{"id":"https://openalex.org/W2432007795","doi":null,"title":"Icariin exerts estrogen-like activity in ameliorating EAE via mediating estrogen receptor \u03b2, modulating HPA function and glucocorticoid receptor expression.","display_name":"Icariin exerts estrogen-like activity in ameliorating EAE via mediating estrogen receptor \u03b2, modulating HPA function and glucocorticoid receptor expression.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2432007795","mag":"2432007795","pmid":"https://pubmed.ncbi.nlm.nih.gov/27186315","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4859920"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4859920","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4859920","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4859920","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064951646","display_name":"Zhisheng Wei","orcid":"https://orcid.org/0000-0002-9141-9418","observed_orcids":["https://orcid.org/0000-0002-9141-9418"]},"institutions":[{"id":"https://openalex.org/I4210119024","display_name":"First Affiliated Hospital of Guangdong Pharmaceutical University","ror":"https://ror.org/02gr42472","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhisheng Wei","raw_affiliation_strings":["Department of Neurology, School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, People's Republic of China","institution_ids":["https://openalex.org/I4210119024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101572202","display_name":"Mengxia Wang","orcid":"https://orcid.org/0000-0002-6141-2418","observed_orcids":["https://orcid.org/0000-0002-6141-2418"]},"institutions":[{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengxia Wang","raw_affiliation_strings":["Intensive Care Unit, Guangdong No. 2 Provincial People's Hospital Guangzhou 510317, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Guangdong No. 2 Provincial People's Hospital Guangzhou 510317, People's Republic of China","institution_ids":["https://openalex.org/I4210153930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103117509","display_name":"Ming-Fan Hong","orcid":"https://orcid.org/0000-0002-0808-7337","observed_orcids":["https://orcid.org/0000-0002-0808-7337"]},"institutions":[{"id":"https://openalex.org/I4210119024","display_name":"First Affiliated Hospital of Guangdong Pharmaceutical University","ror":"https://ror.org/02gr42472","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingfan Hong","raw_affiliation_strings":["Department of Neurology, School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, People's Republic of China","institution_ids":["https://openalex.org/I4210119024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076589879","display_name":"Sheng-Peng Diao","orcid":"https://orcid.org/0000-0002-2680-167X","observed_orcids":["https://orcid.org/0000-0002-2680-167X"]},"institutions":[{"id":"https://openalex.org/I4210119024","display_name":"First Affiliated Hospital of Guangdong Pharmaceutical University","ror":"https://ror.org/02gr42472","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengpeng Diao","raw_affiliation_strings":["Department of Neurology, School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, People's Republic of China","institution_ids":["https://openalex.org/I4210119024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115597668","display_name":"Aiqun Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119024","display_name":"First Affiliated Hospital of Guangdong Pharmaceutical University","ror":"https://ror.org/02gr42472","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aiqun Liu","raw_affiliation_strings":["Department of Neurology, School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, People's Republic of China","institution_ids":["https://openalex.org/I4210119024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068637241","display_name":"Yeqing Huang","orcid":"https://orcid.org/0000-0003-1858-1299","observed_orcids":["https://orcid.org/0000-0003-1858-1299"]},"institutions":[{"id":"https://openalex.org/I4210119024","display_name":"First Affiliated Hospital of Guangdong Pharmaceutical University","ror":"https://ror.org/02gr42472","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yeqing Huang","raw_affiliation_strings":["Department of Neurology, School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, People's Republic of China","institution_ids":["https://openalex.org/I4210119024"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qingyun Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119024","display_name":"First Affiliated Hospital of Guangdong Pharmaceutical University","ror":"https://ror.org/02gr42472","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingyun Yu","raw_affiliation_strings":["Department of Neurology, School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, People's Republic of China","institution_ids":["https://openalex.org/I4210119024"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038685099","display_name":"Zhongxing Peng","orcid":"https://orcid.org/0000-0002-5773-5599","observed_orcids":["https://orcid.org/0000-0002-5773-5599"]},"institutions":[{"id":"https://openalex.org/I4210119024","display_name":"First Affiliated Hospital of Guangdong Pharmaceutical University","ror":"https://ror.org/02gr42472","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongxing Peng","raw_affiliation_strings":["Department of Neurology, School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, People's Republic of China","institution_ids":["https://openalex.org/I4210119024"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4309,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.86874876,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"4","first_page":"1910","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/icariin","display_name":"icariin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/estrogenic-activity","display_name":"estrogenic activity","score":0.781000018119812},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":0.9869999885559082},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.968999981880188},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.8740000128746033},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.9869999885559082},{"id":"https://openalex.org/keywords/white-matter","display_name":"white matter","score":0.8220000267028809},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8009999990463257},{"id":"https://openalex.org/keywords/epimedium","display_name":"Epimedium","score":0.6700000166893005},{"id":"https://openalex.org/keywords/phytoestrogens","display_name":"phytoestrogens","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.7213733792304993},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.7175372838973999},{"id":"https://openalex.org/C2780685212","wikidata":"https://www.wikidata.org/wiki/Q5985057","display_name":"Icariin","level":3,"score":0.6534221768379211},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.6371306777000427},{"id":"https://openalex.org/C96307122","wikidata":"https://www.wikidata.org/wiki/Q15329133","display_name":"Estrogen receptor beta","level":5,"score":0.5992698669433594},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5801360011100769},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5519789457321167},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5211084485054016},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.45968151092529297},{"id":"https://openalex.org/C2777944059","wikidata":"https://www.wikidata.org/wiki/Q903917","display_name":"Selective estrogen receptor modulator","level":5,"score":0.44138142466545105},{"id":"https://openalex.org/C2781393221","wikidata":"https://www.wikidata.org/wiki/Q157746","display_name":"Epimedium","level":4,"score":0.43740034103393555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41717061400413513},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.39646974205970764},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3837811350822449},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.052234947681427},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4859920","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4859920","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:27186315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27186315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"mag:2432007795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27186315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4859920","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4859920","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1726588509","https://openalex.org/W1959664751","https://openalex.org/W1964160392","https://openalex.org/W1966419386","https://openalex.org/W1976492591","https://openalex.org/W1977291689","https://openalex.org/W1984340410","https://openalex.org/W1991618364","https://openalex.org/W1991708590","https://openalex.org/W1998285380","https://openalex.org/W2002819184","https://openalex.org/W2006228075","https://openalex.org/W2007645945","https://openalex.org/W2024695613","https://openalex.org/W2025546076","https://openalex.org/W2028020028","https://openalex.org/W2028836439","https://openalex.org/W2045072541","https://openalex.org/W2045823841","https://openalex.org/W2046706763","https://openalex.org/W2053684857","https://openalex.org/W2059988496","https://openalex.org/W2069668213","https://openalex.org/W2070265035","https://openalex.org/W2070907292","https://openalex.org/W2072708389","https://openalex.org/W2103569067","https://openalex.org/W2110858029","https://openalex.org/W2113577022","https://openalex.org/W2117098665","https://openalex.org/W2126879040","https://openalex.org/W2129661955","https://openalex.org/W2129681072","https://openalex.org/W2142019981","https://openalex.org/W2151852115","https://openalex.org/W2158157016","https://openalex.org/W2164404979","https://openalex.org/W2165939203","https://openalex.org/W2169022857"],"related_works":["https://openalex.org/W2416692762","https://openalex.org/W2036183383","https://openalex.org/W2054568941","https://openalex.org/W2393514726","https://openalex.org/W2007645945","https://openalex.org/W1502768817","https://openalex.org/W1726588509","https://openalex.org/W2038361314","https://openalex.org/W2382859194","https://openalex.org/W2101955633"],"abstract_inverted_index":{"BACKGROUND:":[0],"Estrogen":[1,156,202],"exerts":[2,228],"neuroprotective":[3,50],"and":[4,9,23,62,78,95,105,131,157,187,217,240],"anti-inflammatory":[5],"effects":[6,22,36,73,161],"in":[7,60,76,133,148,167,198,231,246],"EAE":[8,61,77,85,139,153,233],"multiple":[10],"sclerosis":[11],"(MS),":[12],"but":[13],"its":[14],"clinical":[15,103],"application":[16],"is":[17,54,58,145],"hindered":[18],"due":[19],"to":[20,119],"side":[21,35],"risk":[24],"of":[25,45,74,93,123,138,152,165,184,196,206,244],"tumor.":[26],"Phytoestrogen":[27],"structurally":[28],"or":[29,179,193],"functionally":[30],"mimics":[31],"estrogen":[32,127,192],"with":[33,89,99],"fewer":[34],"than":[37,210,224],"endogenous":[38],"estrogen.":[39,155,225],"Icariin":[40],"(ICA),":[41],"an":[42],"active":[43],"component":[44],"Epimedium":[46],"extracts,":[47],"demonstrates":[48],"estrogen-like":[49,229],"effects.":[51],"However,":[52],"it":[53],"unclear":[55],"whether":[56],"ICA":[57,75,94,97,144,158,176,197,214,227,250],"effective":[59,147],"what":[63],"are":[64],"the":[65,71,80,121,134,170,182,204,242],"underlying":[66],"mechanisms.":[67,82],"OBJECTIVE:":[68],"To":[69],"determine":[70],"therapeutic":[72,255],"explore":[79],"possible":[81],"METHODS:":[83],"C57BL/6":[84],"mice":[86],"were":[87,112,117,173,189],"treated":[88],"Diethylstilbestrol,":[90],"different":[91,194],"dose":[92,143],"mid-dose":[96],"combined":[98],"ICI":[100],"182780.":[101],"The":[102],"scores":[104],"serum":[106,163],"Interleukin-17":[107],"(IL-17),":[108],"Corticosterone":[109],"(CORT)":[110],"concentrations":[111,164],"then":[113],"analyzed.":[114],"Western":[115],"blot":[116],"performed":[118],"investigate":[120],"expressions":[122,183],"glucocorticoid":[124],"receptor":[125,128],"(GR),":[126],"alpha":[129],"(ER\u03b1)":[130],"ER\u03b2":[132,188,221],"cerebral":[135,247],"white":[136,248],"matter":[137],"mice.":[140],"RESULTS:":[141],"High":[142],"equally":[146],"ameliorating":[149,232],"neurological":[150],"signs":[151],"as":[154],"has":[159],"no":[160],"on":[162],"IL-17":[166],"EAE.":[168],"While":[169],"CORT":[171],"levels":[172],"decreased":[174],"by":[175,191],"at":[177,215],"mid":[178,216],"high":[180,218],"doses,":[181],"GR,":[185],"ER\u03b1":[186,207],"up-regulated":[190],"doses":[195,219],"a":[199,253],"dosedependent":[200],"manner.":[201],"induced":[203],"elevation":[205],"more":[208,222],"markedly":[209],"ICA.":[211],"In":[212],"contrast,":[213],"promoted":[220],"significantly":[223],"CONCLUSION:":[226],"activity":[230],"via":[234],"mediating":[235],"ER\u03b2,":[236],"modulating":[237],"HPA":[238],"function":[239],"up-regulating":[241],"expression":[243],"GR":[245],"matter.":[249],"may":[251],"be":[252],"promising":[254],"option":[256],"for":[257],"MS.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}