{"id":"https://openalex.org/W2432865784","doi":"https://doi.org/10.1182/blood.v10.6.623.623","title":"New Data on Microdrepanocytic Disease","display_name":"New Data on Microdrepanocytic Disease","publication_year":1955,"publication_date":"1955-06-01","ids":{"openalex":"https://openalex.org/W2432865784","doi":"https://doi.org/10.1182/blood.v10.6.623.623","mag":"2432865784","pmid":"https://pubmed.ncbi.nlm.nih.gov/14378282"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v10.6.623.623","doi":"https://doi.org/10.1182/blood.v10.6.623.623","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v10.6.623.623","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001188814","display_name":"Ezio Silvestroni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. SILVESTRONI","raw_affiliation_strings":["Istituto di Clinica Medica Generale e Terapia Medica (Director, Professor G. Di Guglielmo), University of Rome, Italy, and the Istituto di Genetica (Director, Professor G. Montalenti), University of Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Clinica Medica Generale e Terapia Medica (Director, Professor G. Di Guglielmo), University of Rome, Italy, and the Istituto di Genetica (Director, Professor G. Montalenti), University of Naples, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036843652","display_name":"Ida Bianco","orcid":"https://orcid.org/0000-0002-5452-4702","observed_orcids":["https://orcid.org/0000-0002-5452-4702"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. BIANCO","raw_affiliation_strings":["Istituto di Clinica Medica Generale e Terapia Medica (Director, Professor G. Di Guglielmo), University of Rome, Italy, and the Istituto di Genetica (Director, Professor G. Montalenti), University of Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Clinica Medica Generale e Terapia Medica (Director, Professor G. Di Guglielmo), University of Rome, Italy, and the Istituto di Genetica (Director, Professor G. Montalenti), University of Naples, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.7254,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.83936652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"10","issue":"6","first_page":"623","last_page":"632"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-trait","display_name":"sickle cell trait","score":0.9660000205039978},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.7160000205039978},{"id":"https://openalex.org/keywords/red-blood-cell-morphology","display_name":"erythrocyte morphology","score":0.8029999732971191},{"id":"https://openalex.org/keywords/erythrocyte-fragility","display_name":"erythrocyte fragility","score":0.7720000147819519},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.8989999890327454},{"id":"https://openalex.org/keywords/pregnancy-complications","display_name":"pregnancy complications","score":0.4659999907016754},{"id":"https://openalex.org/keywords/hypochromic-anemia","display_name":"hypochromic anemia","score":0.878000020980835},{"id":"https://openalex.org/keywords/leukocytosis","display_name":"leukocytosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/nucleated-erythrocytes","display_name":"nucleated erythrocytes","score":0.925000011920929},{"id":"https://openalex.org/keywords/genetic-inheritance","display_name":"genetic inheritance","score":0.4020000100135803},{"id":"https://openalex.org/keywords/sicily","display_name":"Sicily","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7787818908691406},{"id":"https://openalex.org/C2778923028","wikidata":"https://www.wikidata.org/wiki/Q974869","display_name":"Leukocytosis","level":2,"score":0.7707227468490601},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5915467143058777},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.5750735402107239},{"id":"https://openalex.org/C2777566322","wikidata":"https://www.wikidata.org/wiki/Q3536635","display_name":"Sickle cell trait","level":3,"score":0.5547302961349487},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.4808029234409332},{"id":"https://openalex.org/C2778997081","wikidata":"https://www.wikidata.org/wiki/Q1208654","display_name":"Diamond\u2013Blackfan anemia","level":5,"score":0.4284200072288513},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.350410521030426},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3334084749221802},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3217906355857849},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28989362716674805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18880248069763184},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11631232500076294},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07926446199417114},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004913","descriptor_name":"Erythrocytes, Abnormal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013789","descriptor_name":"Thalassemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood.v10.6.623.623","doi":"https://doi.org/10.1182/blood.v10.6.623.623","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v10.6.623.623","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:14378282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14378282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W104372943","https://openalex.org/W317916446","https://openalex.org/W1529039692","https://openalex.org/W2104531696"],"related_works":["https://openalex.org/W304831395","https://openalex.org/W1529039692","https://openalex.org/W3090399704","https://openalex.org/W2043593733","https://openalex.org/W7216517890","https://openalex.org/W2047243027","https://openalex.org/W1532924736","https://openalex.org/W2247012093","https://openalex.org/W2082268922","https://openalex.org/W2439653046"],"abstract_inverted_index":{"Abstract":[0],"1.":[1],"Geographic,":[2],"clinical":[3,46,82],"and":[4,24,51,72,131,134,160,191],"genetic":[5],"data":[6,18],"of":[7,11,34,41,48,55,58,66,69,73,111,157,170,185],"35":[8],"new":[9,172],"cases":[10,57,173],"microdrepanocytic":[12,25,59,94,126,183],"disease":[13,26,60,71,127,184],"are":[14,27,99,129,136],"presented.":[15],"2.":[16],"These":[17],"suggest":[19],"that":[20,116],"sickle":[21,120,192],"cell":[22,121,162,193],"trait":[23],"not":[28],"infrequent":[29],"in":[30,61,77,90,119,123,148,154,179],"the":[31,52,64,70,81,91,109,112,149,155,158,171,176,180,186],"eastern":[32],"district":[33],"Sicily,":[35],"perhaps":[36],"with":[37,93,125,182],"some":[38,56],"small":[39],"foci":[40],"sicklemic":[42],"subjects.":[43],"3.":[44],"The":[45],"history":[47],"adult":[49],"patients":[50,92,181],"personal":[53],"examination":[54],"children":[62],"show":[63,175],"existence":[65],"mild":[67],"forms":[68,74],"appearing":[75],"late":[76],"life.":[78],"4.":[79],"From":[80],"viewpoint,":[83],"this":[84],"series":[85],"shows":[86],"several":[87],"interesting":[88],"findings":[89],"disease:":[95],"painful":[96],"osteoarticular":[97],"crises":[98],"inconstantly":[100],"present;":[101],"splenomegaly":[102],"may":[103],"undergo":[104],"a":[105],"spontaneous":[106],"lessening":[107],"during":[108],"course":[110],"disease,":[113],"analogous":[114],"to":[115,164],"which":[117],"occurs":[118],"anemia;":[122],"women":[124],"miscarriages":[128],"frequent":[130],"successful":[132],"pregnancies":[133],"births":[135],"extremely":[137],"rare.":[138],"5.":[139],"Hematologic":[140],"studies":[141,169],"reveal":[142],"hypochromic":[143],"anemia,":[144],"leukocytosis,":[145],"nucleated":[146],"erythrocytes":[147],"circulating":[150],"blood,":[151],"marked":[152],"abnormalities":[153],"morphology":[156],"erythrocytes,":[159],"decreased":[161],"fragility":[163],"hypotonic":[165],"saline.":[166],"6.":[167],"Genetic":[168],"again":[174],"simultaneous":[177],"presence":[178],"genes":[187],"responsible":[188],"for":[189],"microcythemia":[190],"trait.":[194]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}