"withdrawal":[18,40],"syndromes.":[19],"The":[20],"present":[21],"study":[22],"aimed":[23],"evaluate":[25],"effects":[27,186],"NMDA":[29,178],"receptor":[30,179],"blockade":[31,180],"on":[32],"behavioural":[36,185],"signs":[37],"caffeine":[39,58,104,114,159,188],"syndrome,":[41],"assessed":[42],"using":[43],"social":[45],"interaction":[46],"paradigm.":[47],"Adult":[48],"male":[49],"Swiss":[50],"mice":[51,131],"were":[52,76,132],"treated":[53,133],"with":[54,99,135],"increasing":[55,171],"doses":[56,137],"(40-100":[59],"mg/kg,":[60],"i.p.,":[61],"twice":[62],"daily)":[63],"for":[64],"8":[65],"days.":[66],"Twenty-four":[67],"hours":[68],"after":[69,109,156],"last":[71,158],"injection":[72],"caffeine,":[74],"there":[75],"significant":[77],"increases":[78],"in":[79],"duration":[80],"frequency":[82],"defensive":[84,168],"behaviours,":[85],"as":[86,88],"well":[87],"decreased":[89],"locomotor":[90],"activity.":[91,173],"These":[92,174],"changes":[93],"faded":[94],"within":[95],"72":[96],"hours.":[97],"Pretreatment":[98],"a":[100],"single":[101],"dose":[102],"(1":[105],"mg/kg;":[106],"24":[107,154],"h":[108,155],"end":[111],"repeated":[113],"administration":[115],"30":[117],"min":[118],"prior":[119],"test)":[122],"completely":[123],"reversed":[124],"these":[125],"withdrawal-related":[126],"changes.":[127],"Separate":[128],"groups":[129],"i.p.":[134],"different":[136],"memantine":[139],"(1,":[140],"3":[141,150],"or":[142,145,151],"10":[143,152],"mg/kg)":[144,153],"neramexane":[146],"(MRZ":[147],"2/579;":[148],"1,":[149],"injection.":[160],"Both":[161],"compounds":[162],"dose-dependently":[163],"reduced":[164],"behaviours":[169],"while":[170],"motor":[172],"data":[175],"suggest":[176],"that":[177],"may":[181],"counteract":[182],"acute":[184],"withdrawal.":[189]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
