{"id":"https://openalex.org/W2431979256","doi":null,"title":"Superoxide dismutase and catalase in protection of cardiopulmonary bypass-induced cardiac dysfunction and cellular injury.","display_name":"Superoxide dismutase and catalase in protection of cardiopulmonary bypass-induced cardiac dysfunction and cellular injury.","publication_year":1996,"publication_date":"1996-10-01","ids":{"openalex":"https://openalex.org/W2431979256","mag":"2431979256","pmid":"https://pubmed.ncbi.nlm.nih.gov/9191502"},"language":"en","primary_location":{"id":"pmid:9191502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9191502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Canadian journal of cardiology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043483231","display_name":"Kailash Prasad","orcid":"https://orcid.org/0000-0001-5935-7774","observed_orcids":["https://orcid.org/0000-0001-5935-7774"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"K Prasad","raw_affiliation_strings":["Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon. prasadk@sask.usask.ca","Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon. prasadk@sask.usask.ca","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":null,"display_name":"W P Chan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W P Chan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108589481","display_name":"Baikunth B. Bharadwaj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Bharadwaj","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"12","issue":"10","first_page":"1083","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.03310000151395798,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.9319999814033508},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9810000061988831},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":1.0},{"id":"https://openalex.org/keywords/oxygen-free-radicals","display_name":"oxygen free radicals","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cold-crystalloid-cardioplegia","display_name":"cold crystalloid cardioplegia","score":0.8640000224113464},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocytes","display_name":"polymorphonuclear leukocytes","score":0.8220000267028809},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8169999718666077},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/myocardial-injury","display_name":"myocardial injury","score":0.628000020980835},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6019999980926514},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.6899999976158142},{"id":"https://openalex.org/keywords/diastolic-compliance","display_name":"diastolic compliance","score":0.7689999938011169},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8367645144462585},{"id":"https://openalex.org/C48277249","wikidata":"https://www.wikidata.org/wiki/Q1406926","display_name":"Preload","level":3,"score":0.6938043236732483},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.6544206142425537},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6301960945129395},{"id":"https://openalex.org/C2778881276","wikidata":"https://www.wikidata.org/wiki/Q552304","display_name":"Cardiopulmonary bypass","level":2,"score":0.6107951402664185},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.5932714939117432},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5629153251647949},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5524970293045044},{"id":"https://openalex.org/C31861589","wikidata":"https://www.wikidata.org/wiki/Q618068","display_name":"Cardiac index","level":4,"score":0.45741814374923706},{"id":"https://openalex.org/C26635844","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricular pressure","level":3,"score":0.42869651317596436},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4057258069515228},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3813212513923645},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.3378375172615051},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2374964952468872},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.23302388191223145},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.19736000895500183}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002314","descriptor_name":"Cardioplegic Solutions","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002315","descriptor_name":"Cardiopulmonary Bypass","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003187","descriptor_name":"Compliance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003402","descriptor_name":"Creatine Kinase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9191502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9191502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Canadian journal of cardiology","raw_type":"Journal Article"},{"id":"mag:2431979256","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9191502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2135621033","https://openalex.org/W2066401996","https://openalex.org/W2071247502","https://openalex.org/W2562390938","https://openalex.org/W2408752678","https://openalex.org/W2085595077","https://openalex.org/W2396070378","https://openalex.org/W2047057303","https://openalex.org/W2514607207","https://openalex.org/W2000451115"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cardiac":[1],"dysfunction":[2,33,208],"following":[3,134],"cardiopulmonary":[4],"bypass":[5],"(CPB)":[6],"is":[7],"well":[8],"known.":[9],"Various":[10],"possible":[11],"sources":[12],"for":[13],"increased":[14,38,270],"levels":[15,39,118,238,271],"of":[16,40,48,90,100,132,137,205,239,261,272,280],"oxygen":[17],"free":[18],"radicals":[19],"(OFRs)":[20],"exist":[21],"during":[22],"CPB":[23],"and":[24,53,58,97,105,110,116,169,179,193,195,198,202,210,214,225,228,244,251,264,274,277,283],"OFRs":[25,273],"depress":[26],"cardiac":[27,32,62,72,140,158,176,207,262,293],"function.":[28],"Postpump":[29,173],"(following":[30],"CPB)":[31],"may":[34,287],"be":[35,267,288],"due":[36,268],"to":[37,129,163,269],"OFRs.":[41],"METHODS:":[42],"This":[43],"study":[44],"investigated":[45],"the":[46],"effects":[47],"cold":[49,155],"crystalloid":[50,156],"cardioplegia":[51],"with":[52,184,218],"without":[54],"superoxide":[55,281],"dismutase":[56],"(SOD)":[57],"catalase":[59,170],"(CAT)":[60],"on":[61],"function":[63,263],"(cardiac":[64],"index":[65,70],"[CI],":[66],"left":[67],"ventricular":[68,82],"work":[69],"[LVWI]),":[71],"contractility":[73,178,265],"(+dp/dt,":[74],"+dp/dt/PAW":[75],"[pulmonary":[76],"arterial":[77,120],"wedge":[78],"pressure],":[79],"+dp/dt/LVEDP":[80],"[left":[81],"end-diastolic":[83],"pressure]),":[84],"diastolic":[85,180],"compliance":[86,181],"(-dp/dt),":[87],"OFR-producing":[88],"activity":[89],"polymorphonuclear":[91],"leukocytes":[92],"(PMNL-CL);":[93],"creatine":[94],"kinase":[95],"(CK)":[96],"MB":[98],"isoenzyme":[99],"CK":[101,192,224],"(MBCK),":[102],"malondialdehyde":[103],"(MDA),":[104],"white":[106],"blood":[107,121,189,229],"cells":[108],"(WBC)":[109],"PMNLs":[111,245],"from":[112],"coronary":[113],"sinus":[114],"blood;":[115],"lactate":[117],"in":[119,122,175,186,200,220,248,290],"anesthetized":[123],"dogs":[124,143],"at":[125],"various":[126],"times":[127],"(up":[128],"90":[130,135],"mins)":[131],"reperfusion":[133],"mins":[136],"hypothermic":[138],"ischemic":[139],"arrest.":[141],"The":[142,237],"were":[144,182,246],"divided":[145],"into":[146],"three":[147],"groups:":[148],"group":[149,153,160,164,249,252],"I,":[150],"sham":[151],"bypass;":[152],"II,":[154],"cardioplegic":[157],"arrest;":[159],"III,":[161],"similar":[162,247],"II":[165,250],"but":[166],"received":[167],"SOD":[168,213,276],"treatment.":[171],"RESULTS:":[172],"decreases":[174,199],"function,":[177],"associated":[183,217],"increases":[185],"PMNL-CL":[187,221],"activity,":[188,222,227],"MDA,":[190],"plasma":[191,196,223,240],"MBCK,":[194],"lactate,":[197,241],"WBC":[201,243],"PMNLs.":[203],"Prevention":[204],"postpump":[206,259,292],"(function":[209],"contractility)":[211],"by":[212],"CAT":[215,278],"was":[216],"restoration":[219],"MBCK":[226],"MDA":[230],"towards":[231],"control":[232],"values":[233],"although":[234],"not":[235],"complete.":[236],"total":[242],"III.":[253],"CONCLUSIONS:":[254],"These":[255],"results":[256],"suggest":[257],"that":[258,275],"depression":[260],"could":[266],"scavengers":[279],"anion":[282],"hydrogen":[284],"peroxide":[285],"respectively":[286],"effective":[289],"preventing":[291],"dysfunction.":[294]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}