{"id":"https://openalex.org/W2436665290","doi":null,"title":"Association analysis of a chemo-response signature identified within The Cancer Genome Atlas aimed at predicting genetic risk for chemo-response in ovarian cancer.","display_name":"Association analysis of a chemo-response signature identified within The Cancer Genome Atlas aimed at predicting genetic risk for chemo-response in ovarian cancer.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2436665290","mag":"2436665290","pmid":"https://pubmed.ncbi.nlm.nih.gov/27186327","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4858615"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4858615","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4858615","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Epidemiol Genet","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4858615","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112176738","display_name":"Erin A Salinas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802216851","display_name":"University of Iowa Hospitals and Clinics","ror":"https://ror.org/04g2swc55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I2802216851","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin A Salinas","raw_affiliation_strings":["Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics USA","institution_ids":["https://openalex.org/I2802216851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041825768","display_name":"Andreea Mihai Newtson","orcid":"https://orcid.org/0000-0001-7591-2483","observed_orcids":["https://orcid.org/0000-0001-7591-2483"]},"institutions":[{"id":"https://openalex.org/I2802216851","display_name":"University of Iowa Hospitals and Clinics","ror":"https://ror.org/04g2swc55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I2802216851","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andreea M Newtson","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics USA","institution_ids":["https://openalex.org/I2802216851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011828487","display_name":"Kimberly Kay Leslie","orcid":"https://orcid.org/0000-0002-2704-8990","observed_orcids":["https://orcid.org/0000-0002-2704-8990"]},"institutions":[{"id":"https://openalex.org/I2802216851","display_name":"University of Iowa Hospitals and Clinics","ror":"https://ror.org/04g2swc55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I2802216851","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly K Leslie","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics USA","institution_ids":["https://openalex.org/I2802216851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020590235","display_name":"Jes\u00fas Gonz\u00e1lez Bosquet","orcid":"https://orcid.org/0000-0002-2079-4528","observed_orcids":["https://orcid.org/0000-0002-2079-4528"]},"institutions":[{"id":"https://openalex.org/I2802216851","display_name":"University of Iowa Hospitals and Clinics","ror":"https://ror.org/04g2swc55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I2802216851","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesus Gonzalez-Bosquet","raw_affiliation_strings":["Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics USA","institution_ids":["https://openalex.org/I2802216851"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802216851"],"apc_list":null,"apc_paid":null,"fwci":0.4432,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.74320019,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"7","issue":"1","first_page":"41","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9259999990463257},{"id":"https://openalex.org/keywords/serous-ovarian-cancer","display_name":"serous ovarian cancer","score":0.9039999842643738},{"id":"https://openalex.org/keywords/chemotherapy-response","display_name":"chemotherapy response","score":0.703000009059906},{"id":"https://openalex.org/keywords/platinum-based-chemotherapy","display_name":"platinum-based chemotherapy","score":0.8069999814033508},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.8579999804496765},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9869999885559082},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7860000133514404},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.4690000116825104},{"id":"https://openalex.org/keywords/the-cancer-genome-atlas","display_name":"TCGA","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.7827287912368774},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7432160377502441},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6398925185203552},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5190578103065491},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.49018746614456177},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.4465809762477875},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.44202110171318054},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.4247703552246094},{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.41515052318573},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4117441177368164},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4053023159503937},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3982846140861511},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39401400089263916},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32873332500457764},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22165408730506897},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19899237155914307},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1696183681488037},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.06242316961288452}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4858615","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4858615","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Epidemiol Genet","raw_type":"Text"},{"id":"pmid:27186327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27186327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular epidemiology and genetics","raw_type":"Journal Article"},{"id":"mag:2436665290","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/articles/PMC4858615","pdf_url":null,"source":{"id":"https://openalex.org/S2764537520","display_name":"International Journal of Molecular Epidemiology and Genetics","issn_l":"1948-1756","issn":["1948-1756"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320994","host_organization_name":"e-Century Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310320994"],"host_organization_lineage_names":["e-Century Publishing Corporation"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Epidemiology and Genetics","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4858615","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4858615","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Epidemiol Genet","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2585911467","https://openalex.org/W2536264152","https://openalex.org/W2040904607","https://openalex.org/W2325893898","https://openalex.org/W4220923870","https://openalex.org/W2033461059","https://openalex.org/W2748131858","https://openalex.org/W2972563948","https://openalex.org/W1977550594","https://openalex.org/W2124913959"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"gene":[2],"signature":[3,43,67],"associated":[4,45,113,139],"with":[5,46,114,116,140],"chemo-response":[6,69,115,141],"in":[7,17,25,54,70,98,125,142,151,177],"ovarian":[8,56,72,143,178],"cancer":[9,73,144],"was":[10,74,96],"created":[11],"through":[12],"integration":[13],"of":[14,92,120,134,155],"biological":[15],"data":[16],"The":[18],"Cancer":[19,101],"Genome":[20],"Atlas":[21],"(TCGA)":[22],"and":[23,68,157,165],"validated":[24,128,150],"five":[26],"independent":[27],"microarray":[28],"experiments.":[29],"Our":[30],"study":[31],"aimed":[32],"to":[33,50,111,170],"determine":[34],"if":[35],"single":[36],"nucleotide":[37],"polymorphisms":[38],"(SNPs)":[39],"within":[40,64,85,129,145],"the":[41,65,77,82,86,99,121,132],"422-gene":[42,66],"were":[44,109,127,148],"a":[47,152],"genetic":[48,79,172],"predisposition":[49],"platinum-based":[51],"chemotherapy":[52],"response":[53,176],"serous":[55,71],"cancer.":[57,179],"METHODS:":[58],"An":[59],"association":[60],"analysis":[61],"between":[62],"SNPs":[63,95,108,122,138],"performed":[75],"under":[76],"log-additive":[78],"model":[80],"using":[81],"'SNPassoc'":[83],"package":[84],"R":[87],"environment":[88],"(p<0.0001).":[89],"Subsequent":[90],"validation":[91],"statistically":[93],"significant":[94,124],"done":[97],"Ovarian":[100],"Association":[102],"Consortium":[103],"(OCAC)":[104],"database.":[105],"RESULTS:":[106],"19":[107],"found":[110,123],"be":[112],"statistical":[117],"significance.":[118],"None":[119],"TCGA":[126],"OCAC":[130],"for":[131,174],"outcome":[133],"interest,":[135],"chemo-response.":[136],"CONCLUSIONS:":[137],"TGCA":[146],"database":[147,154],"not":[149],"larger":[153],"patients":[156],"controls":[158],"from":[159],"OCAC.":[160],"New":[161],"strategies":[162],"integrating":[163],"somatic":[164],"germline":[166],"information":[167],"may":[168],"help":[169],"characterize":[171],"predictors":[173],"treatment":[175]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
