{"id":"https://openalex.org/W2434445134","doi":"https://doi.org/10.1182/blood.v83.12.3473.3473","title":"Phase I study of recombinant interleukin-1 beta in patients undergoing autologous bone marrow transplant for acute myelogenous leukemia","display_name":"Phase I study of recombinant interleukin-1 beta in patients undergoing autologous bone marrow transplant for acute myelogenous leukemia","publication_year":1994,"publication_date":"1994-06-15","ids":{"openalex":"https://openalex.org/W2434445134","doi":"https://doi.org/10.1182/blood.v83.12.3473.3473","mag":"2434445134","pmid":"https://pubmed.ncbi.nlm.nih.gov/8204876"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v83.12.3473.3473","doi":"https://doi.org/10.1182/blood.v83.12.3473.3473","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v83.12.3473.3473","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055054082","display_name":"John J. Nemunaitis","orcid":"https://orcid.org/0000-0002-2234-2381","observed_orcids":["https://orcid.org/0000-0002-2234-2381"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Nemunaitis","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056405520","display_name":"Frederick R. Appelbaum","orcid":"https://orcid.org/0000-0002-1839-5069","observed_orcids":["https://orcid.org/0000-0002-1839-5069"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"FR Appelbaum","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089559352","display_name":"Kathy Lilleby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Lilleby","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049843811","display_name":"Buhles Wc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WC Buhles","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112823148","display_name":"Craig S. Rosenfeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Rosenfeld","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014152289","display_name":"ZR Zeigler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ZR Zeigler","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113799171","display_name":"RK Shadduck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RK Shadduck","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071375525","display_name":"Jack W. Singer","orcid":"https://orcid.org/0000-0003-4001-4549","observed_orcids":["https://orcid.org/0000-0003-4001-4549"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JW Singer","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013494474","display_name":"William H. Meyer","orcid":"https://orcid.org/0000-0002-5981-3394","observed_orcids":["https://orcid.org/0000-0002-5981-3394"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W Meyer","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110892853","display_name":"C. Dean Buckner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CD Buckner","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210089486"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":3.5769,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.93688027,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"83","issue":"12","first_page":"3473","last_page":"3479"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.29739999771118164,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9039999842643738},{"id":"https://openalex.org/keywords/autologous-bone-marrow-transplantation","display_name":"autologous bone marrow transplantation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/colony-stimulating-factors","display_name":"colony-stimulating factors","score":0.8009999990463257},{"id":"https://openalex.org/keywords/neutrophil-recovery","display_name":"neutrophil recovery","score":0.7070000171661377},{"id":"https://openalex.org/keywords/infection-control","display_name":"infection control","score":0.5920000076293945},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.8610000014305115},{"id":"https://openalex.org/keywords/fever","display_name":"fever","score":0.5529999732971191},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.7879999876022339},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9051535129547119},{"id":"https://openalex.org/C2778594517","wikidata":"https://www.wikidata.org/wiki/Q2260058","display_name":"Chills","level":2,"score":0.8224491477012634},{"id":"https://openalex.org/C74133956","wikidata":"https://www.wikidata.org/wiki/Q4669824","display_name":"Absolute neutrophil count","level":4,"score":0.5915706753730774},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4980940818786621},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.48510754108428955},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4740419387817383},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.44415482878685},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4396117925643921},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4220935106277466},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4214118421077728},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.42131441831588745},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.41428709030151367},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.2945268154144287}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v83.12.3473.3473","doi":"https://doi.org/10.1182/blood.v83.12.3473.3473","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v83.12.3473.3473","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v83.12.3473.bloodjournal83123473","doi":"https://doi.org/10.1182/blood.v83.12.3473.bloodjournal83123473","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v83.12.3473.bloodjournal83123473","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:8204876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8204876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W144873728","https://openalex.org/W200860116","https://openalex.org/W241455346","https://openalex.org/W294231234","https://openalex.org/W305838808","https://openalex.org/W317817448","https://openalex.org/W1486523175","https://openalex.org/W1499511373","https://openalex.org/W1534274816","https://openalex.org/W1559603433","https://openalex.org/W1575925035","https://openalex.org/W1594253455","https://openalex.org/W1608312654","https://openalex.org/W1787132848","https://openalex.org/W1848552725","https://openalex.org/W1907786214","https://openalex.org/W1917704232","https://openalex.org/W1955596284","https://openalex.org/W1969454335","https://openalex.org/W1978417778","https://openalex.org/W1993194389","https://openalex.org/W1997752389","https://openalex.org/W2024365580","https://openalex.org/W2030530843","https://openalex.org/W2034432392","https://openalex.org/W2049423476","https://openalex.org/W2052264823","https://openalex.org/W2068021117","https://openalex.org/W2083801528","https://openalex.org/W2084378947","https://openalex.org/W2096205803","https://openalex.org/W2133410753","https://openalex.org/W2142782671","https://openalex.org/W2227468111","https://openalex.org/W2339392195","https://openalex.org/W2341557816","https://openalex.org/W2398604372","https://openalex.org/W2399069718","https://openalex.org/W2401081924","https://openalex.org/W2405878472","https://openalex.org/W2477069154","https://openalex.org/W2593892363","https://openalex.org/W4254175543"],"related_works":["https://openalex.org/W82465412","https://openalex.org/W2312764489","https://openalex.org/W2410601251","https://openalex.org/W1988844881","https://openalex.org/W1674635436","https://openalex.org/W252634188","https://openalex.org/W2001284308","https://openalex.org/W2014738190","https://openalex.org/W2077163532","https://openalex.org/W2343381302"],"abstract_inverted_index":{"A":[0,60,128],"phase":[1],"I":[2],"trial":[3],"was":[4,27,92,114,147,176,245],"conducted":[5],"with":[6,75,192,240],"recombinant":[7],"human":[8],"interleukin-1":[9],"beta":[10,26,175,238,266],"(rhIL-1":[11],"beta)":[12],"in":[13,94,116,170,179,220],"patients":[14,64,82,99,120,133,171,181,228,234,244],"undergoing":[15],"autologous":[16],"bone":[17],"marrow":[18],"(BM)":[19],"transplantation":[20],"for":[21,54,140],"acute":[22],"myelogenous":[23],"leukemia.":[24],"rhIL-1":[25,110,174,237,265],"administered":[28],"at":[29,149,258],"3":[30],"dose":[31,145,153],"levels":[32],"(0.01,":[33],"0.02,":[34],"0.05":[35,151],"microgram/kg)":[36],"by":[37],"30":[38,105],"minute":[39],"intravenous":[40],"infusion":[41,51,205],"once":[42],"a":[43,55,193],"day":[44,48],"beginning":[45],"on":[46,67],"the":[47,68,126,150,221,259],"of":[49,57,62,77,109,118,130,132,142,157,196,233,242,261],"BM":[50,204],"and":[52,70,102,112,201,218,229],"continuing":[53],"total":[56,61,129],"5":[58,121],"doses.":[59],"17":[63,98,119],"were":[65,73,223,256],"entered":[66],"trial,":[69],"their":[71],"results":[72],"compared":[74,239],"those":[76],"74":[78],"consecutive":[79],"historical":[80,180,230,243],"control":[81],"that":[83,241],"did":[84],"not":[85,224],"receive":[86],"colony":[87],"stimulating":[88],"factors.":[89],"Moderate":[90],"toxicity":[91,263],"observed":[93,115],"all":[95],"patients.":[96],"All":[97],"developed":[100],"fever":[101],"chills":[103],"within":[104],"minutes":[106],"after":[107,125,203],"initiation":[108],"beta,":[111],"hypotension":[113],"14":[117],"to":[122,160,190],"8":[123],"hours":[124],"infusion.":[127],"30%":[131],"required":[134,159],"therapy":[135],"(normal":[136],"saline":[137],"or":[138],"dopamine)":[139],"treatment":[141],"hypotension.":[143],"Therefore,":[144],"escalation":[146],"discontinued":[148],"microgram/kg":[152],"level.":[154],"The":[155],"number":[156],"days":[158,199,219],"achieve":[161],"an":[162],"absolute":[163],"neutrophil":[164],"count":[165],"greater":[166],"than":[167,178],"500":[168],"mL":[169],"who":[172,235],"received":[173,236],"less":[177],"(25":[182],"v":[183,207,248],"34;":[184],"P":[185,209,250],"=":[186,210,251],".02).":[187],"This":[188],"appeared":[189],"correlate":[191],"reduced":[194],"incidence":[195],"infection":[197],"between":[198,226],"0":[200],"28":[202],"(12%":[206],"23%;":[208],".049).":[211],"Median":[212],"bilirubin,":[213],"median":[214],"creatinine,":[215],"platelet":[216],"recovery,":[217],"hospital":[222],"different":[225],"study":[227],"controls.":[231],"Survival":[232],"improved":[246],"(30%":[247],"20%;":[249],".04).":[252],"These":[253],"possible":[254],"benefits":[255],"achieved":[257],"cost":[260],"moderate":[262],"during":[264],"administration.":[267]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
