{"id":"https://openalex.org/W2436047693","doi":null,"title":"Antibody against synthetic peptide derived from Epstein-Barr virus-determined nuclear antigen 1 (EBNA-1) in child non-Hodgkin's lymphoma.","display_name":"Antibody against synthetic peptide derived from Epstein-Barr virus-determined nuclear antigen 1 (EBNA-1) in child non-Hodgkin's lymphoma.","publication_year":1990,"publication_date":"1990-04-01","ids":{"openalex":"https://openalex.org/W2436047693","mag":"2436047693","pmid":"https://pubmed.ncbi.nlm.nih.gov/1975974"},"language":"en","primary_location":{"id":"pmid:1975974","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1975974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta virologica","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031342042","display_name":"Pavel Sova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Sova","raw_affiliation_strings":["Institute of Sera and Vaccines, Prague, Czechoslovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Sera and Vaccines, Prague, Czechoslovakia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000906348","display_name":"K Roubalov\u00e1","orcid":"https://orcid.org/0000-0003-3965-1807","observed_orcids":["https://orcid.org/0000-0003-3965-1807"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Roubalov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Weinreb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Weinreb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052292378","display_name":"Eva Ham\u0161\u00edkov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Hams\u00edkov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076286235","display_name":"Roman Kodet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Kodet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006798993","display_name":"Viktor Krch\u0148\u00e1k","orcid":"https://orcid.org/0000-0001-5688-4069","observed_orcids":["https://orcid.org/0000-0001-5688-4069"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Krchn\u00e1k","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088610311","display_name":"Jaroslav Roubal I","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Roubal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34509693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"2","first_page":"132","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.08940000087022781,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13314","display_name":"Lymphadenopathy Diagnosis and Analysis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ebna1","display_name":"EBNA1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.968999981880188},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.8709999918937683},{"id":"https://openalex.org/keywords/pediatric-lymphoma","display_name":"pediatric lymphoma","score":0.8889999985694885},{"id":"https://openalex.org/keywords/anti-peptide-antibodies","display_name":"anti-peptide antibodies","score":0.8479999899864197},{"id":"https://openalex.org/keywords/synthetic-peptides","display_name":"synthetic peptides","score":0.7139999866485596},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.7850000262260437},{"id":"https://openalex.org/keywords/igm","display_name":"IgM","score":0.9990000128746033},{"id":"https://openalex.org/keywords/burkitt-lymphoma","display_name":"Burkitt lymphoma","score":0.8569999933242798},{"id":"https://openalex.org/keywords/lymphoblastic-lymphoma","display_name":"lymphoblastic lymphoma","score":0.9390000104904175},{"id":"https://openalex.org/keywords/centroblastic-lymphoma","display_name":"centroblastic lymphoma","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mediastinal-lymphoma","display_name":"mediastinal lymphoma","score":0.8299999833106995},{"id":"https://openalex.org/keywords/abdominal-lymphoma","display_name":"abdominal lymphoma","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tumor-localization","display_name":"tumor localization","score":0.4909999966621399},{"id":"https://openalex.org/keywords/histological-subtypes","display_name":"histological subtypes","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.7642590403556824},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6645188331604004},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6504947543144226},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.606639564037323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44787344336509705},{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.44191431999206543},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.41596558690071106},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40272057056427},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39653271436691284},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3900337815284729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3561166226863861}],"mesh":[{"descriptor_ui":"D000008","descriptor_name":"Abdominal Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000008","descriptor_name":"Abdominal Neoplasms","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002051","descriptor_name":"Burkitt Lymphoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002051","descriptor_name":"Burkitt Lymphoma","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1975974","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1975974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta virologica","raw_type":"Journal Article"},{"id":"mag:2436047693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1975974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2425756394","https://openalex.org/W2062786334","https://openalex.org/W1989960483","https://openalex.org/W2334322700","https://openalex.org/W1967963110","https://openalex.org/W1998015217","https://openalex.org/W1781538007","https://openalex.org/W2139160791","https://openalex.org/W1982352074","https://openalex.org/W2412258870"],"abstract_inverted_index":{"Antibody":[0],"reactivity":[1],"against":[2],"a":[3,163],"synthetic":[4],"peptide":[5],"derived":[6],"from":[7],"Epstein-Barr":[8],"virus":[9],"nuclear":[10],"antigen":[11],"1":[12],"(EBNA-1)":[13],"was":[14,58,115],"determined":[15],"in":[16,42,51,60,65,74,91,95,102,105,117,126,132,143,152,162],"56":[17],"cases":[18,97],"of":[19,98,111,140,165],"child":[20],"non-Hodgkin's":[21],"lymphoma":[22,100],"and":[23,36,38,54,77,101,131,146,157],"31":[24],"controls.":[25,167],"The":[26],"patients":[27,61],"were":[28,46,71,89,123,155],"divided":[29],"into":[30],"subgroups":[31],"based":[32],"on":[33],"tumour":[34],"location":[35],"histology":[37],"the":[39,43,66,81,106,109,138,144,149],"antibody":[40,114],"responses":[41],"various":[44],"groups":[45],"compared.":[47],"A":[48],"significant":[49],"increase":[50],"both":[52],"IgG":[53,69,87,121],"IgM":[55,113,150],"antipeptide":[56,112],"titres":[57,70,88,122,151,160],"detected":[59],"with":[62,128,137,159],"tumours":[63,130,141],"localized":[64,142],"abdomen.":[67],"High":[68],"also":[72],"noted":[73],"Burkitt-type,":[75],"lymphoblastic,":[76],"centroblastic":[78],"lymphomas.":[79,135],"On":[80],"other":[82],"hand,":[83],"low":[84,156],"or":[85],"nil":[86],"found":[90,161],"unclassified":[92,133,147],"malignant":[93,134],"lymphomas,":[94],"four":[96],"centroblastic-centrocytic":[99],"lymphomas":[103],"located":[104],"mediastinum.":[107],"Surprisingly,":[108],"occurrence":[110],"highest":[116],"those":[118],"tumours,":[119,148],"where":[120],"low,":[124],"i.e.":[125],"subjects":[127],"mediastinal":[129],"However,":[136],"exception":[139],"abdomen":[145],"positive":[153],"individuals":[154],"comparable":[158],"part":[164],"healthy":[166]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}