{"id":"https://openalex.org/W2436414082","doi":null,"title":"[Effects and its mechanism of quercetin on cervical cancer HeLa cells].","display_name":"[Effects and its mechanism of quercetin on cervical cancer HeLa cells].","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W2436414082","mag":"2436414082","pmid":"https://pubmed.ncbi.nlm.nih.gov/19953944"},"language":"zh","primary_location":{"id":"pmid:19953944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19953944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua fu chan ke za zhi","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001738556","display_name":"Huang Li-qiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Qiong Huang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Renmin Hospital, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Renmin Hospital, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100688686","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0002-3326-5078","observed_orcids":["https://orcid.org/0000-0002-3326-5078"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Renmin Hospital, Wuhan University Wuhan 430060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Renmin Hospital, Wuhan University Wuhan 430060, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100397646","display_name":"Yang Yang","orcid":"https://orcid.org/0000-0002-6307-1602","observed_orcids":["https://orcid.org/0000-0002-6307-1602"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Yang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Renmin Hospital, Wuhan University Wuhan 430060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Renmin Hospital, Wuhan University Wuhan 430060, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210140357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101946525","display_name":"Tao L\u00fc","orcid":"https://orcid.org/0000-0002-0931-1257","observed_orcids":["https://orcid.org/0000-0002-0931-1257"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Tao","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Renmin Hospital, Wuhan University Wuhan 430060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Renmin Hospital, Wuhan University Wuhan 430060, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210140357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"44","issue":"6","first_page":"436","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.9070000052452087},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.7559999823570251},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.9990000128746033},{"id":"https://openalex.org/keywords/caspase-3-activation","display_name":"caspase-3 activation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.7360000014305115},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.7689999938011169},{"id":"https://openalex.org/keywords/anticancer-mechanism","display_name":"anticancer mechanism","score":0.6420000195503235},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.6159999966621399},{"id":"https://openalex.org/keywords/fluo-3-am","display_name":"Fluo-3/AM","score":0.6949999928474426},{"id":"https://openalex.org/keywords/jc-1","display_name":"JC-1","score":0.8489999771118164},{"id":"https://openalex.org/keywords/annexin-v","display_name":"annexin V","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.8909826874732971},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8425635695457458},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.7831827402114868},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.7268205881118774},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.6609184741973877},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.645607054233551},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6374011635780334},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5044845342636108},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.4999704360961914},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4797188639640808},{"id":"https://openalex.org/C2778015030","wikidata":"https://www.wikidata.org/wiki/Q410922","display_name":"Fluorescein","level":3,"score":0.45890727639198303},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.44893842935562134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3255245089530945},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30017390847206116},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2658097743988037},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.26096126437187195},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2314794957637787},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:19953944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19953944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua fu chan ke za zhi","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2356154478","https://openalex.org/W1970244921","https://openalex.org/W2380827943","https://openalex.org/W3175679627","https://openalex.org/W2313058272","https://openalex.org/W2362806484","https://openalex.org/W2100861259","https://openalex.org/W4410378533","https://openalex.org/W144681016","https://openalex.org/W1982211131"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,13,48,54,118,135,140,148,168,206,217,243,259,274],"effects":[4,188],"of":[5,15,20,51,81,108,120,128,151,171,198,208,220,226,261,269],"quercetin":[6,25,52,96,129,199],"on":[7,53],"HeLa":[8,21,92,145,227,262],"cells":[9,22,93,146,228,272],"proliferation":[10,19,136,260],"and":[11,45,87,104,110,139,161,166,181,186,242],"study":[12],"mechanism":[14],"apoptosis.":[16],"METHODS:":[17],"The":[18,79,224],"treated":[23,124],"with":[24,70,147,167,216],"at":[26],"different":[27,126,196],"concentrations":[28,127,197],"(6.25,":[29,130],"12.5,":[30,131],"25,":[31,132],"50":[32,133],"micromol/L)":[33],"for":[34],"24":[35],"hours":[36],"was":[37,65,114,137,142,214,229,245],"assessed":[38],"by":[39,67,95,99,125,195,231],"methyl":[40],"thiazolyl":[41],"tetrazolium":[42],"(MTT)":[43],"method,":[44],"also":[46],"observe":[47],"inhibitory":[49],"effect":[50],"transplanted":[55,209],"carcinoma":[56],"in":[57,91,144,211,247],"BALB/":[58],"C":[59],"nude":[60,212],"mice.":[61],"Cell":[62],"apoptosis":[63,141,169,225,268,278],"rate":[64,150,170,219],"detected":[66],"flow":[68],"cytometry":[69],"annexin":[71],"V-":[72],"fluorescein":[73],"isothiocyannate":[74],"(FITC)/propidium":[75],"iodide":[76],"(PI)":[77],"technology.":[78],"changes":[80],"intracellular":[82],"calcium":[83],"ion":[84],"concentration":[85],"([Ca2+]i)":[86],"mitochondrial":[88,236,277],"membrane":[89],"potential":[90],"induced":[94,143,230,267],"were":[97,189],"studied":[98],"laser":[100],"confocal":[101],"fluorescence":[102],"microscope":[103],"specificity":[105],"fluorescent":[106],"probes":[107],"Fluo-3/AM":[109],"JC-1.":[111],"Colorimetric":[112],"method":[113],"used":[115],"to":[116],"measure":[117],"activity":[119],"caspase-3.":[121],"RESULTS:":[122],"After":[123],"micromol/L),":[134],"inhibited":[138,215],"inhibition":[149,218],"(13.4":[152],"+/-":[153,156,159,163,173,176,179,183],"2.2)%,":[154],"(26.2":[155],"6.8)%,":[157],"(39.8":[158],"11.4)%":[160],"(48.5":[162],"9.1)%":[164],"respectively,":[165,185],"(9.0":[172],"1.4)%,":[174],"(13.3":[175],"1.1)%,":[177],"(22.5":[178],"2.3)%":[180],"(44.7":[182],"4.2)%":[184],"which":[187,233,264],"dose-dependent":[190,249],"(P":[191,251],"<":[192,252],"0.01).":[193,253],"Treated":[194],"(25,":[200],"50,":[201],"100":[202],"mg":[203],"kg(-1)":[204],"d(-1)),":[205],"growth":[207],"tumor":[210],"mice":[213],"13.4%,":[221],"30.4%,":[222],"45.8%.":[223],"quercetin,":[232],"markedly":[234],"reduced":[235],"membrance":[237],"potential,":[238],"effectively":[239],"enhance":[240],"[Ca2+]i,":[241],"caspase-3":[244],"activated":[246],"a":[248],"manner":[250],"CONCLUSION:":[254],"Quercetin":[255],"can":[256],"significantly":[257],"inhibit":[258],"cells,":[263],"may":[265],"be":[266],"cervical":[270],"cancer":[271],"via":[273],"Ca2+":[275],"-dependent":[276],"pathway.":[279]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
