{"id":"https://openalex.org/W2436070781","doi":"https://doi.org/10.1073/pnas.1607584113","title":"Closed state-coupled C-type inactivation in BK channels","display_name":"Closed state-coupled C-type inactivation in BK channels","publication_year":2016,"publication_date":"2016-06-13","ids":{"openalex":"https://openalex.org/W2436070781","doi":"https://doi.org/10.1073/pnas.1607584113","mag":"2436070781","pmid":"https://pubmed.ncbi.nlm.nih.gov/27298368","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4922147"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1607584113","doi":"https://doi.org/10.1073/pnas.1607584113","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1607584113","pdf_url":"https://www.pnas.org/content/pnas/113/25/6991.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/content/pnas/113/25/6991.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027427425","display_name":"Jiusheng Yan","orcid":"https://orcid.org/0000-0002-6633-1799","observed_orcids":["https://orcid.org/0000-0002-6633-1799"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiusheng Yan","raw_affiliation_strings":["Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438915","display_name":"Qin Li","orcid":"https://orcid.org/0000-0002-6315-4678","observed_orcids":["https://orcid.org/0000-0002-6315-4678"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qin Li","raw_affiliation_strings":["Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051410023","display_name":"Richard W. Aldrich","orcid":"https://orcid.org/0000-0001-7254-5876","observed_orcids":["https://orcid.org/0000-0001-7254-5876"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard W. Aldrich","raw_affiliation_strings":["Center for Learning and Memory, Department of Neuroscience, The University of Texas at Austin, Austin, TX 78712"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Learning and Memory, Department of Neuroscience, The University of Texas at Austin, Austin, TX 78712","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051410023"],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":null,"apc_paid":null,"fwci":0.3463,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.65879294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"113","issue":"25","first_page":"6991","last_page":"6996"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bk-channels","display_name":"BK channels","score":0.9190000295639038},{"id":"https://openalex.org/keywords/c-type-inactivation","display_name":"C-type inactivation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/closed-state","display_name":"closed state","score":0.5350000262260437},{"id":"https://openalex.org/keywords/selectivity-filter","display_name":"selectivity filter","score":0.8859999775886536},{"id":"https://openalex.org/keywords/activation-gate","display_name":"activation gate","score":0.5910000205039978},{"id":"https://openalex.org/keywords/potassium-channel-gating","display_name":"potassium channel gating","score":0.5609999895095825},{"id":"https://openalex.org/keywords/calcium-activated-potassium-channels","display_name":"calcium-activated potassium channels","score":0.6669999957084656},{"id":"https://openalex.org/keywords/hyperpolarization","display_name":"hyperpolarization","score":0.6650000214576721},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.9110000133514404},{"id":"https://openalex.org/keywords/open-probability","display_name":"open probability","score":0.671999990940094},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6658974289894104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6454931497573853},{"id":"https://openalex.org/C121932024","wikidata":"https://www.wikidata.org/wiki/Q5159376","display_name":"Conductance","level":2,"score":0.6198605298995972},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6152679920196533},{"id":"https://openalex.org/C61144316","wikidata":"https://www.wikidata.org/wiki/Q4835827","display_name":"BK channel","level":3,"score":0.574719250202179},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.52073073387146},{"id":"https://openalex.org/C149614440","wikidata":"https://www.wikidata.org/wiki/Q5018801","display_name":"Calcium-activated potassium channel","level":3,"score":0.41336846351623535},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21511265635490417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1555728316307068},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10218310356140137},{"id":"https://openalex.org/C26873012","wikidata":"https://www.wikidata.org/wiki/Q214781","display_name":"Condensed matter physics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051036","descriptor_name":"Large-Conductance Calcium-Activated Potassium Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051036","descriptor_name":"Large-Conductance Calcium-Activated Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051036","descriptor_name":"Large-Conductance Calcium-Activated Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051036","descriptor_name":"Large-Conductance Calcium-Activated Potassium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1607584113","doi":"https://doi.org/10.1073/pnas.1607584113","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1607584113","pdf_url":"https://www.pnas.org/content/pnas/113/25/6991.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4097856","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4922147","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4922147","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4922147","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:27298368","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27298368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.1607584113","doi":"https://doi.org/10.1073/pnas.1607584113","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1607584113","pdf_url":"https://www.pnas.org/content/pnas/113/25/6991.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","score":0.550000011920929,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1381118402","display_name":null,"funder_award_id":"NS07782","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5106809948","display_name":"BK channel regulation by auxiliary LRR proteins","funder_award_id":"R01NS078152","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7637402008","display_name":"SYNAPTIC INTERACTIONS IN THE CORTEX &STRIATUM","funder_award_id":"F32NS007782","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8533586074","display_name":null,"funder_award_id":"NS078152","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2436070781.pdf","grobid_xml":"https://content.openalex.org/works/W2436070781.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1233451781","https://openalex.org/W1610795025","https://openalex.org/W1886320289","https://openalex.org/W1965504965","https://openalex.org/W1972246035","https://openalex.org/W1985220992","https://openalex.org/W1989048173","https://openalex.org/W1998246673","https://openalex.org/W1998719957","https://openalex.org/W2003234320","https://openalex.org/W2015233467","https://openalex.org/W2026815132","https://openalex.org/W2031226921","https://openalex.org/W2040855917","https://openalex.org/W2047643074","https://openalex.org/W2054121895","https://openalex.org/W2057073947","https://openalex.org/W2057577050","https://openalex.org/W2063845237","https://openalex.org/W2070996372","https://openalex.org/W2073268852","https://openalex.org/W2074833991","https://openalex.org/W2082585200","https://openalex.org/W2087417757","https://openalex.org/W2090033907","https://openalex.org/W2096750690","https://openalex.org/W2098061246","https://openalex.org/W2099642662","https://openalex.org/W2105167109","https://openalex.org/W2110084070","https://openalex.org/W2116873052","https://openalex.org/W2117208932","https://openalex.org/W2122167535","https://openalex.org/W2127735309","https://openalex.org/W2143070723","https://openalex.org/W2146416602","https://openalex.org/W2151525286","https://openalex.org/W2154788230","https://openalex.org/W2157300106","https://openalex.org/W2157409937","https://openalex.org/W2164135731","https://openalex.org/W2165830038","https://openalex.org/W2166084555","https://openalex.org/W2167350525","https://openalex.org/W2406730059"],"related_works":["https://openalex.org/W2068679420","https://openalex.org/W2073346073","https://openalex.org/W2007832680","https://openalex.org/W2161839172","https://openalex.org/W2888703147","https://openalex.org/W2089036242","https://openalex.org/W2108765087","https://openalex.org/W4391642081","https://openalex.org/W4210951889","https://openalex.org/W4391641676"],"abstract_inverted_index":{"Ion":[0],"channels":[1,13,88,106,126,146,199],"regulate":[2],"ion":[3],"flow":[4],"by":[5,107],"opening":[6,154],"and":[7,28,52,89,95,155,185,213,217],"closing":[8,243],"their":[9],"pore":[10,17],"gates.":[11],"K(+)":[12,114,145],"commonly":[14],"possess":[15],"two":[16],"gates,":[18],"one":[19],"at":[20,31,76,232],"the":[21,29,32,61,72,79,91,169,233,239],"intracellular":[22,48,182],"end":[23],"for":[24,35],"fast":[25],"channel":[26,44,153,163,171,207],"activation/deactivation":[27,94],"other":[30],"selectivity":[33,80,234],"filter":[34],"slow":[36,101],"C-type":[37,56,73,84,96,102,136,141,172,201,208,225,251],"inactivation/recovery.":[38,97],"The":[39],"large-conductance":[40],"calcium-activated":[41],"potassium":[42],"(BK)":[43],"lacks":[45],"a":[46,117,131],"classic":[47],"bundle-crossing":[49],"activation":[50,64],"gate":[51,65,75],"normally":[53],"show":[54],"no":[55],"inactivation.":[57,202,252],"We":[58,82,98,203],"hypothesized":[59],"that":[60,168,205,214,238],"BK":[62,87,105,170,198,206,240],"channel's":[63,241],"may":[66,244],"spatially":[67],"overlap":[68],"or":[69,77,119,128,138,152,162,179,191],"coexist":[70],"with":[71,116,180,187,221],"inactivation":[74,85,137,142,173,209,226],"near":[78],"filter.":[81],"induced":[83],"in":[86,104,124,143],"studied":[90],"relationship":[92],"between":[93],"observed":[99],"prominent":[100],"inactivation/recovery":[103],"an":[108,246],"extreme":[109],"low":[110],"concentration":[111],"of":[112,135,250],"extracellular":[113],"together":[115],"Y294E/K/Q/S":[118],"Y279F":[120],"mutation":[121,196],"whose":[122],"equivalent":[123],"Shaker":[125],"(T449E/K/D/Q/S":[127],"W434F)":[129],"caused":[130],"greatly":[132],"accelerated":[133],"rate":[134],"constitutive":[139],"C-inactivation.":[140],"most":[144],"occurs":[147],"upon":[148],"sustained":[149],"membrane":[150,160,177,189],"depolarization":[151],"then":[156],"recovers":[157],"during":[158,175],"hyperpolarized":[159,176],"potentials":[161,178,190],"closure.":[164],"However,":[165],"we":[166,236],"found":[167],"occurred":[174],"decreased":[181],"calcium":[183],"([Ca(2+)]i)":[184],"recovered":[186],"depolarized":[188],"elevated":[192],"[Ca(2+)]i":[193],"Constitutively":[194],"open":[195],"prevented":[197],"from":[200],"concluded":[204],"is":[210],"closed":[211],"state-dependent":[212],"its":[215],"extents":[216],"rates":[218],"inversely":[219],"correlate":[220],"channel-open":[222],"probability.":[223],"Because":[224],"can":[227],"involve":[228],"multiple":[229],"conformational":[230,248],"changes":[231],"filter,":[235],"propose":[237],"normal":[242],"represent":[245],"early":[247],"stage":[249]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
