{"id":"https://openalex.org/W2433524883","doi":null,"title":"affective disorder Neurocognitive impairment in euthymic patients with bipolar","display_name":"affective disorder Neurocognitive impairment in euthymic patients with bipolar","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2433524883","mag":"2433524883"},"language":"en","primary_location":{"id":"mag:2433524883","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/John_Gray3/publication/8101121_Neurocognitive_impairment_in_euthymic_patients_with_bipolar_affective_disorder/links/0fcfd505af37e8be6b000000.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058414502","display_name":"Allan Hunter Young","orcid":"https://orcid.org/0000-0003-2291-6952","observed_orcids":["https://orcid.org/0000-0003-2291-6952","https://orcid.org/0000-0002-4130-5914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allan H. Young","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2291-6952","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104109930","display_name":"Jill Maria Thompson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jill M. Thompson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085882519","display_name":"Peter Gallagher","orcid":"https://orcid.org/0000-0002-9808-7460","observed_orcids":["https://orcid.org/0000-0002-9808-7460"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Gallagher","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9808-7460","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101735323","display_name":"John H. Hughes","orcid":"https://orcid.org/0000-0003-3753-3284","observed_orcids":["https://orcid.org/0000-0003-3753-3284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Hughes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3753-3284","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087798145","display_name":"Stuart Watson","orcid":"https://orcid.org/0000-0002-2558-3367","observed_orcids":["https://orcid.org/0000-0002-2558-3367"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stuart Watson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2558-3367","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109530783","display_name":"John M Gray","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Gray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047610109","display_name":"Ian Nicol Ferrier","orcid":"https://orcid.org/0000-0002-1800-1648","observed_orcids":["https://orcid.org/0000-0002-1800-1648"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Nicol Ferrier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neurocognitive-impairment","display_name":"neurocognitive impairment","score":0.8939999938011169},{"id":"https://openalex.org/keywords/euthymia","display_name":"euthymia","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hypercortisolism","display_name":"hypercortisolism","score":0.9599999785423279},{"id":"https://openalex.org/keywords/salivary-cortisol","display_name":"salivary cortisol","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.46799999475479126},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.7600454092025757},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.6629036664962769},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6080348491668701},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.4287177622318268},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.42037463188171387},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.4024852216243744},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.35064804553985596},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3183361291885376},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.09994041919708252}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2433524883","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/John_Gray3/publication/8101121_Neurocognitive_impairment_in_euthymic_patients_with_bipolar_affective_disorder/links/0fcfd505af37e8be6b000000.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W589271961","https://openalex.org/W1562811233","https://openalex.org/W1965143003","https://openalex.org/W1968080961","https://openalex.org/W1976171769","https://openalex.org/W1982063639","https://openalex.org/W1987494895","https://openalex.org/W1991529539","https://openalex.org/W2002664886","https://openalex.org/W2004649797","https://openalex.org/W2008916517","https://openalex.org/W2009485462","https://openalex.org/W2014491795","https://openalex.org/W2023731405","https://openalex.org/W2030141243","https://openalex.org/W2032139509","https://openalex.org/W2035286146","https://openalex.org/W2049081095","https://openalex.org/W2067495470","https://openalex.org/W2085067988","https://openalex.org/W2099987852","https://openalex.org/W2114613490","https://openalex.org/W2128567888","https://openalex.org/W2149470049","https://openalex.org/W2160467320","https://openalex.org/W2167659819","https://openalex.org/W2169848110","https://openalex.org/W2529289625"],"related_works":["https://openalex.org/W2086340288","https://openalex.org/W7026168064","https://openalex.org/W2464011729","https://openalex.org/W4206804001","https://openalex.org/W2988599661","https://openalex.org/W2912396566","https://openalex.org/W1971141494","https://openalex.org/W2604650322","https://openalex.org/W1987494895","https://openalex.org/W2007175563"],"abstract_inverted_index":{"Background":[0],"Persistentimpairmentsinneurocognitivefunctionhavebeendescribedinpatientswithbipolardisorderwhosediseaseisinremission.However,methodologicalissuessuchastheeffectofresidualmoodsymptomsandhypercortisolaemiamayconfoundsuchstudies.Aims":[1],"Toassessneurocognitivefunctioninginprospectively":[2],"verifiedeuthymicpatientswithbipolardisorder.MMetethodhod":[3],"Sixty-threepatientswithbipolardisorderandamatchedcontrolgroupcompletedacomprehensiveneurocognitivetestbattery.Euthymiawasconfirmedinthepatientgroupbyprospectiveclinicalratingsover1monthpriortotesting.Salivasampleswerecollectedtoprofilebasalcortisolsecretion.RReesusulltsts":[4],"Patientswere":[5],"significantlyimpairedacrossabroadrangeofcognitivedomains.Acrossthedomainstested,clinicallysignificantimpairmentwasobservedin3%to42%ofpatients.Deficitswerenotcausallyassociatedwithresidualmoodsymptomsorhypercortisolaemia.Conclusions":[6],"Neurocognitiveimpairmentpersistsinpatientswhosebipolardisorderisinremission.Thismayrepresentatraitabnormalityandbeamarkerofunderlyingneurobiologicaldysfunction.Declarationof":[7],"interest":[8],"None.FundingdetailedinAcknowledgements.":[9]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}