{"id":"https://openalex.org/W2434444698","doi":"https://doi.org/10.1016/j.jad.2016.06.013","title":"Efficacy and tolerability of antidepressants in people aged 65 years or older with major depressive disorder \u2013 A systematic review and a meta-analysis","display_name":"Efficacy and tolerability of antidepressants in people aged 65 years or older with major depressive disorder \u2013 A systematic review and a meta-analysis","publication_year":2016,"publication_date":"2016-06-27","ids":{"openalex":"https://openalex.org/W2434444698","doi":"https://doi.org/10.1016/j.jad.2016.06.013","mag":"2434444698","pmid":"https://pubmed.ncbi.nlm.nih.gov/27389296"},"language":"en","primary_location":{"id":"doi:10.1016/j.jad.2016.06.013","doi":"https://doi.org/10.1016/j.jad.2016.06.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jad.2016.06.013","pdf_url":null,"source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111590561","display_name":"Anne Tham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anne Tham","raw_affiliation_strings":["Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ulf Jonsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ulf Jonsson","raw_affiliation_strings":["Department of Clinical Neuroscience, Division of Insurance Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Neuroscience, Child and Adolescent Psychiatry, Uppsala University, Uppsala, Sweden","Department of Clinical Neuroscience, Division of Insurance Medicine, Karolinska Institutet, Stockholm, Sweden","Department of Neuroscience, Child and Adolescent Psychiatry, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neuroscience, Division of Insurance Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Neuroscience, Child and Adolescent Psychiatry, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Clinical Neuroscience, Division of Insurance Medicine, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Neuroscience, Child and Adolescent Psychiatry, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080370996","display_name":"Gerhard Andersson","orcid":"https://orcid.org/0000-0003-4753-6745","observed_orcids":["https://orcid.org/0000-0003-4753-6745"]},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gerhard Andersson","raw_affiliation_strings":["Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden; Department of Behavioural Sciences and Learning, Link\u00f6ping University, Link\u00f6ping, Sweden","Department of Behavioural Sciences and Learning, Link\u00f6ping University, Link\u00f6ping, Sweden","Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden; Department of Behavioural Sciences and Learning, Link\u00f6ping University, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I102134673","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Behavioural Sciences and Learning, Link\u00f6ping University, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I102134673"]},{"raw_affiliation_string":"Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091486942","display_name":"Anne S\u00f6derlund","orcid":"https://orcid.org/0000-0002-4537-030X","observed_orcids":["https://orcid.org/0000-0002-4537-030X"]},"institutions":[{"id":"https://openalex.org/I82509713","display_name":"M\u00e4lardalen University","ror":"https://ror.org/033vfbz75","country_code":"SE","type":"education","lineage":["https://openalex.org/I82509713"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anne S\u00f6derlund","raw_affiliation_strings":["School of Health, Care and Social Welfare, Physiotherapy, M\u00e4lardalen University, V\u00e4ster\u00e5s, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health, Care and Social Welfare, Physiotherapy, M\u00e4lardalen University, V\u00e4ster\u00e5s, Sweden","institution_ids":["https://openalex.org/I82509713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059885481","display_name":"Per O. Allard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140862","display_name":"SBU - Swedish Agency for Health Technology Assessment and Assessment of Social Services","ror":"https://ror.org/04507cg26","country_code":"SE","type":"government","lineage":["https://openalex.org/I4210140862"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per Allard","raw_affiliation_strings":["Swedish Agency for Health Technology Assessment and Assessment of Social Services, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish Agency for Health Technology Assessment and Assessment of Social Services, Stockholm, Sweden","institution_ids":["https://openalex.org/I4210140862"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034178776","display_name":"G\u00f6ran Bertilsson","orcid":"https://orcid.org/0000-0002-5660-7376","observed_orcids":["https://orcid.org/0000-0002-5660-7376"]},"institutions":[{"id":"https://openalex.org/I4210140862","display_name":"SBU - Swedish Agency for Health Technology Assessment and Assessment of Social Services","ror":"https://ror.org/04507cg26","country_code":"SE","type":"government","lineage":["https://openalex.org/I4210140862"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"G\u00f6ran Bertilsson","raw_affiliation_strings":["Swedish Agency for Health Technology Assessment and Assessment of Social Services, Stockholm, Sweden. Electronic address: goran.bertilsson@sbu.se","Swedish Agency for Health Technology Assessment and Assessment of Social Services, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish Agency for Health Technology Assessment and Assessment of Social Services, Stockholm, Sweden. Electronic address: goran.bertilsson@sbu.se","institution_ids":["https://openalex.org/I4210140862"]},{"raw_affiliation_string":"Swedish Agency for Health Technology Assessment and Assessment of Social Services, Stockholm, Sweden","institution_ids":["https://openalex.org/I4210140862"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5034178776"],"corresponding_institution_ids":["https://openalex.org/I4210140862"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":1.2008,"has_fulltext":false,"cited_by_count":107,"citation_normalized_percentile":{"value":0.74327628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"205","issue":null,"first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10272","display_name":"Mental Health Treatment and Access","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.9869999885559082},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9390000104904175},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8360000252723694},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.972000002861023},{"id":"https://openalex.org/keywords/duloxetine","display_name":"duloxetine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.6869999766349792},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.8230000138282776},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.9869999885559082},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.7940000295639038},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8289999961853027},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.6230000257492065},{"id":"https://openalex.org/keywords/antidepressant-efficacy","display_name":"antidepressant efficacy","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7281070351600647},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6736056804656982},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6114599108695984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.593701958656311},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.5751630067825317},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5023257732391357},{"id":"https://openalex.org/C2780764818","wikidata":"https://www.wikidata.org/wiki/Q411932","display_name":"Duloxetine","level":3,"score":0.5017764568328857},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.48246198892593384},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4788510799407959},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.4611952304840088},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.460570365190506},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4506920278072357},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4472709596157074},{"id":"https://openalex.org/C67774102","wikidata":"https://www.wikidata.org/wiki/Q614132","display_name":"Number needed to treat","level":4,"score":0.4462677538394928},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.445074200630188},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.3043164014816284},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.17603245377540588},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000068736","descriptor_name":"Duloxetine Hydrochloride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jad.2016.06.013","doi":"https://doi.org/10.1016/j.jad.2016.06.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jad.2016.06.013","pdf_url":null,"source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},{"id":"pmid:27389296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27389296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of affective disorders","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320329629","display_name":"Statens beredning f\u00f6r medicinsk och social utv\u00e4rdering","ror":"https://ror.org/04507cg26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W30913657","https://openalex.org/W45877667","https://openalex.org/W88904282","https://openalex.org/W89478080","https://openalex.org/W1780931260","https://openalex.org/W1846868862","https://openalex.org/W1847168837","https://openalex.org/W1968671450","https://openalex.org/W1975934950","https://openalex.org/W1978945985","https://openalex.org/W1980085328","https://openalex.org/W1984937478","https://openalex.org/W1997904161","https://openalex.org/W2011606125","https://openalex.org/W2018273325","https://openalex.org/W2024719656","https://openalex.org/W2029846038","https://openalex.org/W2032653328","https://openalex.org/W2038726638","https://openalex.org/W2043842622","https://openalex.org/W2044170764","https://openalex.org/W2045543396","https://openalex.org/W2045775503","https://openalex.org/W2046955370","https://openalex.org/W2050486061","https://openalex.org/W2052945117","https://openalex.org/W2055080279","https://openalex.org/W2060854717","https://openalex.org/W2064397126","https://openalex.org/W2075544268","https://openalex.org/W2080229560","https://openalex.org/W2095139550","https://openalex.org/W2104981347","https://openalex.org/W2108094099","https://openalex.org/W2116153150","https://openalex.org/W2116650057","https://openalex.org/W2118984041","https://openalex.org/W2121671360","https://openalex.org/W2131823335","https://openalex.org/W2133710857","https://openalex.org/W2135400982","https://openalex.org/W2135425762","https://openalex.org/W2137785805","https://openalex.org/W2140022797","https://openalex.org/W2140451359","https://openalex.org/W2142277854","https://openalex.org/W2143962486","https://openalex.org/W2158176267","https://openalex.org/W2161046810","https://openalex.org/W2162907604","https://openalex.org/W2169860550","https://openalex.org/W2171199381","https://openalex.org/W2213667338","https://openalex.org/W2267903572","https://openalex.org/W3022868799"],"related_works":["https://openalex.org/W2095837197","https://openalex.org/W1983976091","https://openalex.org/W3010844243","https://openalex.org/W4383955261","https://openalex.org/W2962714707","https://openalex.org/W2018273325","https://openalex.org/W2022284750","https://openalex.org/W2164933332","https://openalex.org/W4255074203","https://openalex.org/W2155185302"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}