{"id":"https://openalex.org/W2433435151","doi":null,"title":"[Expression of programmed cell death 4 and its clinicopathological significance in human pancreatic cancer].","display_name":"[Expression of programmed cell death 4 and its clinicopathological significance in human pancreatic cancer].","publication_year":2005,"publication_date":"2005-10-01","ids":{"openalex":"https://openalex.org/W2433435151","mag":"2433435151","pmid":"https://pubmed.ncbi.nlm.nih.gov/16274040"},"language":"zh","primary_location":{"id":"pmid:16274040","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16274040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101606946","display_name":"Gang Ma","orcid":"https://orcid.org/0009-0005-4045-5266","observed_orcids":["https://orcid.org/0009-0005-4045-5266"]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Ma","raw_affiliation_strings":["Department of General Surgery, the First Affiliated Hospital,China Medical University, Shenyang 110001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, the First Affiliated Hospital,China Medical University, Shenyang 110001, China","institution_ids":["https://openalex.org/I4210140515","https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102360985","display_name":"Kejian Guo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ke-jian Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100396860","display_name":"Hao Zhang","orcid":"https://orcid.org/0000-0002-1437-9918","observed_orcids":["https://orcid.org/0000-0002-1437-9918"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hao Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026097438","display_name":"Iwata Ozaki","orcid":"https://orcid.org/0000-0001-8542-1434","observed_orcids":["https://orcid.org/0000-0001-8542-1434"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iwata Ozaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109153726","display_name":"Sachiko Matsuhashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sachiko Matsuhashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000135673","display_name":"Xinyu Zheng","orcid":"https://orcid.org/0000-0001-8425-3379","observed_orcids":["https://orcid.org/0000-0001-8425-3379","https://orcid.org/0009-0004-0270-5335"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin-Yu Zheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101177063","display_name":"Ming Dong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming Dong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8615,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.75837899,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"27","issue":"5","first_page":"597","last_page":"600"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pdcd4","display_name":"PDCD4","score":0.9290000200271606},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-suppressor-expression","display_name":"tumor suppressor protein expression","score":0.7919999957084656},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/histological-grade","display_name":"histological grade","score":0.9860000014305115},{"id":"https://openalex.org/keywords/clinicopathological-significance","display_name":"clinicopathological significance","score":0.7749999761581421},{"id":"https://openalex.org/keywords/tnm-stage","display_name":"TNM stage","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8107484579086304},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7706347107887268},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.7091426849365234},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.512622058391571},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5063351392745972},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.48446035385131836},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.4655018448829651},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46100208163261414},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.44255369901657104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4350922107696533},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4108361601829529},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3520638942718506},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.23383191227912903},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21267038583755493},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12419360876083374},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16274040","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16274040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae","raw_type":"English Abstract"},{"id":"mag:2433435151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16274040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2386251640","https://openalex.org/W2265410596","https://openalex.org/W300994291","https://openalex.org/W2022754071","https://openalex.org/W2419354712","https://openalex.org/W1536540111","https://openalex.org/W2982403109","https://openalex.org/W2586322479","https://openalex.org/W2187414917","https://openalex.org/W2391246764"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,26,107,118,138,149,171,179,194,252,266],"expression":[4,27,46,81,101,116,119,146,150,188,204,210,225],"of":[5,28,34,47,76,91,99,114,121,144,152,170,178,186,193,202,239,255,270],"programmed":[6],"cell":[7],"death":[8],"4":[9],"(PDCD4)":[10],"protein":[11,30,49,123,154,241],"and":[12,37,97,112,127,132,158,165,175,226,234,248,268],"its":[13],"clinicopathological":[14,228],"significance":[15],"in":[16,31,40,53,62,84,94,103,129,155,244,265],"human":[17,245,256],"pancreatic":[18,35,57,72,86,246,257,271],"cancer.":[19,258],"METHODS:":[20],"Immunohistochemistry":[21],"was":[22,50,82,211,220],"used":[23],"to":[24],"examine":[25],"PDCD4":[29,48,80,122,153,209,224,240,259],"69":[32,85],"specimens":[33],"cancer":[36,58,87,247],"Western":[38,67],"blot":[39],"8":[41,55],"fresh":[42,56],"specimens.":[43],"RESULTS:":[44],"The":[45],"significantly":[51],"lower":[52],"all":[54],"tissues":[59,64,88],"than":[60,142],"that":[61,207],"non-cancerous":[63,71],"detected":[65],"by":[66],"blot.":[68],"Compared":[69],"with":[70,110,213,251],"tissue":[73],"(>":[74],"80%":[75,113],"positive":[77,92,100,115,145,187,203],"cells),":[78],"low":[79,208,243],"shown":[83],"(<":[89],"30%":[90,111,143,185,201],"cells":[93,102],"36":[95,139],"cases":[96,109,140,161,174,182],"30%-80%":[98],"33":[104,108],"cases).":[105],"In":[106,137],"cells,":[117,147,205],"rates":[120],"were":[124,162],"57.6%,":[125],"24.2%,":[126],"18.2%":[128],"well,":[130,156],"moderately,":[131,157],"poorly":[133,159,180],"differentiated":[134,160,173,181,196],"cancers,":[135],"respectively.":[136,167],"less":[141],"however,":[148,198],"rate":[151],"19.4%,":[163],"41.7%,":[164],"38.9%,":[166],"67.4%":[168],"(15/23)":[169],"moderately":[172],"70%":[176],"(14/20)":[177],"showed":[183,199],"<":[184,200,217],"cells.":[189],"Only":[190],"26.9%":[191],"(7/26)":[192],"well":[195],"cases,":[197],"indicating":[206],"associated":[212],"histological":[214],"grade":[215],"(P":[216],"0.01).":[218],"There":[219],"no":[221],"relationship":[222],"between":[223],"other":[227],"parameters":[229],"including":[230],"patients'":[231],"sex,":[232],"age,":[233],"TNM":[235],"stage.":[236],"CONCLUSIONS:":[237],"Expression":[238],"is":[242,249],"correlated":[250],"differentiation":[253],"levels":[254],"may":[260],"play":[261],"an":[262],"important":[263],"role":[264],"occurrence":[267],"development":[269],"carcinomas.":[272]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}