{"id":"https://openalex.org/W2434476543","doi":null,"title":"Benefit/risk of therapies for rheumatoid arthritis: underestimation of the \"side effects\" or risks of RA leads to underestimation of the benefit/risk of therapies.","display_name":"Benefit/risk of therapies for rheumatoid arthritis: underestimation of the \"side effects\" or risks of RA leads to underestimation of the benefit/risk of therapies.","publication_year":2004,"publication_date":"2004-09-01","ids":{"openalex":"https://openalex.org/W2434476543","mag":"2434476543","pmid":"https://pubmed.ncbi.nlm.nih.gov/15552508"},"language":"en","primary_location":{"id":"pmid:15552508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15552508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064101830","display_name":"Theodore Pincus","orcid":"https://orcid.org/0000-0002-8998-8865","observed_orcids":["https://orcid.org/0000-0002-8998-8865"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Pincus","raw_affiliation_strings":["Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-4500, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-4500, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107413697","display_name":"Arthur Kavanaugh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Kavanaugh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065394113","display_name":"Tuulikki Sokka","orcid":"https://orcid.org/0000-0002-6972-5603","observed_orcids":["https://orcid.org/0000-0002-6972-5603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Sokka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.512,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.80122687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"5 Suppl 35","first_page":"S2","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/risk-benefit-assessment","display_name":"risk-benefit assessment","score":0.7760000228881836},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.5580000281333923},{"id":"https://openalex.org/keywords/long-term-outcomes","display_name":"long-term outcomes","score":0.6970000267028809},{"id":"https://openalex.org/keywords/aggressive-treatment","display_name":"aggressive treatment","score":0.4309999942779541},{"id":"https://openalex.org/keywords/disease-modifying-antirheumatic-drugs","display_name":"disease-modifying antirheumatic drugs","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9710371494293213},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.8027777671813965},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5784677267074585},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5496255159378052},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.5099979639053345},{"id":"https://openalex.org/C163276114","wikidata":"https://www.wikidata.org/wiki/Q484591","display_name":"Natural history","level":2,"score":0.5063761472702026},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5047522783279419},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4903755187988281},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4435533583164215},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.4158467650413513},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3398597240447998},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.18357965350151062},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15552508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15552508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"mag:2434476543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15552508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W1827246","https://openalex.org/W19408429","https://openalex.org/W34597846","https://openalex.org/W48703373","https://openalex.org/W60457073","https://openalex.org/W63460477","https://openalex.org/W84416910","https://openalex.org/W180408228","https://openalex.org/W337913884","https://openalex.org/W772669020","https://openalex.org/W1496359599","https://openalex.org/W1662891024","https://openalex.org/W1969234933","https://openalex.org/W1970046651","https://openalex.org/W1973470201","https://openalex.org/W1979207905","https://openalex.org/W1979364075","https://openalex.org/W1981207374","https://openalex.org/W1982493663","https://openalex.org/W1996472975","https://openalex.org/W2003268426","https://openalex.org/W2007496164","https://openalex.org/W2010461628","https://openalex.org/W2012703452","https://openalex.org/W2014433635","https://openalex.org/W2015515502","https://openalex.org/W2017473710","https://openalex.org/W2028579495","https://openalex.org/W2030499909","https://openalex.org/W2030682849","https://openalex.org/W2031543639","https://openalex.org/W2034401866","https://openalex.org/W2034716696","https://openalex.org/W2042458925","https://openalex.org/W2044163521","https://openalex.org/W2048860421","https://openalex.org/W2058804582","https://openalex.org/W2063217417","https://openalex.org/W2064630835","https://openalex.org/W2065843132","https://openalex.org/W2067257312","https://openalex.org/W2067257696","https://openalex.org/W2078317963","https://openalex.org/W2078835830","https://openalex.org/W2081773112","https://openalex.org/W2082945361","https://openalex.org/W2083673654","https://openalex.org/W2089389692","https://openalex.org/W2095427168","https://openalex.org/W2097564087","https://openalex.org/W2097924208","https://openalex.org/W2098293486","https://openalex.org/W2100763674","https://openalex.org/W2101596556","https://openalex.org/W2105764923","https://openalex.org/W2106952837","https://openalex.org/W2111540856","https://openalex.org/W2112753620","https://openalex.org/W2115004354","https://openalex.org/W2120953658","https://openalex.org/W2132697065","https://openalex.org/W2138586603","https://openalex.org/W2138796127","https://openalex.org/W2143967817","https://openalex.org/W2145756491","https://openalex.org/W2152348310","https://openalex.org/W2165584277","https://openalex.org/W2166165376","https://openalex.org/W2167505185","https://openalex.org/W2169354330","https://openalex.org/W2246854978","https://openalex.org/W2319957449","https://openalex.org/W2319983832","https://openalex.org/W2323424522","https://openalex.org/W2324841714","https://openalex.org/W2328587823","https://openalex.org/W2331320446","https://openalex.org/W2339418475","https://openalex.org/W2400374725","https://openalex.org/W2402241442","https://openalex.org/W2402862267","https://openalex.org/W2403553485","https://openalex.org/W2409808456","https://openalex.org/W2410291574","https://openalex.org/W2418841025","https://openalex.org/W2418970185","https://openalex.org/W2422729678","https://openalex.org/W2429428036","https://openalex.org/W2460195387","https://openalex.org/W2797368993"],"related_works":["https://openalex.org/W2042458925","https://openalex.org/W2945020545","https://openalex.org/W2418473734","https://openalex.org/W2011031966","https://openalex.org/W2151207112","https://openalex.org/W2997258889","https://openalex.org/W48375751","https://openalex.org/W2000546397","https://openalex.org/W1518744423","https://openalex.org/W2147355996"],"abstract_inverted_index":{"Most":[0],"physicians":[1],"are":[2,68,132,148],"familiar":[3,21],"with":[4,22,29,66,75,130,255],"the":[5,23,38,51,70,90,138,164,170,205,214,235,246,251],"side":[6],"effects":[7],"or":[8,26,45,53,79,120],"risks":[9,27,91],"of":[10,60,72,92,126,153,208,218,238],"drugs":[11],"used":[12],"to":[13,36,87,101,135,163,213,229],"treat":[14],"rheumatoid":[15],"arthritis":[16],"(RA),":[17],"but":[18],"relatively":[19],"less":[20],"\"side":[24],"effects\"":[25],"associated":[28],"RA":[30,32,67,93,97,116,131,209,241,256],"itself":[31],"is":[33,187,257],"not":[34,99,189],"thought":[35],"have":[37,94,107,117,143,221],"same":[39],"potential":[40],"severity":[41],"as":[42],"a":[43,118,151],"cardiovascular":[44],"neoplastic":[46],"disease":[47,78],"by":[48],"most":[49,110,179],"physicians,":[50],"public,":[52],"even":[54],"some":[55,64,73],"rheumatologists,":[56],"although":[57],"relative":[58],"rates":[59],"predicted":[61],"mortality":[62],"in":[63,69,128,137,191,204,264],"patients":[65,254],"range":[71],"people":[74,111,129],"coronary":[76],"artery":[77],"Hodgkin's":[80],"disease.":[81],"Many":[82],"reasons":[83],"may":[84],"be":[85],"identified":[86],"explain":[88],"why":[89],"been":[95,222],"underestimated:":[96],"does":[98],"lead":[100],"acute":[102,123],"life-threatening":[103],"situations;":[104],"population-based":[105],"data":[106],"suggested":[108,144,172],"that":[109,147,173,234],"who":[112],"meet":[113],"criteria":[114],"for":[115,178,240,253],"mild":[119],"self-limited":[121],"process;":[122],"attributed":[124],"causes":[125],"death":[127],"superficially":[133],"similar":[134],"those":[136],"general":[139],"population;":[140],"clinical":[141],"trials":[142],"many":[145],"therapies":[146,175,239],"efficacious":[149],"over":[150,245],"period":[152],"3-12":[154],"months;":[155],"few":[156],"long-term":[157,202],"longitudinal":[158],"studies":[159],"were":[160,176],"performed":[161],"prior":[162,212],"1980s;":[165],"medical":[166],"recommendations":[167],"made":[168],"during":[169],"1950s-1980s":[171],"simple":[174],"adequate":[177],"patients;":[180],"and":[181,250],"quantitative":[182],"information":[183,197],"concerning":[184,200],"patient":[185],"status":[186],"generally":[188],"included":[190],"standard":[192],"rheumatology":[193],"care.":[194],"As":[195],"more":[196],"has":[198,227,242],"emerged":[199],"severe":[201],"outcomes":[203],"\"natural":[206],"history\"":[207],"(as":[210],"treated":[211],"1990s),":[215],"new":[216,230],"strategies":[217],"aggressive":[219],"intervention":[220],"developed.":[223],"Furthermore,":[224],"basic":[225],"research":[226],"led":[228],"therapies.":[231],"It":[232],"appears":[233],"benefit/risk":[236],"ratio":[237],"increased":[243],"substantially":[244],"last":[247],"two":[248],"decades,":[249],"outlook":[252],"much":[258],"better":[259],"at":[260],"this":[261],"time":[262],"than":[263],"previous":[265],"years.":[266]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
