{"id":"https://openalex.org/W2434354","doi":null,"title":"Sodium chloride treatment of amphotericin B nephrotoxicity. Standard of care?","display_name":"Sodium chloride treatment of amphotericin B nephrotoxicity. Standard of care?","publication_year":1995,"publication_date":"1995-04-01","ids":{"openalex":"https://openalex.org/W2434354","mag":"2434354","pmid":"https://pubmed.ncbi.nlm.nih.gov/7747495","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1022766"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1022766","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1022766","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1022766/pdf/westjmed00056-0021.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West J Med","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1022766/pdf/westjmed00056-0021.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026896650","display_name":"Cheryl Anderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"C M Anderson","raw_affiliation_strings":["Department of Medicine, University of Colorado Health Sciences Center, Denver, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Colorado Health Sciences Center, Denver, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5026896650"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6165,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.67482576,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"162","issue":"4","first_page":"313","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amphotericin-b","display_name":"amphotericin B","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sodium-chloride","display_name":"sodium chloride","score":0.859000027179718},{"id":"https://openalex.org/keywords/salt-loading","display_name":"salt loading","score":0.8339999914169312},{"id":"https://openalex.org/keywords/azotemia","display_name":"azotemia","score":0.8709999918937683},{"id":"https://openalex.org/keywords/antifungal-therapy","display_name":"antifungal therapy","score":0.6600000262260437},{"id":"https://openalex.org/keywords/fungal-infection","display_name":"fungal infection","score":0.7139999866485596},{"id":"https://openalex.org/keywords/immunocompromised-patients","display_name":"immunocompromised patients","score":0.984000027179718},{"id":"https://openalex.org/keywords/drug-induced-nephrotoxicity","display_name":"drug-induced nephrotoxicity","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.8934410810470581},{"id":"https://openalex.org/C2775919214","wikidata":"https://www.wikidata.org/wiki/Q794072","display_name":"Azotemia","level":3,"score":0.8720277547836304},{"id":"https://openalex.org/C2779629538","wikidata":"https://www.wikidata.org/wiki/Q412223","display_name":"Amphotericin B","level":3,"score":0.7829623222351074},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7141016721725464},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5181735754013062},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5135093331336975},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4501323103904724},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.42949947714805603},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.414615273475647},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29617971181869507},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.17009055614471436},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.10350197553634644},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07906478643417358},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000666","descriptor_name":"Amphotericin B","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000666","descriptor_name":"Amphotericin B","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017673","descriptor_name":"Sodium Chloride, Dietary","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1022766","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1022766","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1022766/pdf/westjmed00056-0021.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West J Med","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:85054","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1022766","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:7747495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7747495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Western journal of medicine","raw_type":"Journal Article"},{"id":"mag:2434354","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7747495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1022766","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1022766","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1022766/pdf/westjmed00056-0021.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West J Med","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2434354.pdf","grobid_xml":"https://content.openalex.org/works/W2434354.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1980979859","https://openalex.org/W1982780587","https://openalex.org/W1983809660","https://openalex.org/W1999749195","https://openalex.org/W2004835621","https://openalex.org/W2011370230","https://openalex.org/W2012667050","https://openalex.org/W2018864311","https://openalex.org/W2029529084","https://openalex.org/W2034782717","https://openalex.org/W2073125357","https://openalex.org/W2085511734","https://openalex.org/W2114605201","https://openalex.org/W2118969464","https://openalex.org/W2122283727","https://openalex.org/W2124457491","https://openalex.org/W2186148535","https://openalex.org/W2338433005","https://openalex.org/W2412184241"],"related_works":["https://openalex.org/W2073125357","https://openalex.org/W2101346639","https://openalex.org/W7217893645","https://openalex.org/W2530245528","https://openalex.org/W1983809660","https://openalex.org/W4240428166","https://openalex.org/W1985859405","https://openalex.org/W1974741264","https://openalex.org/W2077912547","https://openalex.org/W2029529084"],"abstract_inverted_index":{"Amphotericin":[0],"B":[1,134],"is":[2,16,47,136],"an":[3,60],"effective":[4],"therapeutic":[5],"agent":[6],"for":[7,77,110],"most":[8],"systemic":[9],"or":[10,127,131],"invasive":[11],"mycoses,":[12],"but":[13,82],"its":[14],"usefulness":[15],"limited":[17,100],"by":[18,44,59],"the":[19,25,38,41,75,106,143],"frequent":[20],"occurrence":[21],"of":[22,30,40,90,122,142],"nephrotoxicity.":[23],"Given":[24],"high":[26],"and":[27,53,92,99,146],"increasing":[28],"frequency":[29],"serious":[31],"fungal":[32],"infections,":[33],"especially":[34],"in":[35,68],"immunocompromised":[36],"patients,":[37],"importance":[39],"morbidity":[42],"caused":[43],"this":[45,78,112],"toxicity":[46],"substantial.":[48],"Salt":[49],"loading":[50],"may":[51,104],"prevent":[52,140],"even":[54],"reverse":[55],"amphotericin":[56,133],"B-induced":[57],"azotemia":[58],"unknown":[61],"mechanism.":[62],"A":[63],"prospective,":[64],"randomized,":[65],"placebo-controlled":[66],"trial":[67],"a":[69,96],"relevant":[70],"patient":[71],"group":[72],"would":[73],"strengthen":[74],"support":[76],"simple,":[79],"safe":[80],"therapy,":[81],"will":[83,138],"not":[84],"likely":[85,139],"be":[86,105,148],"carried":[87,149],"out":[88,150],"because":[89],"practical":[91],"ethical":[93],"considerations.":[94],"Thus,":[95],"few":[97],"prospective":[98],"controlled":[101],"human":[102],"studies":[103],"only":[107],"supportive":[108],"evidence":[109],"using":[111],"therapy.":[113],"Supplementing":[114],"dietary":[115],"sodium":[116,123],"chloride":[117,124],"intake":[118],"with":[119],"150":[120],"mEq":[121],"daily":[125],"intravenously":[126],"orally":[128],"beginning":[129],"when":[130],"before":[132],"therapy":[135],"initiated":[137],"much":[141],"observed":[144],"nephrotoxicity":[145],"should":[147],"routinely.":[151]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
