{"id":"https://openalex.org/W2434126366","doi":null,"title":"[Correlation of plasma thioredoxin reductase activity to growth of H22 hepatocellular carcinoma xenografts in Kunming mice].","display_name":"[Correlation of plasma thioredoxin reductase activity to growth of H22 hepatocellular carcinoma xenografts in Kunming mice].","publication_year":2009,"publication_date":"2009-05-01","ids":{"openalex":"https://openalex.org/W2434126366","mag":"2434126366","pmid":"https://pubmed.ncbi.nlm.nih.gov/19624873"},"language":"zh","primary_location":{"id":"pmid:19624873","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19624873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ai zheng = Aizheng = Chinese journal of cancer","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101980120","display_name":"Qiang Tan","orcid":"https://orcid.org/0000-0002-3978-7184","observed_orcids":["https://orcid.org/0000-0002-3978-7184"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Tan","raw_affiliation_strings":["Department of Chemo-biology, School of Pharmaceutical Sciences, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemo-biology, School of Pharmaceutical Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020186511","display_name":"Xiaoyuan Ren","orcid":"https://orcid.org/0000-0001-5644-9008","observed_orcids":["https://orcid.org/0000-0001-5644-9008"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Yuan Ren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336933","display_name":"Jing Li","orcid":"https://orcid.org/0000-0002-4289-4829","observed_orcids":["https://orcid.org/0000-0002-4289-4829"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100321414","display_name":"Fang Wang","orcid":"https://orcid.org/0000-0002-4781-8673","observed_orcids":["https://orcid.org/0000-0002-4781-8673","https://orcid.org/0000-0003-0404-3190"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fang Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050019014","display_name":"Sheng-ju Deng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sheng-Ju Deng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Hui-Hui Zeng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui-Hui Zeng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"28","issue":"5","first_page":"472","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thioredoxin-reductase","display_name":"thioredoxin reductase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/plasma-enzyme-activity","display_name":"plasma enzyme activity","score":0.8709999918937683},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/h22-cells","display_name":"H22 cells","score":0.7760000228881836},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.9229999780654907},{"id":"https://openalex.org/keywords/thioredoxin-reductase-inhibitors","display_name":"thioredoxin reductase inhibitors","score":0.7760000228881836},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7350000143051147},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C2777737464","wikidata":"https://www.wikidata.org/wiki/Q2540636","display_name":"Thioredoxin reductase","level":4,"score":0.7562738656997681},{"id":"https://openalex.org/C2777426643","wikidata":"https://www.wikidata.org/wiki/Q17915090","display_name":"DTNB","level":4,"score":0.6459393501281738},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6212261319160461},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5759674310684204},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44767674803733826},{"id":"https://openalex.org/C3623737","wikidata":"https://www.wikidata.org/wiki/Q421219","display_name":"Thioredoxin","level":3,"score":0.44518184661865234},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42868250608444214},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3540375828742981},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.34108293056488037},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26979729533195496},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16672149300575256},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.09964972734451294}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013880","descriptor_name":"Thioredoxin-Disulfide Reductase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013880","descriptor_name":"Thioredoxin-Disulfide Reductase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013880","descriptor_name":"Thioredoxin-Disulfide Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016566","descriptor_name":"Organoselenium Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016566","descriptor_name":"Organoselenium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:19624873","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19624873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ai zheng = Aizheng = Chinese journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2510755418","https://openalex.org/W1982782842","https://openalex.org/W2090244729","https://openalex.org/W6987719148","https://openalex.org/W1598696312","https://openalex.org/W7095800903","https://openalex.org/W2905580912","https://openalex.org/W1809663099","https://openalex.org/W2018170676","https://openalex.org/W2102515070"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"OBJECTIVE:":[2],"The":[3,71,95,148],"expression":[4],"and":[5,88,100,124,129,137,167,182,205,209,217,225],"activity":[6,27,45,134,176,202,235,246],"of":[7,24,42,49,131,151,195,200],"thioredoxin":[8],"reductase":[9],"(TrxR)":[10],"are":[11],"significantly":[12],"higher":[13],"in":[14,18,56,97,135,156,162,169,179,189,203,211,219,227],"tumor":[15,29,115,119,138,152,187,206,240,249],"tissues":[16,139],"than":[17],"normal":[19],"tissues,":[20],"but":[21],"the":[22,40,47,193,197],"correlation":[23,41],"plasma":[25,43,136,204],"TrxR":[26,44,133,175,201,234,245],"to":[28,38,46,67,186,239,248],"growth":[30,48,153,250],"has":[31],"seldom":[32],"been":[33],"reported.":[34],"This":[35],"study":[36],"was":[37,140,177,183],"evaluate":[39],"hepatocellular":[50],"carcinoma":[51],"(HCC)":[52],"H22":[53,59],"cell":[54,116],"xenografts":[55],"mice.":[57,191],"METHODS:":[58],"cells":[60],"were":[61,73,103,112,154,207],"injected":[62],"subcutaneously":[63],"into":[64,75],"Kunming":[65],"mice":[66,72,78,96],"establish":[68],"HCC":[69],"model.":[70],"divided":[74],"control":[76,98,180],"group,":[77,79,160,166,215,223],"low":[80,157,212],"dose":[81,85,90,158,164,171,213,221,229],"(36":[82],"mg/kg),":[83],"moderate":[84,163,220],"(72":[86],"mg/kg)":[87,92],"high":[89,170,228],"(216":[91],"ethaselen":[93,159,165,172,214,222,230],"groups.":[94],"group":[99,102],"model":[101],"given":[104],"0.5%":[105],"sodium":[106],"carboxymethyl":[107],"cellulose":[108],"(CMC-Na).":[109],"Blood":[110],"samples":[111],"drawn":[113],"before":[114],"inoculation,":[117],"when":[118],"volume":[120,188],"reached":[121],"100":[122],"mm3,":[123],"at":[125],"Days":[126],"1,":[127],"4":[128],"10":[130],"treatment.":[132],"detected":[141],"by":[142],"dithio-bis-nitrobenzoic":[143],"acid":[144],"(DTNB)":[145],"method.":[146],"RESULTS:":[147],"inhibition":[149,198],"rates":[150,199],"59.5%":[155],"74.3%":[161],"74.9%":[168],"group.":[173,231],"Plasma":[174,233],"stable":[178],"mice,":[181],"correlated":[184,237],"positively":[185,238],"tumor-bearing":[190],"At":[192],"end":[194],"treatment,":[196],"59.2%":[208],"15.3%":[210],"68.4%":[216],"25.8%":[218],"68.9%":[224],"29.8%":[226],"CONCLUSIONS:":[232],"is":[236],"growth.":[241],"Ethaselen":[242],"can":[243],"inhibit":[244],"corresponding":[247],"inhibition.":[251]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}