{"id":"https://openalex.org/W2436497810","doi":null,"title":"Further evidence of teratogenic effects apparently produced by neurotransmitters during brain differentiation.","display_name":"Further evidence of teratogenic effects apparently produced by neurotransmitters during brain differentiation.","publication_year":1977,"publication_date":"1977-01-01","ids":{"openalex":"https://openalex.org/W2436497810","mag":"2436497810","pmid":"https://pubmed.ncbi.nlm.nih.gov/24536"},"language":"en","primary_location":{"id":"pmid:24536","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endokrinologie","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113291988","display_name":"G D\u00f6rner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G D\u00f6rner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067801448","display_name":"J Staudt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Staudt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Wenzel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Wenzel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016840247","display_name":"Richard Kv\u011bt\u0148ansk\u00fd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Kvetnansk\u00fd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069962612","display_name":"K Murgas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Murgas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7261,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.89854192,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"3","first_page":"326","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.28999999165534973,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.28999999165534973,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.26100000739097595,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.12950000166893005,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.8539999723434448},{"id":"https://openalex.org/keywords/neurotransmitters","display_name":"neurotransmitters","score":0.7829999923706055},{"id":"https://openalex.org/keywords/brain-differentiation","display_name":"brain differentiation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/pargyline","display_name":"pargyline","score":0.8510000109672546},{"id":"https://openalex.org/keywords/reserpine","display_name":"reserpine","score":0.9639999866485596},{"id":"https://openalex.org/keywords/pyridostigmine","display_name":"pyridostigmine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/monoamine-oxidase-inhibitors","display_name":"monoamine oxidase inhibitors","score":0.7829999923706055},{"id":"https://openalex.org/keywords/monoamine-depletion","display_name":"monoamine depletion","score":0.843999981880188},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibitor","display_name":"acetylcholinesterase inhibitor","score":0.9570000171661377},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9100000262260437},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9700000286102295},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":1.0},{"id":"https://openalex.org/keywords/synapse-number","display_name":"synapse number","score":0.6610000133514404},{"id":"https://openalex.org/keywords/hippocampal-ca1","display_name":"hippocampal CA1","score":0.75},{"id":"https://openalex.org/keywords/stratum-radiatum","display_name":"stratum radiatum","score":0.7599999904632568},{"id":"https://openalex.org/keywords/neonatal-drug-exposure","display_name":"neonatal drug exposure","score":0.597000002861023},{"id":"https://openalex.org/keywords/nuclear-volume","display_name":"nuclear volume","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C2777067607","wikidata":"https://www.wikidata.org/wiki/Q781329","display_name":"Pargyline","level":4,"score":0.9586167335510254},{"id":"https://openalex.org/C2777842393","wikidata":"https://www.wikidata.org/wiki/Q407841","display_name":"Reserpine","level":2,"score":0.8304891586303711},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8118414282798767},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8016581535339355},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6178810596466064},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.5675602555274963},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.5382393002510071},{"id":"https://openalex.org/C2776024655","wikidata":"https://www.wikidata.org/wiki/Q410867","display_name":"Monoamine oxidase","level":3,"score":0.5049934983253479},{"id":"https://openalex.org/C187714386","wikidata":"https://www.wikidata.org/wiki/Q420225","display_name":"Monoamine neurotransmitter","level":4,"score":0.47385528683662415},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45417898893356323},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.4538485109806061},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.43967756628990173},{"id":"https://openalex.org/C2778630814","wikidata":"https://www.wikidata.org/wiki/Q410954","display_name":"Monoamine oxidase inhibitor","level":4,"score":0.4348728060722351},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.31652379035949707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3077945113182068},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1258770227432251},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10594093799591064},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0657949149608612},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000679","descriptor_name":"Amygdala","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010293","descriptor_name":"Pargyline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011729","descriptor_name":"Pyridostigmine Bromide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012110","descriptor_name":"Reserpine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013723","descriptor_name":"Teratogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24536","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endokrinologie","raw_type":"Journal Article"},{"id":"mag:2436497810","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2473568509","https://openalex.org/W2441342597","https://openalex.org/W2033762971","https://openalex.org/W2374605769","https://openalex.org/W1990809453","https://openalex.org/W2424849377","https://openalex.org/W2039679318","https://openalex.org/W3149059462","https://openalex.org/W2049162969","https://openalex.org/W2091370592"],"abstract_inverted_index":{"1.":[0],"Adult":[1,45,116],"male":[2,46,117],"rats":[3,47,118],"treated":[4,48,119],"neonatally":[5,49,120],"with":[6,50,121],"the":[7,18,22,37,51,61,65,74,85,89,94,100,106,112,122,132,136],"monoamine":[8,52],"oxidase":[9],"inhibitor":[10,125],"pargyline":[11],"showed":[12,127],"significantly":[13,29,78,103],"increased":[14,57],"nuclear":[15,58,80],"volumes":[16,59,81],"of":[17,32,60,91,99,131,143],"nerve":[19,62],"cells":[20,63],"in":[21,36,64,71,82,93,105,109,135],"medial":[23,66],"and":[24,28,34,67],"central":[25,68],"amygdaloid":[26,69],"nuclei":[27,70],"decreased":[30,79,104],"concentrations":[31,145],"noradrenaline":[33,133],"dopamine":[35],"hypothalamus":[38],"as":[39],"compared":[40],"to":[41,73,84,111,159],"control":[42,75,113],"males.":[43,87,114],"2.":[44],"depletor":[53],"reserpine":[54],"also":[55],"displayed":[56],"comparison":[72,83,110],"males":[76,108],"but":[77],"pargylinized":[86],"Furthermore,":[88],"number":[90],"synapses":[92],"stratum":[95],"radiatum":[96],"(CA":[97],"1-region)":[98],"hippocampus":[101],"was":[102],"reserpinized":[107],"3.":[115],"acetylcholine":[123],"esterase":[124],"pyridostigmine":[126],"a":[128],"slight":[129],"decrease":[130],"concentration":[134],"hypothalamus.":[137],"These":[138],"findings":[139],"suggest":[140],"that":[141],"changes":[142],"neurotransmitter":[144],"and/or":[146],"turnover":[147],"rates":[148],"apparently":[149],"produced":[150],"by":[151],"psychotrophic":[152],"drugs":[153],"during":[154],"brain":[155],"differentiation":[156],"are":[157],"able":[158],"exert":[160],"teratogenic":[161],"effects.":[162]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}