{"id":"https://openalex.org/W2435672172","doi":"https://doi.org/10.1002/bit.26029","title":"Newly identified bacteriolytic enzymes that target a wide range of clinical isolates of Clostridium difficile","display_name":"Newly identified bacteriolytic enzymes that target a wide range of clinical isolates of Clostridium difficile","publication_year":2016,"publication_date":"2016-06-04","ids":{"openalex":"https://openalex.org/W2435672172","doi":"https://doi.org/10.1002/bit.26029","mag":"2435672172","pmid":"https://pubmed.ncbi.nlm.nih.gov/27260850","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5367918"},"language":"en","primary_location":{"id":"doi:10.1002/bit.26029","doi":"https://doi.org/10.1002/bit.26029","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bit.26029","pdf_url":null,"source":{"id":"https://openalex.org/S151564723","display_name":"Biotechnology and Bioengineering","issn_l":"0006-3592","issn":["0006-3592","1097-0290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Bioengineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5367918","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021799703","display_name":"Krunal K. Mehta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krunal K. Mehta","raw_affiliation_strings":["Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, 12180 New York","Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, 12180 New York","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041014877","display_name":"Elena E. Paskaleva","orcid":"https://orcid.org/0000-0002-4291-9969","observed_orcids":["https://orcid.org/0000-0002-4291-9969"]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena E. Paskaleva","raw_affiliation_strings":["Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, 12180 New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, 12180 New York","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008533558","display_name":"Xia Wu","orcid":"https://orcid.org/0000-0002-4161-6552","observed_orcids":["https://orcid.org/0000-0002-4161-6552"]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xia Wu","raw_affiliation_strings":["Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, 12180 New York","Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, 12180 New York","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052409774","display_name":"Navdeep Grover","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navdeep Grover","raw_affiliation_strings":["Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, 12180 New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, 12180 New York","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031820378","display_name":"Ruchir V. Mundra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruchir V. Mundra","raw_affiliation_strings":["Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, 12180 New York","Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, 12180 New York","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100350896","display_name":"Kevin Chen","orcid":"https://orcid.org/0000-0002-5120-6119","observed_orcids":["https://orcid.org/0000-0002-5120-6119"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Chen","raw_affiliation_strings":["Department of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019190652","display_name":"Yongrong Zhang","orcid":"https://orcid.org/0000-0002-8594-4232","observed_orcids":["https://orcid.org/0000-0002-8594-4232"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yongrong Zhang","raw_affiliation_strings":["Department of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038427328","display_name":"Zhiyong Yang","orcid":"https://orcid.org/0000-0003-0589-6224","observed_orcids":["https://orcid.org/0000-0003-0589-6224"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiyong Yang","raw_affiliation_strings":["Department of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068598326","display_name":"Hanping Feng","orcid":"https://orcid.org/0000-0002-8685-1812","observed_orcids":["https://orcid.org/0000-0002-8685-1812"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanping Feng","raw_affiliation_strings":["Department of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043598718","display_name":"Jonathan S. Dordick","orcid":"https://orcid.org/0000-0001-7802-3702","observed_orcids":["https://orcid.org/0000-0001-7802-3702"]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan S. Dordick","raw_affiliation_strings":["Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, 12180 New York","Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, 12180 New York","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003357270","display_name":"Ravi S. Kane","orcid":"https://orcid.org/0000-0003-3084-4098","observed_orcids":["https://orcid.org/0000-0003-3084-4098"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ravi S. Kane","raw_affiliation_strings":["School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 950 Atlantic Drive, Atlanta, 30332 Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 950 Atlantic Drive, Atlanta, 30332 Georgia","institution_ids":["https://openalex.org/I130701444"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003357270","https://openalex.org/A5043598718"],"corresponding_institution_ids":["https://openalex.org/I130701444","https://openalex.org/I165799507"],"apc_list":{"value":5060,"currency":"USD","value_usd":5060},"apc_paid":null,"fwci":1.7453,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.8367142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"113","issue":"12","first_page":"2568","last_page":"2576"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.6265000104904175,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.6265000104904175,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.36399999260902405,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clostridioides-difficile","display_name":"Clostridium difficile","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bacteriolytic-enzymes","display_name":"bacteriolytic enzymes","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cell-wall-lytic-enzymes","display_name":"cell wall lytic enzymes","score":0.7699999809265137},{"id":"https://openalex.org/keywords/peptidoglycan-cleavage","display_name":"peptidoglycan cleavage","score":0.843999981880188},{"id":"https://openalex.org/keywords/phage-encoded-enzymes","display_name":"phage-encoded enzymes","score":0.515999972820282},{"id":"https://openalex.org/keywords/clostridium-difficile-infection","display_name":"Clostridium difficile infection","score":0.675000011920929},{"id":"https://openalex.org/keywords/antibiotic-associated-diarrhea","display_name":"antibiotic-associated diarrhea","score":0.652999997138977},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.5600000023841858},{"id":"https://openalex.org/keywords/phage-therapy","display_name":"phage therapy","score":0.40400001406669617}],"concepts":[{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.868651807308197},{"id":"https://openalex.org/C2994496256","wikidata":"https://www.wikidata.org/wiki/Q27031090","display_name":"Clostridium difficile","level":3,"score":0.8324100971221924},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6966441869735718},{"id":"https://openalex.org/C2776634448","wikidata":"https://www.wikidata.org/wiki/Q206920","display_name":"Peptidoglycan","level":3,"score":0.6862587332725525},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6483502388000488},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5911614298820496},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5581950545310974},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4646430015563965},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37834179401397705},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.36033451557159424},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3035336136817932},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.24445617198944092},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10596397519111633},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.05926251411437988}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001433","descriptor_name":"Bacteriolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001433","descriptor_name":"Bacteriolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016360","descriptor_name":"Clostridioides difficile","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016360","descriptor_name":"Clostridioides difficile","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016360","descriptor_name":"Clostridioides difficile","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/bit.26029","doi":"https://doi.org/10.1002/bit.26029","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bit.26029","pdf_url":null,"source":{"id":"https://openalex.org/S151564723","display_name":"Biotechnology and Bioengineering","issn_l":"0006-3592","issn":["0006-3592","1097-0290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Bioengineering","raw_type":"journal-article"},{"id":"pmid:27260850","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27260850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and bioengineering","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4215609","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5367918","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5367918","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5367918","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biotechnol Bioeng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4215609","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5367918","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2842300360","display_name":null,"funder_award_id":"W9132T\u201011\u2010C\u20100025","funder_id":"https://openalex.org/F4320332186","funder_display_name":"Defense Threat Reduction Agency"},{"id":"https://openalex.org/G2990970294","display_name":"Epithelium, dendritic cells, and Clostridium difficile associated colitis","funder_award_id":"R01DK084509","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7320980251","display_name":"Development of Vaccines against Clostridium difficile Infection","funder_award_id":"R01AI088748","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G761247846","display_name":"Immunoprophylactic Strategies to Control Emerging Enteric Infections","funder_award_id":"U19AI109776","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332186","display_name":"Defense Threat Reduction Agency","ror":"https://ror.org/04tz64554"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1531679989","https://openalex.org/W1969128912","https://openalex.org/W1970532969","https://openalex.org/W1979671672","https://openalex.org/W1982816139","https://openalex.org/W1993031384","https://openalex.org/W2004589024","https://openalex.org/W2012464397","https://openalex.org/W2024222516","https://openalex.org/W2026948425","https://openalex.org/W2027854362","https://openalex.org/W2034346270","https://openalex.org/W2035333716","https://openalex.org/W2036996222","https://openalex.org/W2037993016","https://openalex.org/W2041613596","https://openalex.org/W2042217887","https://openalex.org/W2044219362","https://openalex.org/W2061113012","https://openalex.org/W2063524891","https://openalex.org/W2064573072","https://openalex.org/W2071054182","https://openalex.org/W2078358739","https://openalex.org/W2083941290","https://openalex.org/W2093917326","https://openalex.org/W2101233913","https://openalex.org/W2104928240","https://openalex.org/W2106350361","https://openalex.org/W2108649941","https://openalex.org/W2108670255","https://openalex.org/W2114644887","https://openalex.org/W2115583334","https://openalex.org/W2119225291","https://openalex.org/W2124370201","https://openalex.org/W2127385500","https://openalex.org/W2128903629","https://openalex.org/W2130641564","https://openalex.org/W2133116674","https://openalex.org/W2149177254","https://openalex.org/W2151532303","https://openalex.org/W2153544371","https://openalex.org/W2156408202","https://openalex.org/W2159332480","https://openalex.org/W2161501189","https://openalex.org/W2163423623","https://openalex.org/W2166428376","https://openalex.org/W2166602148","https://openalex.org/W2318911370","https://openalex.org/W2331725203"],"related_works":["https://openalex.org/W4244349693","https://openalex.org/W3139510258","https://openalex.org/W4282838993","https://openalex.org/W4414242691","https://openalex.org/W4292548628","https://openalex.org/W2150255161","https://openalex.org/W4413406519","https://openalex.org/W7220716200","https://openalex.org/W2127385500","https://openalex.org/W4388038558"],"abstract_inverted_index":{"Clostridium":[0],"difficile":[1,27,162,200,238],"has":[2],"emerged":[3],"as":[4,62,98,109,111],"a":[5,73,78,82,135,165,170,195,226],"major":[6],"cause":[7],"of":[8,34,77,106,178,184,198],"infectious":[9],"diarrhea":[10],"in":[11,102,134,149,164,175],"hospitalized":[12],"patients,":[13],"with":[14,31,124,236],"increasing":[15],"mortality":[16],"rate":[17],"and":[18,58,65,81,93,140,145],"annual":[19],"healthcare":[20,233],"costs":[21],"exceeding":[22],"$3":[23],"billion.":[24],"Since":[25],"C.":[26,107,114,128,161,199,237],"infections":[28],"are":[29],"associated":[30,235],"the":[32,47,86,104,132,142,176,190,206,211,219,231],"use":[33],"antibiotics,":[35],"there":[36],"is":[37],"an":[38],"urgent":[39],"need":[40],"to":[41,157,229],"develop":[42],"treatments":[43],"that":[44,189],"can":[45],"inactivate":[46],"bacterium":[48],"selectively":[49],"without":[50],"affecting":[51],"commensal":[52],"microflora.":[53],"Lytic":[54],"enzymes":[55,70,123,154,191,217],"from":[56],"bacteria":[57,180],"bacteriophages":[59],"show":[60],"promise":[61],"highly":[63],"selective":[64],"effective":[66],"antimicrobial":[67],"agents.":[68],"These":[69,151,223],"often":[71],"have":[72],"modular":[74],"structure,":[75],"consisting":[76],"catalytic":[79,91],"domain":[80,92,96],"binding":[83,95],"domain.":[84],"In":[85],"current":[87],"work,":[88],"using":[89],"consensus":[90],"cell-wall":[94],"sequences":[97],"probes,":[99],"we":[100,187],"analyzed":[101],"silico":[103],"genome":[105],"difficile,":[108],"well":[110],"phages":[112],"infecting":[113],"difficile.":[115,129],"We":[116,130,168,203],"identified":[117,153],"two":[118],"genes":[119,133],"encoding":[120],"cell":[121,220],"lytic":[122],"possible":[125],"activity":[126,148],"against":[127,160,194],"cloned":[131],"suitable":[136],"expression":[137],"vector,":[138],"expressed":[139],"purified":[141],"protein":[143],"products,":[144],"tested":[146],"enzyme":[147],"vitro.":[150],"newly":[152],"were":[155,192],"found":[156,188],"be":[158],"active":[159,193],"cells":[163],"dose-dependent":[166],"manner.":[167],"achieved":[169],"more":[171],"than":[172],"4-log":[173],"reduction":[174],"number":[177],"viable":[179],"within":[181,218],"5":[182],"h":[183],"application.":[185],"Moreover,":[186],"wide":[196],"range":[197],"clinical":[201],"isolates.":[202],"also":[204],"characterized":[205],"biocatalytic":[207],"mechanism":[208],"by":[209,215],"identifying":[210],"specific":[212],"bonds":[213],"cleaved":[214],"these":[216],"wall":[221],"peptidoglycan.":[222],"results":[224],"suggest":[225],"new":[227],"approach":[228],"combating":[230],"growing":[232],"problem":[234],"infections.":[239],"Biotechnol.":[240],"Bioeng.":[241],"2016;113:":[242],"2568-2576.":[243],"\u00a9":[244],"2016":[245],"Wiley":[246],"Periodicals,":[247],"Inc.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
