{"id":"https://openalex.org/W2434567203","doi":"https://doi.org/10.1158/1078-0432.ccr-16-1108","title":"Checkpoint Inhibition of KIR2D with the Monoclonal Antibody IPH2101 Induces Contraction and Hyporesponsiveness of NK Cells in Patients with Myeloma","display_name":"Checkpoint Inhibition of KIR2D with the Monoclonal Antibody IPH2101 Induces Contraction and Hyporesponsiveness of NK Cells in Patients with Myeloma","publication_year":2016,"publication_date":"2016-06-16","ids":{"openalex":"https://openalex.org/W2434567203","doi":"https://doi.org/10.1158/1078-0432.ccr-16-1108","mag":"2434567203","pmid":"https://pubmed.ncbi.nlm.nih.gov/27307594","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8638787"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-16-1108","doi":"https://doi.org/10.1158/1078-0432.ccr-16-1108","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-16-1108","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8638787","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068405803","display_name":"Mattias Carlsten","orcid":"https://orcid.org/0000-0001-9815-0012","observed_orcids":["https://orcid.org/0000-0001-9815-0012"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mattias Carlsten","raw_affiliation_strings":["1Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062086023","display_name":"Neha Korde","orcid":"https://orcid.org/0000-0002-5538-4318","observed_orcids":["https://orcid.org/0000-0002-5538-4318","https://orcid.org/0009-0008-6054-193X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neha Korde","raw_affiliation_strings":["2Metabolism Branch, NCI, NIH, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Metabolism Branch, NCI, NIH, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019538697","display_name":"Ritesh R. Kotecha","orcid":"https://orcid.org/0000-0002-0223-3479","observed_orcids":["https://orcid.org/0000-0002-0223-3479"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ritesh Kotecha","raw_affiliation_strings":["1Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087705062","display_name":"Robert N. Reger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Reger","raw_affiliation_strings":["1Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054865577","display_name":"Simona Bor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simona Bor","raw_affiliation_strings":["1Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048966043","display_name":"Dickran Gano Kazandjian","orcid":"https://orcid.org/0000-0002-6593-0917","observed_orcids":["https://orcid.org/0000-0002-6593-0917"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dickran Kazandjian","raw_affiliation_strings":["2Metabolism Branch, NCI, NIH, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Metabolism Branch, NCI, NIH, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082004555","display_name":"Ola Landgren","orcid":"https://orcid.org/0000-0001-6485-4839","observed_orcids":["https://orcid.org/0000-0001-6485-4839"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ola Landgren","raw_affiliation_strings":["2Metabolism Branch, NCI, NIH, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Metabolism Branch, NCI, NIH, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112507028","display_name":"Richard W. Childs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard W. Childs","raw_affiliation_strings":["1Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112507028"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"],"apc_list":null,"apc_paid":null,"fwci":11.7133,"has_fulltext":false,"cited_by_count":166,"citation_normalized_percentile":{"value":0.98916141,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"22","issue":"21","first_page":"5211","last_page":"5222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.7900000214576721},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7549999952316284},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.8489999771118164},{"id":"https://openalex.org/keywords/smoldering-multiple-myeloma","display_name":"smoldering multiple myeloma","score":0.8730000257492065},{"id":"https://openalex.org/keywords/trogocytosis","display_name":"trogocytosis","score":0.953000009059906},{"id":"https://openalex.org/keywords/kir-ligand-mismatch","display_name":"KIR ligand mismatch","score":0.9380000233650208},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.7160000205039978},{"id":"https://openalex.org/keywords/monoclonal-antibody-therapy","display_name":"monoclonal antibody therapy","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.576880693435669},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5083567500114441},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5016121864318848},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4965677857398987},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.49537932872772217},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4872097373008728},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46200627088546753},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43695637583732605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37416455149650574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3315325975418091}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D054340","descriptor_name":"Receptors, KIR","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.ccr-16-1108","doi":"https://doi.org/10.1158/1078-0432.ccr-16-1108","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-16-1108","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:27307594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27307594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:pubmedcentral.nih.gov:8638787","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8638787","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8638787","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8638787","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G4826795830","display_name":"Allogeneic Immunotherapy for cancer and nonmalignant hematological disorders","funder_award_id":"Z01HL002345","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000911217","display_name":"Allogeneic and Autologous Immunotherapy for cancer and nonmalignant hematological disorders","funder_award_id":"ZIAHL002345","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320338421","display_name":"NHLBI Division of Intramural Research","ror":"https://ror.org/023ny1p48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W5193816","https://openalex.org/W1538460158","https://openalex.org/W1599718730","https://openalex.org/W1610114835","https://openalex.org/W1612595544","https://openalex.org/W1756275312","https://openalex.org/W1838155222","https://openalex.org/W1885961362","https://openalex.org/W1974475667","https://openalex.org/W1978651681","https://openalex.org/W1989712520","https://openalex.org/W1994182910","https://openalex.org/W1995224930","https://openalex.org/W2002927100","https://openalex.org/W2005765588","https://openalex.org/W2015517794","https://openalex.org/W2017651916","https://openalex.org/W2018580749","https://openalex.org/W2018922991","https://openalex.org/W2023082289","https://openalex.org/W2025838903","https://openalex.org/W2026462640","https://openalex.org/W2036557347","https://openalex.org/W2039638023","https://openalex.org/W2054047951","https://openalex.org/W2059229059","https://openalex.org/W2060070314","https://openalex.org/W2062737455","https://openalex.org/W2068176895","https://openalex.org/W2086785453","https://openalex.org/W2087580642","https://openalex.org/W2088513299","https://openalex.org/W2090083883","https://openalex.org/W2099116621","https://openalex.org/W2109176206","https://openalex.org/W2122786380","https://openalex.org/W2147068163","https://openalex.org/W2160689454","https://openalex.org/W2165144791","https://openalex.org/W2165635676","https://openalex.org/W2165813814","https://openalex.org/W2168780924","https://openalex.org/W2410791612","https://openalex.org/W4250776648","https://openalex.org/W6714633699"],"related_works":["https://openalex.org/W1995224930","https://openalex.org/W2477314148","https://openalex.org/W2018580749","https://openalex.org/W2593329459","https://openalex.org/W2300424973","https://openalex.org/W2591239798","https://openalex.org/W2565285003","https://openalex.org/W2090083883","https://openalex.org/W2577603394","https://openalex.org/W2980193795"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Immune":[2],"checkpoint":[3,41,265],"inhibitors":[4],"have":[5,38],"recently":[6],"revolutionized":[7],"cancer":[8],"immunotherapy.":[9],"On":[10],"the":[11,23,55,93,97,139,175,188,215,224,245],"basis":[12],"of":[13,25,85,99,110,160,190,206,218,235],"data":[14,241],"showing":[15],"KIR-ligand":[16,60],"mismatched":[17,61],"natural":[18],"killer":[19],"(NK)":[20],"cells":[21,193],"reduce":[22],"risk":[24],"leukemia":[26],"and":[27,128,142,149,171,232,279],"multiple":[28,77],"myeloma":[29,78],"relapse":[30],"following":[31],"allogeneic":[32],"hematopoietic":[33],"stem":[34],"cell":[35,147,169,177,200,261],"transplantation,":[36],"investigators":[37],"developed":[39],"a":[40,120],"inhibition":[42],"antibody":[43,57],"that":[44,244],"blocks":[45],"KIR":[46],"on":[47,174],"NK":[48,65,146,168,176,192,199,222,237,260],"cells.":[49,238],"Although":[50,211],"in":[51,73,163,166,198,250],"vitro":[52,180],"studies":[53],"suggest":[54],"KIR2D-specific":[56],"IPH2101":[58,113,161,212],"induces":[59],"tumor":[62,262],"killing":[63,263],"by":[64,135,194,229,277],"cells,":[66,223],"our":[67],"single-arm":[68],"phase":[69],"II":[70],"clinical":[71,86,100],"trial":[72],"patients":[74,105],"with":[75,196,204],"smoldering":[76],"was":[79,124,151,227],"prematurely":[80],"terminated":[81],"due":[82],"to":[83,119],"lack":[84,98],"efficacy.":[87,101],"This":[88],"study":[89,252],"aimed":[90],"at":[91,126,258],"unveiling":[92],"underlying":[94],"mechanisms":[95],"behind":[96],"Experimental":[102],"Design:":[103],"Treatment-na\u00efve":[104],"received":[106],"an":[107],"intravenous":[108],"infusion":[109,159],"1":[111],"mg/kg":[112],"every":[114],"other":[115],"month":[116,141],"for":[117,138],"up":[118],"year.":[121],"Peripheral":[122],"blood":[123],"collected":[125],"baseline":[127],"24":[129],"hours":[130],"after":[131],"first":[132,140],"infusion,":[133],"followed":[134],"weekly":[136],"samples":[137,144],"monthly":[143],"thereafter.":[145],"phenotype":[148],"function":[150,201,234],"analyzed":[152],"using":[153],"high-resolution":[154],"flow":[155],"cytometry.":[156],"Results:":[157],"Unexpectedly,":[158],"resulted":[162],"rapid":[164],"reduction":[165],"both":[167],"responsiveness":[170],"KIR2D":[172,183,208],"expression":[173],"surface.":[178],"In":[179],"assays":[181],"revealed":[182],"molecules":[184],"are":[185],"removed":[186],"from":[187],"surface":[189,209],"IPH2101-treated":[191],"trogocytosis,":[195],"reductions":[197],"directly":[202],"correlating":[203],"loss":[205],"free":[207],"molecules.":[210],"marginally":[213],"augmented":[214],"antimyeloma":[216],"cytotoxicity":[217],"remaining":[219],"KIR2Ddull":[220],"patient":[221],"overall":[225],"response":[226],"diminished":[228],"significant":[230],"contraction":[231],"reduced":[233],"KIR2D-expressing":[236],"Conclusions:":[239],"These":[240],"raise":[242],"concerns":[243],"unexpected":[246],"biological":[247],"events":[248],"reported":[249],"this":[251],"could":[253],"compromise":[254],"antibody-based":[255],"strategies":[256],"designed":[257],"augmenting":[259],"via":[264],"inhibition.":[266],"Clin":[267],"Cancer":[268],"Res;":[269],"22(21);":[270],"5211\u201322.":[271],"\u00a92016":[272],"AACR.":[273],"See":[274],"related":[275],"commentary":[276],"Felices":[278],"Miller,":[280],"p.":[281],"5161":[282]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":25},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
