{"id":"https://openalex.org/W2433623402","doi":null,"title":"Homozygous beta-thalassaemia: a review of patients who had splenectomy at the Royal Alexandra Hospital for Children, Sydney.","display_name":"Homozygous beta-thalassaemia: a review of patients who had splenectomy at the Royal Alexandra Hospital for Children, Sydney.","publication_year":1994,"publication_date":"1994-02-01","ids":{"openalex":"https://openalex.org/W2433623402","mag":"2433623402","pmid":"https://pubmed.ncbi.nlm.nih.gov/8009282"},"language":"en","primary_location":{"id":"pmid:8009282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8009282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Singapore medical journal","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075179010","display_name":"Hoe Ts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802384191","display_name":"Children's Hospital at Westmead","ror":"https://ror.org/05k0s5494","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802384191"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"T S Hoe","raw_affiliation_strings":["Royal Alexandra Hospital for Children, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Alexandra Hospital for Children, Sydney, Australia","institution_ids":["https://openalex.org/I2802384191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111775071","display_name":"A. T. Lammi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Lammi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"B Webster","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Webster","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.32593278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"35","issue":"1","first_page":"59","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homozygous-beta-thalassaemia","display_name":"homozygous beta-thalassaemia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/splenectomy","display_name":"splenectomy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transfusion-requirements","display_name":"transfusion requirements","score":0.7739999890327454},{"id":"https://openalex.org/keywords/deferoxamine","display_name":"deferoxamine","score":0.8410000205039978},{"id":"https://openalex.org/keywords/yersiniosis","display_name":"yersiniosis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/appendicitis","display_name":"appendicitis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/pneumococcal-sepsis","display_name":"pneumococcal sepsis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hemoglobin-levels","display_name":"hemoglobin levels","score":0.6620000004768372},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9720182418823242},{"id":"https://openalex.org/C2776309230","wikidata":"https://www.wikidata.org/wiki/Q580383","display_name":"Splenectomy","level":3,"score":0.93544602394104},{"id":"https://openalex.org/C2776234502","wikidata":"https://www.wikidata.org/wiki/Q135177","display_name":"Yersinia enterocolitica","level":3,"score":0.8540576100349426},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6327159404754639},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5803936123847961},{"id":"https://openalex.org/C2777789151","wikidata":"https://www.wikidata.org/wiki/Q2600216","display_name":"Yersiniosis","level":5,"score":0.5571698546409607},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.555336058139801},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4531635344028473},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45267271995544434},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.14699870347976685},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013156","descriptor_name":"Splenectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8009282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8009282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Singapore medical journal","raw_type":"Comparative Study"},{"id":"mag:2433623402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8009282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2010704507","https://openalex.org/W2043821528","https://openalex.org/W2437733","https://openalex.org/W141926537","https://openalex.org/W2992100606","https://openalex.org/W1976517574","https://openalex.org/W2076736870","https://openalex.org/W2443832808","https://openalex.org/W2604618635","https://openalex.org/W2438132134"],"abstract_inverted_index":{"Twenty-four":[0],"patients":[1,90,118],"with":[2,105],"homozygous":[3],"beta-thalassaemia":[4],"who":[5,24,56,91],"had":[6,25,64,119,132],"been":[7],"splenectomised":[8],"and":[9,67,97,107,128,142,149],"currently":[10],"on":[11,58,93],"treatment":[12],"were":[13,17,57,92],"studied":[14],"retrospectively.":[15],"They":[16,103],"divided":[18],"into":[19],"two":[20],"groups.":[21],"Group":[22,54],"A:":[23],"splenectomy":[26,50,66,85],"prior":[27],"to":[28,46,77],"commencement":[29],"of":[30,80,109,116,159],"any":[31],"regular":[32,59,94],"blood":[33,60,70,95],"transfusion.":[34],"The":[35],"mean":[36,69],"haemoglobin":[37],"for":[38],"this":[39],"group":[40],"rose":[41],"from":[42,74],"5.5":[43],"gm/dl":[44,48],"pre-splenectomy":[45],"7.7":[47],"post":[49],"(p":[51,86],"<":[52,87],"0.001).":[53,88],"B:":[55],"transfusion":[61,71,96],"when":[62],"they":[63],"their":[65],"the":[68,117],"requirement":[72],"dropped":[73],"317":[75],"ml/kg/yr":[76,79],"230":[78],"packed":[81],"red":[82],"cells":[83],"following":[84],"Three":[89],"desferrioxamine":[98,144],"developed":[99],"Yersinia":[100,126,134],"enterocolitica":[101,127,135],"infection.":[102],"presented":[104],"fever":[106,141],"signs":[108],"an":[110],"acute":[111,120],"abdomen.":[112],"At":[113],"laparotomy,":[114],"2":[115],"appendicitis.":[121],"All":[122],"3":[123],"appendices":[124],"grew":[125],"one":[129],"patient":[130,139],"also":[131],"a":[133,138],"septicaemia.":[136],"If":[137],"develops":[140],"enteritis,":[143],"should":[145],"be":[146],"stopped":[147],"temporarily":[148],"cotrimoxazole":[150],"started":[151],"as":[152],"prophylaxis":[153],"against":[154],"systemic":[155],"Yersiniosis.":[156],"No":[157],"cases":[158],"pneumoccocal":[160],"sepsis":[161],"was":[162],"reported.":[163]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}