{"id":"https://openalex.org/W2432916952","doi":"https://doi.org/10.1152/ajpcell.1997.272.1.c41","title":"BAY K 8644 and ClO4- potentiate caffeine contracture without Ca2+ release channel activation","display_name":"BAY K 8644 and ClO4- potentiate caffeine contracture without Ca2+ release channel activation","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2432916952","doi":"https://doi.org/10.1152/ajpcell.1997.272.1.c41","mag":"2432916952","pmid":"https://pubmed.ncbi.nlm.nih.gov/9038809"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.1997.272.1.c41","doi":"https://doi.org/10.1152/ajpcell.1997.272.1.c41","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1997.272.1.c41","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111799738","display_name":"Toshiharu \u00d4ba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Oba","raw_affiliation_strings":["Department of Physiology, Nagoya City University Medical School,Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Nagoya City University Medical School,Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085143964","display_name":"Makoto Koshita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Koshita","raw_affiliation_strings":["Department of Physiology, Nagoya City University Medical School,Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Nagoya City University Medical School,Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Aoki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Aoki","raw_affiliation_strings":["Department of Physiology, Nagoya City University Medical School,Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Nagoya City University Medical School,Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108216201","display_name":"M. Yamaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Yamaguchi","raw_affiliation_strings":["Department of Physiology, Nagoya City University Medical School,Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Nagoya City University Medical School,Japan","institution_ids":["https://openalex.org/I33858575"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I33858575"],"apc_list":null,"apc_paid":null,"fwci":0.3969,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.51630659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"272","issue":"1","first_page":"C41","last_page":"C47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bay-k-8644","display_name":"Bay K 8644","score":0.9269999861717224},{"id":"https://openalex.org/keywords/perchlorate","display_name":"perchlorate","score":0.9079999923706055},{"id":"https://openalex.org/keywords/caffeine-contracture","display_name":"caffeine contracture","score":0.906000018119812},{"id":"https://openalex.org/keywords/calcium-release-channel","display_name":"calcium release channel","score":0.6759999990463257},{"id":"https://openalex.org/keywords/dihydropyridine-receptor","display_name":"dihydropyridine receptor","score":0.906000018119812},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-calcium-release","display_name":"sarcoplasmic reticulum calcium release","score":0.8740000128746033},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.6240000128746033},{"id":"https://openalex.org/keywords/nifedipine","display_name":"nifedipine","score":0.8889999985694885},{"id":"https://openalex.org/keywords/open-probability","display_name":"open probability","score":0.7789999842643738},{"id":"https://openalex.org/keywords/channel-kinetics","display_name":"channel kinetics","score":0.4519999921321869},{"id":"https://openalex.org/keywords/frog-skeletal-muscle","display_name":"frog skeletal muscle","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.762423038482666},{"id":"https://openalex.org/C2779066535","wikidata":"https://www.wikidata.org/wiki/Q39111","display_name":"Nifedipine","level":3,"score":0.7294598817825317},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5575204491615295},{"id":"https://openalex.org/C2776937108","wikidata":"https://www.wikidata.org/wiki/Q1480291","display_name":"Contracture","level":2,"score":0.5369617342948914},{"id":"https://openalex.org/C2781212610","wikidata":"https://www.wikidata.org/wiki/Q39094","display_name":"Dihydropyridine","level":3,"score":0.5242120027542114},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.4440966844558716},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.39000678062438965},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3766327500343323},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36994504928588867},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.23062199354171753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19431030750274658},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18805664777755737},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18533489108085632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17251437902450562},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.11964026093482971},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001498","descriptor_name":"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002120","descriptor_name":"Calcium Channel Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010472","descriptor_name":"Perchlorates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011892","descriptor_name":"Rana catesbeiana","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017670","descriptor_name":"Sodium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpcell.1997.272.1.c41","doi":"https://doi.org/10.1152/ajpcell.1997.272.1.c41","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1997.272.1.c41","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:9038809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9038809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1576929040","https://openalex.org/W1981878894","https://openalex.org/W1986672870","https://openalex.org/W1996236064","https://openalex.org/W2010873798","https://openalex.org/W2014702350","https://openalex.org/W2038844025","https://openalex.org/W2049636818","https://openalex.org/W2052846145","https://openalex.org/W2054237168","https://openalex.org/W2069892277","https://openalex.org/W2074281756"],"related_works":["https://openalex.org/W2051090242","https://openalex.org/W1975188642","https://openalex.org/W2030920510","https://openalex.org/W2054237168","https://openalex.org/W1965854954","https://openalex.org/W2024074344","https://openalex.org/W2119956322","https://openalex.org/W2020593426","https://openalex.org/W2004542421","https://openalex.org/W1981878894"],"abstract_inverted_index":{"Effects":[0],"of":[1,31,104,165],"perchlorate":[2],"(ClO4-)":[3],"and":[4,11,84,98,100,137,153,167],"BAY":[5,65,85,110,168],"K":[6,66,86,111,169],"8644":[7,67,87,112,170],"on":[8,29],"caffeine":[9,40,55,77],"contracture":[10,28,41,56,78],"Ca2+":[12,106,179],"release":[13,107,180],"channel":[14,108,121,140],"current":[15],"were":[16],"studied":[17],"in":[18,54,178],"frog":[19],"skeletal":[20],"muscle.":[21],"Single":[22],"fibers":[23],"produced":[24],"a":[25,142,175],"small":[26],"transient":[27],"addition":[30],"2.2":[32],"mM":[33,38,128,132],"caffeine.":[34,129],"ClO4":[35,133,166],"at":[36,113],"10":[37,48,82],"enhanced":[39],"3.7-fold.":[42],"This":[43],"effect":[44],"was":[45,57],"inhibited":[46],"by":[47,126,146],"microM":[49,64,115],"nifedipine":[50],"pretreatment.":[51],"An":[52],"increase":[53,177],"also":[58],"obtained":[59],"after":[60],"exposure":[61],"to":[62,141,171],"0.1":[63,114],"for":[68],"1":[69],"h.":[70],"At":[71],"20":[72],"mM,":[73],"external":[74],"K+":[75],"potentiated":[76],"2.2-fold.":[79],"ClO4-":[80],"(<":[81],"mM)":[83],"(0.1-1":[88],"microM)":[89],"did":[90,116],"not":[91,117],"affect":[92],"open":[93,99,144,150],"probability":[94],"(Po),":[95],"unitary":[96],"conductance,":[97],"closed":[101,157],"time":[102,151,158],"constants":[103],"the":[105,120,139,148,155,182],"current.":[109],"further":[118,176],"enhance":[119],"that":[122,163],"had":[123],"been":[124],"activated":[125],"2":[127],"However,":[130],"20-30":[131],"increased":[134],"Po":[135],"significantly":[136],"led":[138],"long":[143],"state":[145],"increasing":[147],"slow":[149],"constant":[152],"decreasing":[154],"fast":[156],"constant.":[159],"These":[160],"results":[161],"suggest":[162],"binding":[164],"dihydropyridine":[172],"receptors":[173],"elicits":[174],"from":[181],"sarcoplasmic":[183],"reticulum.":[184]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
