{"id":"https://openalex.org/W2436733732","doi":"https://doi.org/10.19070/2167-910x-si03001","title":"Toxicity and Anxiolytic Property of Nettle in Mice in Light/Dark Test","display_name":"Toxicity and Anxiolytic Property of Nettle in Mice in Light/Dark Test","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2436733732","doi":"https://doi.org/10.19070/2167-910x-si03001","mag":"2436733732"},"language":"en","primary_location":{"id":"doi:10.19070/2167-910x-si03001","doi":"https://doi.org/10.19070/2167-910x-si03001","is_oa":true,"landing_page_url":"https://doi.org/10.19070/2167-910x-si03001","pdf_url":"https://doi.org/10.19070/2167-910x-si03001","source":{"id":"https://openalex.org/S4210192146","display_name":"International Journal of Clinical Pharmacology & Toxicology","issn_l":"2167-910X","issn":["2167-910X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Clinical Pharmacology & Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.19070/2167-910x-si03001","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017585320","display_name":"Zouhra Doukkali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Doukkali Z","raw_affiliation_strings":["Pharmacodynamy Research Team, ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat .Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacodynamy Research Team, ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat .Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083394825","display_name":"Khalid Taghzouti","orcid":"https://orcid.org/0000-0002-5638-3368","observed_orcids":["https://orcid.org/0000-0002-5638-3368"]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Taghzouti K","raw_affiliation_strings":["Pharmacodynamy Research Team, ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat .Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacodynamy Research Team, ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat .Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096241175","display_name":"Bouidida El H","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]},{"id":"https://openalex.org/I4210107929","display_name":"Minist\u00e8re de la Sant\u00e9","ror":"https://ror.org/01m2sr579","country_code":"MA","type":"government","lineage":["https://openalex.org/I4210107929"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Bouidida El H","raw_affiliation_strings":["Laboratory of Animal Physiology, Department of Biology -Faculty of Science -University Mohammed V of Rabat, Morocco","National Laboratory of Drug Control, Directorate of Pharmacy, Ministry of Health, Rabat, Morocco","Pharmacodynamy Research Team, ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat .Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Physiology, Department of Biology -Faculty of Science -University Mohammed V of Rabat, Morocco","institution_ids":["https://openalex.org/I126477371"]},{"raw_affiliation_string":"National Laboratory of Drug Control, Directorate of Pharmacy, Ministry of Health, Rabat, Morocco","institution_ids":["https://openalex.org/I4210107929"]},{"raw_affiliation_string":"Pharmacodynamy Research Team, ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat .Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kamal R","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Kamal R","raw_affiliation_strings":["Pharmacodynamy Research Team, ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat .Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacodynamy Research Team, ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat .Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052817555","display_name":"Jemeli Me","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"El Jemeli M","raw_affiliation_strings":["Pharmacodynamy Research Team, ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat .Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacodynamy Research Team, ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat .Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096137399","display_name":"B Bahia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]},{"id":"https://openalex.org/I4210107929","display_name":"Minist\u00e8re de la Sant\u00e9","ror":"https://ror.org/01m2sr579","country_code":"MA","type":"government","lineage":["https://openalex.org/I4210107929"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Bahia B","raw_affiliation_strings":["Laboratory of Animal Physiology, Department of Biology -Faculty of Science -University Mohammed V of Rabat, Morocco","National Laboratory of Drug Control, Directorate of Pharmacy, Ministry of Health, Rabat, Morocco","Pharmacodynamy Research Team, ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat .Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Physiology, Department of Biology -Faculty of Science -University Mohammed V of Rabat, Morocco","institution_ids":["https://openalex.org/I126477371"]},{"raw_affiliation_string":"National Laboratory of Drug Control, Directorate of Pharmacy, Ministry of Health, Rabat, Morocco","institution_ids":["https://openalex.org/I4210107929"]},{"raw_affiliation_string":"Pharmacodynamy Research Team, ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat .Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zellou A","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zellou A","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081773019","display_name":"Yahia Cherrah","orcid":"https://orcid.org/0000-0001-7890-9028","observed_orcids":["https://orcid.org/0000-0001-7890-9028"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cherrah Y","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070920676","display_name":"Katim Alaoui","orcid":"https://orcid.org/0000-0001-8106-1400","observed_orcids":["https://orcid.org/0000-0001-8106-1400"]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Alaoui K","raw_affiliation_strings":["Pharmacodynamy Research Team, ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat .Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacodynamy Research Team, ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat .Morocco","institution_ids":["https://openalex.org/I126477371"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urtica-urens","display_name":"Urtica urens","score":0.9959999918937683},{"id":"https://openalex.org/keywords/urtica-dioica","display_name":"Urtica dioica","score":0.9100000262260437},{"id":"https://openalex.org/keywords/anxiolytic-effects","display_name":"anxiolytic effects","score":0.9909999966621399},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.7549999952316284},{"id":"https://openalex.org/keywords/plant-aqueous-extracts","display_name":"aqueous plant extract","score":0.9229999780654907},{"id":"https://openalex.org/keywords/light-dark-test","display_name":"light/dark test","score":0.8289999961853027},{"id":"https://openalex.org/keywords/hole-board-test","display_name":"hole board test","score":0.9670000076293945},{"id":"https://openalex.org/keywords/motor-coordination","display_name":"motor coordination","score":0.7379999756813049},{"id":"https://openalex.org/keywords/diazepam-comparison","display_name":"diazepam comparison","score":0.906000018119812},{"id":"https://openalex.org/keywords/toxicity","display_name":"toxicity","score":0.5550000071525574},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.8967918753623962},{"id":"https://openalex.org/C2779309145","wikidata":"https://www.wikidata.org/wiki/Q156332","display_name":"Urticaceae","level":2,"score":0.8431220054626465},{"id":"https://openalex.org/C2776175493","wikidata":"https://www.wikidata.org/wiki/Q210402","display_name":"Diazepam","level":2,"score":0.7404041290283203},{"id":"https://openalex.org/C2779964429","wikidata":"https://www.wikidata.org/wiki/Q155909","display_name":"Urtica dioica","level":2,"score":0.5550577044487},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4775577187538147},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.44562849402427673},{"id":"https://openalex.org/C3019987054","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Dose dependence","level":2,"score":0.41361916065216064},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3348623514175415},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.33265161514282227},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.25678759813308716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2362641990184784},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2152608335018158},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.17868822813034058}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.19070/2167-910x-si03001","doi":"https://doi.org/10.19070/2167-910x-si03001","is_oa":true,"landing_page_url":"https://doi.org/10.19070/2167-910x-si03001","pdf_url":"https://doi.org/10.19070/2167-910x-si03001","source":{"id":"https://openalex.org/S4210192146","display_name":"International Journal of Clinical Pharmacology & Toxicology","issn_l":"2167-910X","issn":["2167-910X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Clinical Pharmacology & Toxicology","raw_type":"journal-article"},{"id":"pmh:oai:zenodo.org:581596","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/581596","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.19070/2167-910x-si03001","doi":"https://doi.org/10.19070/2167-910x-si03001","is_oa":true,"landing_page_url":"https://doi.org/10.19070/2167-910x-si03001","pdf_url":"https://doi.org/10.19070/2167-910x-si03001","source":{"id":"https://openalex.org/S4210192146","display_name":"International Journal of Clinical Pharmacology & Toxicology","issn_l":"2167-910X","issn":["2167-910X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Clinical Pharmacology & Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2436733732.pdf","grobid_xml":"https://content.openalex.org/works/W2436733732.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1544253758","https://openalex.org/W1601975099","https://openalex.org/W1968013271","https://openalex.org/W1971824229","https://openalex.org/W1982569952","https://openalex.org/W2013082402","https://openalex.org/W2018021139","https://openalex.org/W2027389756","https://openalex.org/W2042376377","https://openalex.org/W2053486952","https://openalex.org/W2059314981","https://openalex.org/W2087334124","https://openalex.org/W2092905403","https://openalex.org/W2093381287","https://openalex.org/W2094332833","https://openalex.org/W2120996135","https://openalex.org/W2129729739","https://openalex.org/W2157657913","https://openalex.org/W2318756733","https://openalex.org/W2957455061","https://openalex.org/W4255654115","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2129729739","https://openalex.org/W2496566279","https://openalex.org/W2306183338","https://openalex.org/W7157001261","https://openalex.org/W3164295327","https://openalex.org/W2616946987","https://openalex.org/W4408009205","https://openalex.org/W2039188314","https://openalex.org/W2011783213","https://openalex.org/W2138294843"],"abstract_inverted_index":{"Background:":[0],"Anxiety":[1],"is":[2,18],"an":[3,51],"unpleasant":[4],"state":[5],"of":[6,27,33,45,48,91,118,128,176,194],"inner":[7],"turmoil":[8],"often":[9],"accompanied":[10],"by":[11,73],"cognitive,":[12],"somatic,":[13],"emotional,":[14],"and":[15,53,77,82,156,186],"behavioral":[16],"components.There":[17],"some":[19],"evidence":[20],"in":[21,30,35,114,125,160,179],"traditional":[22,184],"medicine":[23],"for":[24,56,173],"the":[25,31,70,78,86,92,100,111,115,119,126,130,137,140,145,149],"effectiveness":[26],"Urtica":[28,49,177,195],"urens":[29,196],"treatment":[32],"anxiety":[34],"humans.The":[36],"present":[37],"study":[38,42],"was":[39,67,97,143],"designed":[40],"to":[41,61,136,162,198],"anxiolytic":[43,65,102,174],"property":[44],"aqueous":[46],"extracts":[47],"urens;":[50],"important":[52],"commonly":[54],"used":[55],"its":[57,182],"medicinal":[58,183],"properties":[59],"belongs":[60],"urticaceae":[62],"family.Methods:":[63],"The":[64],"activity":[66,175],"evaluated":[68],"with":[69,85,99,181],"adult":[71],"mice":[72],"hole":[74,146],"board":[75,147],"test,":[76,81,148],"light-dark":[79],"box":[80],"motor":[83],"coordination":[84],"rota":[87,141],"rod":[88,142],"test.The":[89],"efficacy":[90],"plant":[93],"extract":[94,109,150],"(100-400":[95],"mg/kg)":[96],"compared":[98],"standard":[101],"drug":[103],"diazepam":[104],"(1":[105],"mg/kg":[106],"i.p.).":[107],"Results:The":[108],"increased":[110,152],"time":[112],"spent":[113],"brightly-lit":[116],"chamber":[117],"light/dark":[120],"box,":[121],"as":[122,124],"well":[123],"number":[127],"times":[129],"animal":[131],"crossed":[132],"from":[133],"one":[134],"compartment":[135],"other.Performance":[138],"on":[139,167],"unaffected.In":[144],"significantly":[151],"both":[153],"head-dip":[154,157],"counts":[155],"duration.Urtica":[158],"urens,":[159,178],"contrast":[161],"diazepam,":[163],"had":[164],"no":[165],"effect":[166],"locomotion.Conclusions:":[168],"These":[169],"results":[170],"provides":[171],"support":[172],"line":[180],"use,":[185],"may":[187],"also":[188],"suggest":[189],"a":[190],"better":[191],"side-effect":[192],"profile":[193],"relative":[197],"diazepam.":[199]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}