{"id":"https://openalex.org/W24350975","doi":null,"title":"[The expression of cMET/hepatocyte growth factor receptor in colorectal cancer].","display_name":"[The expression of cMET/hepatocyte growth factor receptor in colorectal cancer].","publication_year":1998,"publication_date":"1998-07-01","ids":{"openalex":"https://openalex.org/W24350975","mag":"24350975","pmid":"https://pubmed.ncbi.nlm.nih.gov/9721515"},"language":"ja","primary_location":{"id":"pmid:9721515","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9721515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014887114","display_name":"Hideyuki Ajisaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Ajisaka","raw_affiliation_strings":["Second Department of Surgery, Kanazawa University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Surgery, Kanazawa University School of Medicine","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":null,"display_name":"G Nishimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Nishimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029575181","display_name":"Atsushi Tsuneda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Tsuneda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113260114","display_name":"Hironori Fujita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Fujita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079463857","display_name":"Yoshio Michiwa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Michiwa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Kawamura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Kawamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050932546","display_name":"Taisuke Sato","orcid":"https://orcid.org/0000-0001-6609-9179","observed_orcids":["https://orcid.org/0000-0001-6609-9179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Sato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072466530","display_name":"Naomi Nojima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Nojima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024644803","display_name":"Sachio Fushida","orcid":"https://orcid.org/0000-0001-5567-7383","observed_orcids":["https://orcid.org/0000-0001-5567-7383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Fushida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110040845","display_name":"Tsuyoshi Fujimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Fujimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049886032","display_name":"Yutaka Yonemura","orcid":"https://orcid.org/0000-0002-2458-4106","observed_orcids":["https://orcid.org/0000-0002-2458-4106"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Yonemura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112715023","display_name":"K Miwa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Miwa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.00237854,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"95","issue":"7","first_page":"750","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.9980000257492065},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.953000009059906},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/peritoneal-metastases","display_name":"peritoneal carcinomatosis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/lymphatic-vessel-invasion","display_name":"lymphatic vessel invasion","score":0.7990000247955322},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.7920252084732056},{"id":"https://openalex.org/C2910739307","wikidata":"https://www.wikidata.org/wiki/Q5005897","display_name":"Hepatocyte Growth Factor Receptor","level":5,"score":0.7661185264587402},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7394683361053467},{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.7114211320877075},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.6402361392974854},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6191139817237854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6172573566436768},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5890133380889893},{"id":"https://openalex.org/C2780467284","wikidata":"https://www.wikidata.org/wiki/Q5005897","display_name":"C-Met","level":4,"score":0.4797283709049225},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.4688996374607086},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44458526372909546},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4415217936038971},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4348568916320801},{"id":"https://openalex.org/C2992571226","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node metastasis","level":4,"score":0.4252329468727112},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4208299219608307},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2764381170272827},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9721515","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9721515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology","raw_type":"English Abstract"},{"id":"mag:24350975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9721515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W2017321847","https://openalex.org/W2393219434","https://openalex.org/W2118992568","https://openalex.org/W2107254035","https://openalex.org/W2057265095","https://openalex.org/W2157243339","https://openalex.org/W2065384164","https://openalex.org/W1987172422","https://openalex.org/W1997800332","https://openalex.org/W2093676252","https://openalex.org/W1998159103","https://openalex.org/W2159988048","https://openalex.org/W2064484958","https://openalex.org/W2103771013","https://openalex.org/W2149216059","https://openalex.org/W1999969457","https://openalex.org/W2008019573","https://openalex.org/W2042335480","https://openalex.org/W2127837438","https://openalex.org/W2018343808","https://openalex.org/W2010780461","https://openalex.org/W2035889417","https://openalex.org/W2087399526","https://openalex.org/W2126547777","https://openalex.org/W2161151481","https://openalex.org/W1907042839","https://openalex.org/W1491518420","https://openalex.org/W2088344246","https://openalex.org/W1996393308","https://openalex.org/W1993066796","https://openalex.org/W2100363885","https://openalex.org/W2003470472","https://openalex.org/W2091361530","https://openalex.org/W2132145612","https://openalex.org/W1990497976","https://openalex.org/W984428934","https://openalex.org/W2109586110","https://openalex.org/W2098346352","https://openalex.org/W2000275267","https://openalex.org/W1490961634","https://openalex.org/W2160795579","https://openalex.org/W2105330971"],"related_works":["https://openalex.org/W2364702362","https://openalex.org/W6907775072","https://openalex.org/W2389459790","https://openalex.org/W2292564567","https://openalex.org/W2357279738","https://openalex.org/W2056331663","https://openalex.org/W2360247035","https://openalex.org/W2152867978","https://openalex.org/W2413026171","https://openalex.org/W2396219473"],"abstract_inverted_index":{"In":[0,17],"this":[1],"study,":[2],"we":[3],"estimated":[4],"the":[5,28,33,38,69,75,80,114,124,143],"expression":[6],"of":[7,31,35,72,77,110,147],"c-MET/Hepatocyte":[8],"Growth":[9],"Factor":[10],"receptor":[11],"in":[12,23,37,79,142],"colorectal":[13,148],"cancers":[14],"by":[15],"immunohistochemistry.":[16],"118":[18],"patients,":[19],"c-MET":[20,136],"wee":[21],"expressed":[22],"65":[24],"patients":[25,39,81],"(55%).":[26],"About":[27,68],"clinicopathological":[29],"findings":[30,71],"metastasis,":[32,42,52],"proportion":[34,76,109],"c-MET-positive":[36,78,111],"with":[40,82],"liver":[41,51],"78%":[43],"(18/23),":[44],"was":[45,57,89,100],"significantly":[46,90],"higher":[47,91],"than":[48,92],"that":[49,93,135],"without":[50,94],"49%":[53],"(47/95),":[54],"but":[55,98],"there":[56,99],"no":[58,101],"significant":[59,102],"difference":[60,103],"about":[61,104],"lymph":[62],"node":[63],"metastasis":[64],"and":[65,122,145],"peritoneal":[66],"dissemination.":[67],"pathological":[70],"primary":[73],"lesion,":[74],"infiltration":[83,105],"into":[84,106],"lymphatic":[85],"vessels,":[86],"63%":[87],"(48/76),":[88],"infiltration,":[95],"40%":[96],"(17/42),":[97],"veins.":[107],"The":[108],"increased":[112],"as":[113,123],"tumor":[115],"stage":[116,126],"proceeded":[117,127],"from":[118,128],"t1":[119],"to":[120,130],"t4":[121],"histopathological":[125],"I":[129],"IV.":[131],"These":[132],"results":[133],"suggest":[134],"may":[137],"play":[138],"an":[139],"important":[140],"role":[141],"growth":[144],"scattering":[146],"cancer":[149],"cells.":[150]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}