{"id":"https://openalex.org/W2433337148","doi":null,"title":"[TGF-beta and platelet].","display_name":"[TGF-beta and platelet].","publication_year":1994,"publication_date":"1994-04-01","ids":{"openalex":"https://openalex.org/W2433337148","mag":"2433337148","pmid":"https://pubmed.ncbi.nlm.nih.gov/8028182"},"language":"ja","primary_location":{"id":"pmid:8028182","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8028182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007136213","display_name":"Katsuhisa Kogawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Kogawa","raw_affiliation_strings":["Department of Internal Medicine, Sapporo Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Sapporo Medical University","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059047146","display_name":"Yoshihiro MOGI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Mogi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005041946","display_name":"K Morii","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Morii","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008694549","display_name":"Rishu Takimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Takimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110059755","display_name":"Y Niitsu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Niitsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"4","first_page":"370","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.70169997215271,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.70169997215271,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.23000000417232513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.06210000067949295,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9950000047683716},{"id":"https://openalex.org/keywords/myelofibrosis","display_name":"myelofibrosis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/megakaryocytes","display_name":"megakaryocytes","score":0.9399999976158142},{"id":"https://openalex.org/keywords/megakaryoblasts","display_name":"megakaryoblasts","score":0.9980000257492065},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.8370000123977661},{"id":"https://openalex.org/keywords/latent-tgf-beta","display_name":"latent TGF-beta","score":0.9760000109672546},{"id":"https://openalex.org/keywords/collagen-synthesis","display_name":"collagen synthesis","score":0.6439999938011169},{"id":"https://openalex.org/keywords/megakaryoblastic-leukemia","display_name":"megakaryoblastic leukemia","score":0.7239999771118164},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.8255959153175354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6601135730743408},{"id":"https://openalex.org/C2779705218","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocyte","level":4,"score":0.632826566696167},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5913999676704407},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.5279074311256409},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4685671627521515},{"id":"https://openalex.org/C2778378607","wikidata":"https://www.wikidata.org/wiki/Q4677933","display_name":"Acute megakaryoblastic leukemia","level":3,"score":0.4559997618198395},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4354686737060547},{"id":"https://openalex.org/C111001777","wikidata":"https://www.wikidata.org/wiki/Q3562192","display_name":"TGF beta signaling pathway","level":3,"score":0.4256812334060669},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.38171958923339844},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35641780495643616},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34076473116874695},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3079017996788025},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19595715403556824},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.18945768475532532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1864091157913208},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055728","descriptor_name":"Primary Myelofibrosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D055728","descriptor_name":"Primary Myelofibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8028182","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8028182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","raw_type":"English Abstract"},{"id":"mag:2433337148","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8028182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2069811721","https://openalex.org/W1567871149","https://openalex.org/W651537293","https://openalex.org/W2150656708","https://openalex.org/W2408802501","https://openalex.org/W7134975024","https://openalex.org/W3097564079","https://openalex.org/W2153623293","https://openalex.org/W2008647897","https://openalex.org/W2053620613"],"abstract_inverted_index":{"In":[0,20,63,133],"the":[1,6,16,21,35,39,56,77,156,160,173],"present":[2],"paper,":[3],"we":[4,71],"investigated":[5,34],"pathophysiological":[7],"implication":[8],"of":[9,18,24,27,81,107,162,168,175,205,228],"TGF-beta":[10,36,74,109,112,119,144,164,170,184,207],"from":[11,43,83,125,202],"megakaryocytes":[12,28,42,131,193],"or":[13],"megakaryoblasts":[14,68,82,181],"in":[15,38,76,117],"development":[17],"myelofibrosis.":[19,93],"bone":[22,40],"marrow":[23,41],"myelofibrosis,":[25,189],"proliferation":[26],"is":[29,219],"often":[30],"noticed.":[31],"We":[32],"therefore":[33],"expression":[37],"12":[44],"chronic":[45],"myeloproliferative":[46],"disorder":[47],"patients":[48],"with":[49,86,152,172],"myelofibrosis":[50],"by":[51,105,198],"immunohistochemical":[52],"analysis.":[53],"About":[54],"all":[55],"specimen":[57],"showed":[58,96,159],"strong":[59,97],"positivity":[60],"for":[61,224],"TGF-beta.":[62,196,229],"order":[64],"to":[65,122,127,148,214,221],"examine":[66],"whether":[67],"produce":[69,149,182,194],"TGF-beta,":[70],"then":[72],"measured":[73],"activity":[75,101],"conditioned":[78],"medium":[79],"(CM)":[80],"a":[84,137],"patient":[85],"acute":[87],"megakaryoblastic":[88,138],"leukemia":[89],"who":[90],"had":[91],"profound":[92],"The":[94],"CM":[95],"collagen":[98],"synthesis":[99],"stimulating":[100],"which":[102,141,199,218],"was":[103,120,145,208,212],"nullified":[104],"addition":[106],"anti":[108],"antibody.":[110],"Since":[111],"exists":[113],"as":[114],"latent":[115,128,169,195],"form":[116,129],"platelets,":[118],"considered":[121,220],"be":[123,222],"altered":[124],"active":[126,143,163,183,206],"during":[130],"differentiation.":[132],"this":[134],"context,":[135],"MEG-01,":[136],"cell":[139],"line":[140],"produces":[142],"underwent":[146],"differentiation":[147],"platelet-like":[150],"bleb":[151],"TPA":[153],"treatment.":[154],"During":[155],"differentiation,":[157],"MEG-01":[158,211],"decrease":[161],"production":[165,174],"and":[166,185],"increase":[167],"together":[171],"LTBP.":[176],"These":[177],"results":[178],"suggest":[179],"that":[180],"may":[186,187],"cause":[188],"while":[190],"more":[191],"differentiated":[192],"Mechanism":[197],"megakaryoblast":[200],"escape":[201],"negative":[203],"autocrine":[204],"also":[209],"investigated.":[210],"found":[213],"express":[215],"mutated":[216],"p53":[217],"responsible":[223],"impaired":[225],"signal":[226],"transduction":[227]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}